Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Cancer Research

• Publication date

  2005-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-04-3714PMID 15994956
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells.

  2004cited by this paper
• Inhibition of type 2 17β-hydroxysteroid dehydrogenase by estradiol derivatives bearing a lactone on the D-ring: structure–activity relationships

  2004influential reference
• 2-Methoxyestradiol: an Endogenous Antiangiogenic and Antiproliferative Drug Candidate

  2004cited by this paper
• Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro.

  2004cited by this paper
• The selective estrogen enzyme modulators in breast cancer: a review.

  2004cited by this paper
• Tissue Inhibitor of Metalloproteinase-1 Protects Human Breast Epithelial Cells Against Intrinsic Apoptotic Cell Death via the Focal Adhesion Kinase/Phosphatidylinositol 3-Kinase and MAPK Signaling Pathway*

  2003cited by this paper
• Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry

  2003cited by this paper
• TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism.

  2003cited by this paper
• Apo2L/TRAIL and its death and decoy receptors

  2003cited by this paper
• TIMP-1 inhibits apoptosis in breast carcinoma cells via a pathway involving pertussis toxin-sensitive G protein and c-Src.

  2003cited by this paper
• Cellular FLICE/Caspase-8–Inhibitory Protein as a Principal Regulator of Cell Death and Survival in Human Hepatocellular Carcinoma

  2003cited by this paper
• Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors

  2003cited by this paper
• Nature's TRAIL--on a path to cancer immunotherapy.

  2003cited by this paper
• Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.

  2003cited by this paper
• Structural and Functional Uncoupling of the Enzymatic and Angiogenic Inhibitory Activities of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2)

  2003cited by this paper
• A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2

  2003cited by this paper
• The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

  2002cited by this paper
• T cells require TRAIL for optimal graft-versus-tumor activity

  2002cited by this paper
• Tissue Inhibitor of Metalloproteinase-3 Induces a Fas-associated Death Domain-dependent Type II Apoptotic Pathway*

  2002cited by this paper
• Increased Susceptibility to Tumor Initiation and Metastasis in TNF-Related Apoptosis-Inducing Ligand-Deficient Mice1

  2002cited by this paper
• Tissue inhibitor of metalloproteinases‐1 attenuates spontaneous liver fibrosis resolution in the transgenic mouse

  2002cited by this paper
• Inhibition of Apoptosis of Activated Hepatic Stellate Cells by Tissue Inhibitor of Metalloproteinase-1 Is Mediated via Effects on Matrix Metalloproteinase Inhibition

  2002cited by this paper
• Enhanced mRNA expression of tissue inhibitor of metalloproteinase‐1 (TIMP‐1) in breast carcinomas is correlated with adverse prognosis

  2002cited by this paper
• Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

  2002cited by this paper
• Stimulation of mammary tumorigenesis by systemic tissue inhibitor of matrix metalloproteinase 4 gene delivery.

  2001cited by this paper
• Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.

  2001cited by this paper
• Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.

  2001cited by this paper
• The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors.

  2001cited by this paper
• Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells

  2001cited by this paper
• The Human Immunodeficiency Virus Type 1 Accessory Protein Vpu Induces Apoptosis by Suppressing the Nuclear Factor κB–dependent Expression of Antiapoptotic Factors

  2001cited by this paper
• Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis.

  2001cited by this paper
• Interleukin-10 up-regulates tumour-necrosis-factor-alpha-related apoptosis-inducing ligand (TRAIL) gene expression in mammary epithelial cells at the involution stage.

  2001cited by this paper
• Tissue inhibitor of metalloproteinase‐4 instigates apoptosis in transformed cardiac fibroblasts

  2001cited by this paper
• Inhibitors of type II 17β-hydroxysteroid dehydrogenase

  2001cited by this paper
• The Focal Adhesion Kinase Suppresses Transformation-associated, Anchorage-independent Apoptosis in Human Breast Cancer Cells

  2000cited by this paper
• The in vitro activity of ADAM‐10 is inhibited by TIMP‐1 and TIMP‐3

  2000cited by this paper
• 17β‐hydroxysteroid dehydrogenases in normal human mammary epithelial cells and breast tissue

  1999cited by this paper
• Effects of Org OD14 (Livial) and its metabolites on 17 beta-hydroxysteroid dehydrogenase activity in hormone-dependent MCF-7 and T-47D breast cancer cells.

  1999cited by this paper
• Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines.

  1999cited by this paper
• Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo

  1999cited by this paper
• A comparative study of the effects of genistein and 2-methoxyestradiol on the proteolytic balance and tumour cell proliferation

  1999cited by this paper
• Tissue inhibitor of metalloproteinase-2 stimulates mesenchymal growth and regulates epithelial branching during morphogenesis of the rat metanephros.

  1999cited by this paper
• High levels of tissue inhibitor of metalloproteinase‐1 predict poor outcome in patients with breast cancer

  1999cited by this paper
• 17Beta-hydroxysteroid dehydrogenases in normal human mammary epithelial cells and breast tissue.

  1999cited by this paper
• Effect of Medrogestone on 17beta-hydroxysteroid dehydrogenase activity in the hormone-dependent MCF-7 and T-47D human breast cancer cell lines.

  1999cited by this paper
• 17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes.

  1999cited by this paper
• Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells.

  1999cited by this paper
• Regulation of estrogen action: role of 17 beta-hydroxysteroid dehydrogenases.

  1999cited by this paper
• Tissue Inhibitor of Metalloproteinase‐2 Induces Apoptosis in Human T Lymphocytes

  1999cited by this paper
• Characterization of molecular and catalytic properties of intact and truncated human 17beta-hydroxysteroid dehydrogenase type 2 enzymes: intracellular localization of the wild-type enzyme in the endoplasmic reticulum.

  1999cited by this paper
• FAK Is the Upstream Signal Protein of the Phosphatidylinositol 3-Kinase-Akt Survival Pathway in Hydrogen Peroxide-induced Apoptosis of a Human Glioblastoma Cell Line*

  1999cited by this paper
• Characterization of Molecular and Catalytic Properties of Intact and Truncated Human 17β-Hydroxysteroid Dehydrogenase Type 2 Enzymes: Intracellular Localization of the Wild-Type Enzyme in the Endoplasmic Reticulum.

  1999cited by this paper
• Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis?

  1998cited by this paper
• In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1.

  1998cited by this paper
• TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

  1998cited by this paper
• Tissue inhibitor of metalloproteinase (TIMP)-1 induces differentiation and an antiapoptotic phenotype in germinal center B cells.

  1998cited by this paper
• TIMP‐2 over‐expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis

  1998cited by this paper
• Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.

  1998cited by this paper
• Functional role of estrogen metabolism in target cells: review and perspectives.

  1998cited by this paper
• Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol.

  1997cited by this paper
• Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.

  1997cited by this paper
• Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat.

  1997cited by this paper
• The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology.

  1997cited by this paper
• Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol

  1997cited by this paper
• The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology

  1997cited by this paper
• Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis*

  1997cited by this paper
• The mammalian metabolite, 2-methoxyestradiol, affects P53 levels and apoptosis induction in transformed cells but not in normal cells.

  1997cited by this paper
• TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells.

  1997cited by this paper
• 2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression.

  1997cited by this paper
• Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

  1997cited by this paper
• Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3.

  1996cited by this paper
• Extracellular matrix signaling from the cellular membrane skeleton to the nuclear skeleton: a model of gene regulation.

  1996cited by this paper
• The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases (*)

  1996cited by this paper
• Synthesis and evaluation of estradiol derivatives with 16α-(bromoalkylamide), 16α-(bromoalkyl) or 16α-(bromoalkynyl) side chain as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 without estrogenic activity

  1996cited by this paper
• Synthesis and evaluation of estradiol derivatives with 16 alpha-(bromoalkylamide), 16 alpha-(bromoalkyl) or 16 alpha-(bromoalkynyl) side chain as inhibitors of 17 beta-hydroxysteroid dehydrogenase type 1 without estrogenic activity.

  1996cited by this paper
• Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene

  1996cited by this paper
• Signal transduction in cell-matrix interactions.

  1996cited by this paper
• Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition.

  1995cited by this paper
• 17β-Hydroxysteroid dehydrogenase activity in endometrial cancer cells: Different metabolic pathways of estradiol in hormone-responsive and non-responsive intact cells

  1995cited by this paper
• Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

  1995cited by this paper
• Signal transduction through integrins: A central role for focal adhesion kinase?

  1995cited by this paper
• 17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium.

  1994cited by this paper
• The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

  1994cited by this paper
• Expression of stromelysin‐1 and timp‐1 in the involuting mammary gland and in early invasive tumors of the mouse

  1994cited by this paper
• Signal transduction from the extracellular matrix

  1993cited by this paper
• Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.

  1993cited by this paper
• Androgen receptor-mediated stimulation of 17 beta-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells.

  1993cited by this paper
• Multiple steroid metabolic pathways in ZR-75-1 human breast cancer cells.

  1991cited by this paper
• Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.

  1990cited by this paper
• Determination of cell number in monolayer cultures.

  1986cited by this paper

• Tissue Inhibitor of Metalloproteinases-1 Overexpression Mediates Chemoresistance in Triple-Negative Breast Cancer Cells

  2023cites this paper
• Functionally enhanced cell spheroids for stem cell therapy: Role of TIMP1 in the survival and therapeutic effectiveness of stem cell spheroids.

  2023cites this paper
• A straightforward method to quantify circulating mRNAs as biomarkers of colorectal cancer

  2023cites this paper
• The angiogenic genes predict prognosis and immune characteristics in esophageal squamous cell carcinoma: Evidence from multi-omics and experimental verification

  2022cites this paper
• Osteoblast Secretome Modulated by Abiraterone Treatment Affects Castration Resistant Prostate Cancer Cell Proliferation

  2022cites this paper
• Association of Exosomal miR-210 with Signaling Pathways Implicated in Lung Cancer

  2021cites this paper
• Regulation of Tumor Metabolism and Extracellular Acidosis by the TIMP-10–CD63 Axis in Breast Carcinoma

  2021cites this paper
• Tissue inhibitor of metalloproteinase-1 (TIMP-1) as a prognostic biomarker in gastrointestinal cancer: a meta-analysis

  2021cites this paper
• Establishment of Structure-Function Relationship of Tissue Inhibitor of Metalloproteinase-1 for Its Interaction with CD63: Implication for Cancer Therapy

  2020cites this paper
• The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling

  2020cites this paper
• Role of Tissue Inhibitor of Matrix Metalloproteinase-1 in the Development of Hypersensitivity Using an Animal Model of Cutaneous Inflammation

  2019cites this paper
• The role of 17βHSDs in breast tissue and breast cancers.

  2019cites this paper
• Recognizing the Molecular Multifunctionality and Interactome of TIMP-1.

  2019cites this paper
• STAT6 knockdown using multiple siRNA sequences inhibits proliferation and induces apoptosis of human colorectal and breast cancer cell lines

  2019cites this paper
• Estradiol Metabolism: Crossroads in Pulmonary Arterial Hypertension

  2019cites this paper
• The culture conditions and outputs from breast cancer cell line in vitro experiments.

  2019cites this paper
• Involvement of TIMP-1 in PECAM-1-mediated tumor dissemination

  2018cites this paper
• Tissue inhibitor of metalloproteinase-1 promotes cell proliferation through YAP/TAZ activation in cancer

  2018cites this paper
• PROGNOSTIC BIOMARKERS IN GASTRIC CANCER

  2018cites this paper
• Photo-modulation of zinc phthalocyanine-treated breast cancer cell line ZR-75-1 inhibited the normal tumor activity in vitro

  2018cites this paper
• Reflections on the evolution of the vertebrate tissue inhibitors of metalloproteinases

  2018cites this paper
• Tissue inhibitor of metalloproteinases 1 enhances rod survival in the rd1 mouse retina

  2018cites this paper
• Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments.

  2017cites this paper
• Extracellular vesicles in lung cancer-From bench to bedside.

  2017cites this paper
• Biomarkers for Early Detection of Acute Kidney Injury.

  2017cites this paper
• Recent Advances in chemistry and pharmacology of 2-methoxyestradiol: An anticancer investigational drug.

  2016cites this paper
• Neurogenic differentiation factor NeuroD confers protection against radiation-induced intestinal injury in mice

  2016cites this paper
• 2‐hydroxyoestradiol and 2‐methoxyoestradiol, two endogenous oestradiol metabolites, induce DNA fragmentation in Sertoli cells

  2016cites this paper
• Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism

  2016cites this paper
• Synthesis of 14ß-cyanomethyl derivatives of estradiol and the estimation of their antineoplastic activity in vitro

  2016cites this paper
• TIMPs: versatile extracellular regulators in cancer

  2016cites this paper
• TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling

  2015cites this paper
• TIMP-1 Inhibits Apoptosis in Lung Adenocarcinoma Cells via Interaction with Bcl-2

  2015influential citation
• The tissue inhibitor of metalloproteinases 1 increases the clonogenic efficiency of human hematopoietic progenitor cells through CD63/PI3K/Akt signaling.

  2015cites this paper
• Erratum: Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

  2015cites this paper
• Down-regulation of TIMP-1 inhibits cell migration, invasion, and metastatic colonization in lung adenocarcinoma

  2015cites this paper
• Novel expression and regulation of TIMP-1 in Epstein Barr virus-infected cells and its impact on cell survival.

  2015cites this paper
• Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease.

  2015cites this paper
• MEDICINAL PLANTS WITH ANTIOXIDANT AND ANTIINFLAMMATORY PROPERTIES IN CANCER PREVENTION by

  2015cites this paper
• Etude de l'interaction du TIMP-1 avec ses récepteurs

  2015cites this paper
• Cardiac fibroblasts protect cardiomyocytes against lethal ischemia-reperfusion injury.

  2014cites this paper
• Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes

  2014cites this paper
• Comparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver disease

  2014cites this paper
• TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling.

  2014cites this paper
• Ovarian Expression, Localization, and Function of Tissue Inhibitor of Metalloproteinase 3 (TIMP3) During the Periovulatory Period of the Human Menstrual Cycle1

  2013cites this paper
• Importance of Hyaluronan-CD44 Signaling in Tumor Progression : Crosstalk with TGFβ and PDGF-BB Signaling

  2013cites this paper
• Analysis Of The Structure And Function Of A Timp-1/cd63 Complex And Its Relationship To An Mt1-Mmp/cd63 Complex

  2013cites this paper
• MOLECULAR MECHANISMS BY WHICH c- ABL AND ARG MEDIATE MELANOMA INVASION AND METASTASIS

  2013cites this paper
• Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation

  2013cites this paper
• Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

  2013cites this paper
• Why are breast cancer stem cells resistant to radiation

  2013cites this paper
• Rôles des cardiofibroblastes dans la protection des cardiomyocytes au cours de l'ischémie-reperfusion

  2013cites this paper
• The TIMP-1 expression in germinal centers of hypertrophied adenoids in children.

  2013cites this paper
• Tissue inhibitor of metalloproteinase 1 (TIMP-1) as a biomarker in gastric cancer: a review

  2013cites this paper
• TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells.

  2013cites this paper
• Human chorionic gonadotropin (hCG) modulation of TIMP1 secretion by human endometrial stromal cells facilitates extravillous trophoblast invasion in vitro.

  2013cites this paper
• Developmental characterization of tissue inhibitor of metalloproteinase domain functions in Xenopus laevis

  2013cites this paper
• Subsequent gene expression pattern in dendritic cells following multiple trauma

  2013cites this paper
• Matrix-leukocyte interactions in liver ischemia-reperfusion injury.

  2012cites this paper
• TIMP‐1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury

  2012cites this paper
• Molecular crosstalk between apoptosis and autophagy induced by a 2-methoxyestradiol analogue (C19) in HeLa cells

  2012cites this paper
• Overexpression of TIMP-1 in Embryonic Stem Cells Attenuates Adverse Cardiac Remodeling following Myocardial Infarction

  2012cites this paper
• Relationships between serum HER2 ECD, TIMP-1 and clinical outcomes in Taiwanese breast cancer

  2012cites this paper
• TIMP-1 Induces an EMT-Like Phenotypic Conversion in MDCK Cells Independent of Its MMP-Inhibitory Domain

  2012influential citation
• Construction of eukaryotic plasmid expressing human TGFBI and its influence on human corneal epithelial cells.

  2012cites this paper
• Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice.

  2012cites this paper
• Nitric Oxide Synthase and Breast Cancer: Role of TIMP-1 in NO-mediated Akt Activation

  2012cites this paper
• Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet

  2012cites this paper
• ROL DE LAS METALOPROTEINASAS Y SUS INHIBIDORES EN PATOLOGÍA TUMORAL

  2012cites this paper
• Tissue inhibitor of metalloproteinase-1 decreased chemosensitivity of MDA-435 breast cancer cells to chemotherapeutic drugs through the PI3K/AKT/NF-кB pathway.

  2011cites this paper
• In vitro effects of an in silico‐modelled 17β‐estradiol derivative in combination with dichloroacetic acid on MCF‐7 and MCF‐12A cells

  2011cites this paper
• Serum TIMP-1 predicts survival outcomes of invasive breast carcinoma patients: a meta-analysis.

  2011cites this paper
• Plasma or serum TIMP-1 is a predictor of survival outcomes in colorectal cancer: a meta-analysis.

  2011cites this paper
• Angiogenesis regulation in hormone dependent breast- and ovarian cancer

  2011cites this paper
• Implication of caspase-3 and granzyme B expression and activity in spleenocytes of ehrlich ascites carcinoma mice subjected to immunotherapy

  2011cites this paper
• BRAFV600E mutation, TIMP-1 upregulation, and NF-κB activation: closing the loop on the papillary thyroid cancer trilogy.

  2011cites this paper
• Mögliche Biomarker des abdominellen Aortenaneurysmas - Matrix Metalloproteinasen-2/9 und Osteoprotegerin

  2011cites this paper
• and NF-kB activation: closing the loop on the papillary thyroid cancer trilogy

  2011cites this paper
• Effects of Estrogen Metabolite 2-Methoxyestradiol on Tumor Suppressor Protein p53 and Proliferation of Breast Cancer Cells

  2011cites this paper
• Hyaluronan Synthase 2 (HAS2) Promotes Breast Cancer Cell Invasion by Suppression of Tissue Metalloproteinase Inhibitor 1 (TIMP-1)*

  2011cites this paper
• Actual Pharmacological Treatment to Reduce Growth of Small Abdominal Aneurysm

  2011cites this paper
• Genetically Modified Es Cells Enhance Cardiac Repair And Regeneration In The Infarcted Heart

  2011cites this paper
• Tissue inhibitor of metalloproteinase-1 promotes NIH3T3 fibroblast proliferation by activating p-Akt and cell cycle progression

  2011cites this paper
• Prognostic significance of TIMP-1 in non-small cell lung cancer.

  2011cites this paper
• Genistein induces enhanced growth promotion in ER-positive/erbB-2-overexpressing breast cancers by ER-erbB-2 cross talk and p27/kip1 downregulation.

  2010cites this paper
• The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity.

  2010cites this paper
• Suppressive effect of dexamethasone on TIMP-1 production involves murine osteoblastic MC3T3-E1 cell apoptosis

  2010cites this paper
• Control of death receptor ligand activity by posttranslational

  2010cites this paper
• Control of death receptor ligand activity by posttranslational modifications

  2010cites this paper
• HER2, TOP2A, and TIMP-1 and responsiveness to adjuvant anthracycline-containing chemotherapy in high-risk breast cancer patients.

  2010cites this paper
• Immunohistochemical Expression of Stem Cell, Endothelial Cell, and Chemosensitivity Markers in Primary Glioma Spheroids Cultured in Serum‐Containing and Serum‐Free Medium

  2010cites this paper
• Matrix Metalloproteinases and their Inhibitors – Friend or Foe

  2010cites this paper
• 2-Methoxyestradiol--biology and mechanism of action.

  2010cites this paper
• TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs.

  2009cites this paper
• Immunohistochemical Study of Matrix Metalloproteinase 9 and Tissue Inhibitor of Matrix Metalloproteinase 1 in Benign and Malignant Breast Tissue – Strong Expression in Intraductal Carcinomas of the Breast

  2009cites this paper
• Interaction Between Retinoids and Eicosanoids: Their Relevance to Cancer Chemoprevention

  2009cites this paper
• Inhibitory effect of immature plum on PMA-induced MMP-9 expression in human hepatocellular carcinoma

  2009cites this paper
• Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course.

  2009cites this paper
• Mitochondrial inside-out signalling during alkylating agent-induced anoikis.

  2009cites this paper
• Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells.

  2009cites this paper