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SUPRADES: unlocking the versatility of cyclodextrin-based deep eutectic solvents

Nikita V Pawar,Maheshkumar R Borkar

Published 2025 in Journal of drug targeting (Print)

ABSTRACT

Abstract Green and sustainable technologies have emerged in recent years as a result of increased public awareness of the damaging effects that chemicals have on the environment. To replace ionic liquids (ILs) and traditional organic solvents, deep eutectic solvents (DESs) have been created as environmentally friendly solvents in various fields. In recent years researchers have looked at creating deep eutectic supramolecular polymers (DESPs) by combining DESs with macrocyclic host molecules, such as cyclodextrins (CDs), cucurbiturils and crown ethers. The Supramolecular Deep Eutectic Solvents (SUPRADES), Cyclodextrin-based DES (CycloDES) and Low Melting Mixtures (LMMs) are examples of DESPs. This article provides a comprehensive review on SUPRADES and its applications in various areas like drug solubility enhancement, extraction of different compounds, chiral separation, absorption of volatile organic compounds etc. Compared to traditional DESs and ILs, SUPRADES offer advantages like improved selectivity, tuneability, and biocompatibility. Notably, the review highlights the key differences between traditional DESs/ILs and new SUPRADES, including their increased molecular recognition power and designed host–guest interactions. Through the integration of dispersed results, this review sheds fresh light on how SUPRADES can surpass deficiencies of previous systems and proposes future applications for their practical utilisation.

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