Nanodrug targeting for myocardial ischemia-reperfusion injury: mechanisms, therapeutic strategies, and challenges in clinical translation.

Myocardial ischemia-reperfusion injury (MIRI) remains a major complication following reperfusion therapy for acute myocardial infarction. It involves complex pathological processes including mitochondrial dysfunction, apoptosis, inflammatory cascades, and oxidative stress. Conventional pharmacological treatments are often limited by poor targeting efficiency and systemic toxicity. In contrast, nanomedicine-based delivery systems offer promising translational potential through precise targeting, microenvironment-responsive release, and multi-target synergistic regulation. This review systematically summarizes recent advances in nanotherapeutic strategies targeting mitochondria, apoptotic pathways, inflammation, and reactive oxygen species (ROS), with a focus on mechanistic insights, clinical relevance, and technical challenges. This review provides a multidimensional perspective for future research and highlights key translational barriers to clinical implementation.

• Publication year

  2025

• Venue

  International journal of pharmaceutics

• Publication date

  2025-09-01

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1016/j.ijpharm.2025.126153PMID 40934996
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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