Exercise training for myocardial ischemia reperfusion injury: Mechanism and clinical practice (Review)

Myocardial ischemia reperfusion injury (MIRI) remains a key and difficult issue in the field of cardiovascular diseases, and its pathogenesis involves multiple aspects. Exercise can effectively improve MIRI, and the mechanisms include reducing oxidative stress and inflammatory responses, regulating mitochondrial function and metabolic abnormalities, and so on. For patients undergoing reperfusion, rehabilitation therapy mainly based on exercise has important clinical significance. The present study expounded on the occurrence of MIRI from the perspective of mechanisms and the improvement effect of exercise on MIRI, elaborates on the main current exercise strategies and existing problems from the aspect of clinical practice, and discusses the possible future development directions.

• Publication year

  2025

• Venue

  International Journal of Molecular Medicine

• Publication date

  2025-09-10

• Fields of study

  Medicine

• Identifiers
  DOI 10.3892/ijmm.2025.5632PMID 40937559PMCID 12440276
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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