Evaluation of Antioxidant Potential, Anticholinesterase Activity and Element Content of Chlorophyllum rhacodes Species

In this study, antioxidant potential, anticholinesterase activity and elemental contents of Chlorophyllum rhacodes were evaluated. In order to determine the antioxidant capacity, total antioxidant level (TAS), total oxidant level (TOS), oxidative stress index (OSI), DPPH radical scavenging activity and FRAP ferric reducing power analyses were applied. According to the obtained results, TAS value was determined as 3.125±0.060 mmol/L, TOS value as 6.821±0.062 µmol/L, OSI value as 0.218±0.003, DPPH activity as 55.430±1.438 mg TE/g and FRAP value as 72.540±1.461 mg TE/g. These data revealed that C. rhacodes showed a significant level of antioxidant activity. In the evaluation of anticholinesterase activity, inhibitory effects against AChE and BChE enzymes were determined and IC₅₀ values ​​were determined as 94.330±1.536 µg/mL and 128.397±1.556 µg/mL, respectively. These results show that C. rhacodes shows limited inhibitory effect on these enzymes but may have a certain level of anticholinesterase potential. According to the results of elemental analysis, Cd (14.78±1.53), Cr (33.17±1.42), Mn (7.35±0.52), Cu (155.77±2.34), Fe (469.30±15.75), Pb (6.98±0.54), Ni (3.66±0.31) and Zn (76.18±2.25) mg/kg levels were detected in mushroom samples. In particular, it was observed that Cd and Cu levels were above the upper limits specified in the literature. This situation shows that C. rhacodes tends to accumulate some heavy metals and may be highly sensitive to environmental pollution. In conclusion, C. rhacodes species exhibits a biologically remarkable profile with certain antioxidant and anticholinesterase activities and can also be considered as a potential indicator species in the biological monitoring of environmental metal exposure.

• Publication year

  2025

• Venue

  Prospects in Pharmaceutical Sciences

• Publication date

  2025-10-05

• Fields of study

  Not labeled

• Identifiers
  DOI 10.56782/pps.521
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Extract optimization and biological activities of Otidea onotica using Artificial Neural Network-Genetic Algorithm and response surface methodology techniques

  2025cited by this paper
• Optimization of Phellinus hartigii extracts: Biological activities, and phenolic content analysis

  2025cited by this paper
• Bioactivity of the Gray Knight Mushroom Tricholoma terreum (Agaricomycetes): Antioxidant, Antiproliferative, and Enzyme Inhibition Potential.

  2025cited by this paper
• Phytochemical Properties and Bioactive Potential of Various Astragalus spp. from Turkey

  2025cited by this paper
• Single and Multi-Objective Optimization of the Red Pine Mushroom Lactarius deliciosus (Agaricomycetes) Extraction Conditions Using Artificial Intelligence Methods and Biological Activities of Optimized Extracts.

  2025influential reference
• Identification of Phenolic Content, Fatty-Acid Compositions, Antioxidant and Antimicrobial Activity, and Enzyme Inhibition Effects of Endemic Achillea boissieri and Achillea cucullata

  2025cited by this paper
• A hybrid artificial neural network and multi-objective genetic algorithm approach to optimize extraction conditions of Mentha longifolia and biological activities

  2024cited by this paper
• Mitigating Oxidative Stress and Promoting Cellular Longevity with Mushroom Extracts

  2024cited by this paper
• Biological Activities of the Golden Chantarelle Mushroom Cantharellus cibarius (Agaricomycetes) Extracts Obtained as a Result of Single and Multi-Objective Optimization Studies.

  2024influential reference
• Some biological activities and element levels of Lycoperdon pratense

  2024cited by this paper
• Biological Activities of Ethanol Extracts of Hericium erinaceus Obtained as a Result of Optimization Analysis

  2024cited by this paper
• Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites

  2024cited by this paper
• LC‐HRMS Profiling of Phytochemicals with Assessment of Antioxidant, Anticholinesterase, and Antimicrobial Potentials of Astragalus Brachystachys DC

  2024cited by this paper
• Bioactive Secondary Metabolites in Mushrooms: A Focus on Polyphenols, Their Health Benefits and Applications

  2024cited by this paper
• The Anticholinesterase Perspective of Dimethoxyindole Based Benzenesulfonamides: Synthesis, Biological Investigation and Molecular Docking Applications

  2024cited by this paper
• Antimicrobial potential of mushrooms Macrolepiota procera and Chlorophyllum rhacodes

  2023cited by this paper
• ANTIOXIDANT, ANTIMICROBIAL ACTIVITIES, TOTAL PHENOLIC AND ELEMENT CONTENTS OF WILD EDIBLE MUSHROOM BOVISTA NIGRESCENS

  2023influential reference
• Medicinal mushrooms: a comprehensive study on their antiviral potential

  2023cited by this paper
• The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium.

  2023cited by this paper
• Total Antioxidant, Antimicrobial, Antiproliferative Potentials and Element Contents of Wild Mushroom Candolleomyces candolleanus (Agaricomycetes) from Turkey.

  2022cited by this paper
• Wild mushrooms from Ilgaz Mountain National Park (Western Black Sea, Turkey): element concentrations and their health risk assessment

  2022cited by this paper
• Mushrooms as Potential Sources of Active Metabolites and Medicines

  2022cited by this paper
• Application of artificial neural network coupling multi objective‐particle swarm optimization algorithm to optimize Pleurotus ostreatus extraction parameters

  2022cited by this paper
• Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation

  2022cited by this paper
• Mushroom Polysaccharides as Potential Candidates for Alleviating Neurodegenerative Diseases

  2022cited by this paper
• Comment on Got milk? A case series of an amatoxin-exposed family, including a breastfeeding m other and infant

  2021cited by this paper
• Anticancer, antimicrobial, antioxidant and DNA protective potential of mushroom Leucopaxillus gentianeus (Quél.) Kotl.

  2021cited by this paper
• A review of the therapeutic and biological effects of edible and wild mushrooms

  2021cited by this paper
• Occurrence of gilled fungi in Puducherry, India

  2021cited by this paper
• Mycopharmaceuticals and Nutraceuticals: Promising Agents to Improve Human Well-Being and Life Quality

  2021cited by this paper
• Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases.

  2021cited by this paper
• Yabani Yenilebilir Mantar Suillus granulatus'un Antioksidan Potansiyeli ve Element İçerikleri

  2020cited by this paper
• Cadmium and Lead Exposure, Nephrotoxicity, and Mortality

  2020cited by this paper
• Radiocesium (137Cs) and Mineral Elements in Culinary-Medicinal Mushrooms from the Southern Outskirts of Kyiv, Ukraine.

  2019cited by this paper
• Discussion of development processes in insect‐fungus association derived from the shaggy parasol fruiting on the nests of hairy wood ants

  2019cited by this paper
• The Accumulation of Risk and Essential Elements in Edible Mushrooms Chlorophyllum rhacodes, Suillus grevillei, Imleria badia, and Xerocomellus chrysenteron Growing in the Czech Republic

  2019influential reference
• Fomitopsis pinicola in healthful dietary approach and their therapeutic potentials

  2017cited by this paper
• Chemical Compositions and Antioxidant Activities of 16 Wild Edible Mushroom Species Grown in Anatolia

  2012influential reference
• Fatty Acid Analysis of Anaerobic Ruminal Fungi Neocallimastix, Caecomyces and Orpinomyces

  2010cited by this paper
• Evaluation of plant seedling water stress using dynamic fluorescence index with blue LED-based fluorescence imaging

  2010cited by this paper
• A new automated colorimetric method for measuring total oxidant status.

  2005cited by this paper
• A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation.

  2003cited by this paper
• Dietary Supplements from Medicinal Mushrooms: Diversity of Types and Variety of Regulations

  2000cited by this paper
• A new and rapid colorimetric determination of acetylcholinesterase activity.

  1961cited by this paper

• No citing papers are available for this paper.