Latent Cognitive Profiles Predict 1-Year Mental Health, Insomnia, Falls, Daily Functioning, and Pain in US Older Adults: A National Longitudinal Study.

OBJECTIVES Cognitive profiles extend traditional binary classifications by revealing subtle, domain-specific deficits in cognitively intact older adults. This study investigates their predictive value for 1-year outcomes in mental health, insomnia, pain, falls, and daily functioning among older adults without cognitive impairment to improve risk stratification and enable tailored interventions. DESIGN Prospective longitudinal cohort study. SETTING AND PARTICIPANTS 2219 community-dwelling adults aged >65 years, cognitively intact at baseline, drawn from the National Health and Aging Trends Study. METHODS Adjusted logistic regressions linked baseline cognitive profiles-derived via latent profile analysis of 6-domain cognitive performance-to 1-year incident outcomes, excluding individuals with preexisting events. RESULTS Participants were classified into 5 predefined cognitive profiles: profile 1, overall intact; profile 2, isolated moderate orientation impairment; profile 3, mild global impairment with preserved orientation; profile 4, mild global impairment with significant orientation impairment; and profile 5, moderate global impairment). Compared with profile 1, profiles 4 and 5 were associated with higher odds of depressive symptoms [odds ratios (ORs) 2.55-2.69] and insomnia (ORs 2.33-2.48), whereas profiles 3 and 5 showed increased odds of anxiety symptoms (ORs 1.66-2.23). Profile 5 also had an elevated risk of falls (OR 1.98) and multiple falls (OR 4.66) within 1 year. Difficulties in daily tasks were noted in profile 2 (shopping: OR 1.79; banking: OR 2.84) and profile 5 (medication management: OR 2.98; laundry: OR 2.11; banking: OR 3.42). All associations reached statistical significance (P < .05), except for pain outcomes. CONCLUSIONS AND IMPLICATIONS Even among cognitively intact older adults, subtle global cognitive decline predicted higher risk of depressive symptoms, anxiety symptoms, insomnia, falls, and impaired daily functioning. Profiles with orientation deficits were vulnerable to depression, shopping, and banking difficulties, whereas global impairment with preserved orientation was linked to increased anxiety symptoms. Implementing early cognitive screening for cognitively intact older adults and targeting both global decline and orientation deficits may mitigate adverse 1-year outcomes.

• Publication year

  2025

• Venue

  Journal of the American Medical Directors Association

• Publication date

  2025-09-08

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1016/j.jamda.2025.105844PMID 40935350
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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