Progesterone‐Induced Blocking Factor Inhibits Degranulation of Natural Killer Cells

PROBLEM: During the first trimester of pregnancy, nonclassical (CD3—, CD56+, CD16—, perforin [P]bright +) natural killer (NK) cells comprise the major decidual lymphocyte population. These cells, in spite of their high perforin content, exert a low cytolytic activity. Peripheral blood lymphocytes of healthy pregnant women produce progesterone‐induced blocking factor (PIBF), which inhibits NK activity. PIBF‐producing cells are likely to be present in decidua and might contribute to low decidual NK activity.

• Publication year

  1999

• Venue

  American Journal of Reproductive Immunology

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1600-0897.1999.tb00468.xPMID 10476687
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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