Apoptotic cell death and efferocytosis in atherosclerosis.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2012-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/ATVBAHA.111.224873PMID 22328779
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Constitutive exposure of phosphatidylserine on viable cells

  2011cited by this paper
• Autophagy in Atherosclerosis: A Potential Drug Target for Plaque Stabilization

  2011cited by this paper
• Apoptosis Signal–Regulating Kinase 1 Deficiency Accelerates Hyperlipidemia-Induced Atheromatous Plaques via Suppression of Macrophage Apoptosis

  2011cited by this paper
• Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

  2011cited by this paper
• The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis

  2011cited by this paper
• Immunohistochemical characterisation of dendritic cells in human atherosclerotic lesions: possible pitfalls

  2011cited by this paper
• Cell death, damage-associated molecular patterns, and sterile inflammation in cardiovascular disease.

  2011cited by this paper
• High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice

  2011cited by this paper
• Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells

  2010influential reference
• Molecular mechanisms of late apoptotic/necrotic cell clearance

  2010influential reference
• Mechanisms of failed apoptotic cell clearance by phagocyte subsets in cardiovascular disease

  2010cited by this paper
• Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans.

  2009cited by this paper
• Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.

  2009cited by this paper
• Immunogenic and tolerogenic cell death

  2009cited by this paper
• G2A Deficiency in Mice Promotes Macrophage Activation and Atherosclerosis

  2009cited by this paper
• PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

  2009cited by this paper
• Brief Report: Increased Apoptosis in Advanced Atherosclerotic Lesions of Apoe−/− Mice Lacking Macrophage Bcl-2

  2009cited by this paper
• Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

  2009cited by this paper
• Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

  2009cited by this paper
• Subclinical atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus.

  2008cited by this paper
• Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis.

  2008cited by this paper
• Defective Mer Receptor Tyrosine Kinase Signaling in Bone Marrow Cells Promotes Apoptotic Cell Accumulation and Accelerates Atherosclerosis

  2008cited by this paper
• Clearance of apoptotic cells by phagocytes.

  2008cited by this paper
• Clearance of apoptotic cells by phagocytes

  2008cited by this paper
• Macrophage Apoptosis Exerts Divergent Effects on Atherogenesis as a Function of Lesion Stage

  2008cited by this paper
• Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe−/− Mice

  2008cited by this paper
• Innate apoptotic immunity: the calming touch of death

  2008cited by this paper
• Abstract 3968: Bone Marrow Derived Growth Differentiation Factor-15 (GDF-15) Protects from Macrophage Accumulation and Effects Atherosclerotic Lesion Stabilisation in Low-Density Lipoprotein Receptor-Null Mice

  2008cited by this paper
• Engulfment of apoptotic cells: signals for a good meal

  2007influential reference
• MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF.

  2007cited by this paper
• Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

  2007cited by this paper
• TAM receptors are pleiotropic inhibitors of the innate immune response.

  2007cited by this paper
• Complement C1q reduces early atherosclerosis in low-density lipoprotein receptor-deficient mice.

  2007cited by this paper
• Dielectrophoretic detection of membrane morphology changes in Jurkat T-cells undergoing etoposide-induced apoptosis.

  2007cited by this paper
• Cytokines in atherosclerosis: pathogenic and regulatory pathways.

  2006cited by this paper
• Cholesterol-induced Apoptotic Macrophages Elicit an Inflammatory Response in Phagocytes, Which Is Partially Attenuated by the Mer Receptor*

  2006cited by this paper
• Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

  2006cited by this paper
• Recognition ligands on apoptotic cells: a perspective

  2006cited by this paper
• Leukocyte Transglutaminase 2 Expression Limits Atherosclerotic Lesion Size

  2005cited by this paper
• Phagocytosis of Apoptotic Cells by Macrophages Is Impaired in Atherosclerosis

  2005cited by this paper
• Reduced ABCA1-Mediated Cholesterol Efflux and Accelerated Atherosclerosis in Apolipoprotein E–Deficient Mice Lacking Macrophage-Derived ACAT1

  2005cited by this paper
• IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo

  2005influential reference
• Apoptotic Cells Initiate Endothelial Cell Sprouting via Electrostatic Signaling

  2005cited by this paper
• Masking of Phosphatidylserine Inhibits Apoptotic Cell Engulfment and Induces Autoantibody Production in Mice

  2004cited by this paper
• New aspects in the pathogenesis of diabetic atherothrombosis.

  2004cited by this paper
• Persistence of apoptotic cells without autoimmune disease or inflammation in CD14−/− mice

  2004cited by this paper
• Apoptotic Cells with Oxidation-specific Epitopes Are Immunogenic and Proinflammatory

  2004cited by this paper
• Caspase-3 and Tissue Factor Expression in Lipid-Rich Plaque Macrophages: Evidence for Apoptosis as Link Between Inflammation and Atherothrombosis

  2004cited by this paper
• Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease

  2004cited by this paper
• Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

  2004cited by this paper
• Reduced Macrophage Apoptosis Is Associated With Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice

  2004cited by this paper
• [Cloning and expression analysis in mature individuals of salmon gonadotropin-releasing hormone (sGnRH) gene in common carp].

  2004cited by this paper
• Apolipoprotein E Modulates Clearance of Apoptotic Bodies In Vitro and In Vivo, Resulting in a Systemic Proinflammatory State in Apolipoprotein E-Deficient Mice1

  2004cited by this paper
• Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

  2003cited by this paper
• Protective Role of Uncoupling Protein 2 in Atherosclerosis

  2003cited by this paper
• Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase

  2002cited by this paper
• A blast from the past: clearance of apoptotic cells regulates immune responses

  2002cited by this paper
• Immunobiology of dendritic cells.

  2000cited by this paper
• Apoptosis in the vasculature: mechanisms and functional importance

  2000influential reference
• Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death.

  2000cited by this paper
• Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques.

  2000cited by this paper
• Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions.

  2000cited by this paper
• C1q Deficiency and Autoimmunity: The Effects of Genetic Background on Disease Expression1

  2000cited by this paper
• Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo.

  1999cited by this paper
• Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity.

  1999cited by this paper
• Apoptosis in human atherosclerotic plaques

  1999cited by this paper
• Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis.

  1999cited by this paper
• Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition.

  1999cited by this paper
• Tissue factor modulates the thrombogenicity of human atherosclerotic plaques.

  1997cited by this paper
• Immunosuppressive effects of apoptotic cells

  1997cited by this paper
• Macrophages, smooth muscle cells, and tissue factor in unstable angina. Implications for cell-mediated thrombogenicity in acute coronary syndromes.

  1996cited by this paper
• Specific contribution of different phospholipid surfaces to the activation of prothrombin by the fully assembled prothrombinase.

  1993cited by this paper
• Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

  1972cited by this paper

• Restoring immune homeostasis in atherosclerotic plaques via inorganic violet phosphorus nano-immunotherapy

  2026cites this paper
• Identification and validation of efferocytosis-related biomarkers for the diagnosis of atherosclerosis based on bioinformatics and machine learning

  2025cites this paper
• Molecular imaging of cardiovascular disease: Current status and future perspective.

  2025cites this paper
• Allograft Inflammatory Factor-1 induces the dedifferentiation of Vascular Smooth Muscle cells into a macrophage-like phenotype both in vivo and in vitro.

  2025cites this paper
• Atherosclerosis in the Context of Hemostasis and Neovascularization - Current State of Knowledge.

  2025cites this paper
• Apolipoprotein A1 deficiency increases macrophage apoptosis and necrotic core development in atherosclerotic plaques in a Bim-dependent manner

  2025cites this paper
• Role of efferocytosis in chronic pain -- From molecular perspective.

  2025cites this paper
• Macrophage efferocytosis: Mechanisms and therapeutic opportunities for future cardiovascular diseases.

  2025cites this paper
• Association of Quantitative Coronary Artery Calcium Density Subtype Volumes With Major Adverse Cardiovascular Events

  2025cites this paper
• Advection-dominated models of atherosclerotic plaque composition: The impacts of cell death and cholesterol toxicity.

  2025cites this paper
• Crosstalk between Inflammation and Atherosclerosis in Rheumatoid Arthritis and Systemic Lupus Erythematosus: Is There a Common Basis?

  2024cites this paper
• Biomechanics-mediated endocytosis in atherosclerosis

  2024cites this paper
• Modeling human atherosclerotic lesions in the test tube: Are we there yet?

  2024cites this paper
• High plasma levels of fortilin are associated with cardiovascular events in patients undergoing coronary angiography

  2024cites this paper
• Intracellular and extracellular synergistic therapy for restoring macrophage functions via anti-CD47 antibody-conjugated bifunctional nanoparticles in atherosclerosis

  2024cites this paper
• Overview of Vascular Smooth Muscle Cells, Endothelial Cells, and Macrophages Apoptosis During Atherosclerosis Development

  2024cites this paper
• The role of metabolic disorders in the development of atherosclerosis.

  2024cites this paper
• Mechanism of Zhishi Xiebai Guizhi Decoction to treat atherosclerosis: insights into experiments, network pharmacology and molecular docking.

  2024cites this paper
• Invasive coronary imaging of inflammation to further characterize high-risk lesions: what options do we have?

  2024cites this paper
• Polymorphic variants of the genes for enzymes of the antioxidant system, apoptosis and inflammation as potential predictors of myocardial infarction

  2024cites this paper
• Clearing the Path: Exploring Apoptotic Cell Clearance in Inflammatory and Autoimmune Disorders for Therapeutic Advancements

  2024cites this paper
• MAFLD: a multisystem disease

  2023cites this paper
• A cyclic azapeptide ligand of the scavenger receptor CD36/SR-B2 reduces the atherosclerotic lesion progression and enhances plaque stability in apolipoprotein E-deficient mice

  2023cites this paper
• The Role of Punicalagin and Its Metabolites in Atherosclerosis and Risk Factors Associated with the Disease

  2023cites this paper
• Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

  2023cites this paper
• CTRP4 ameliorates inflammation, thereby attenuating the interaction between HUVECs and THP-1 monocytes through SIRT6/Nrf2 signaling.

  2023cites this paper
• Seeing Beyond Apoptosis: Ultrastructural Aspects of Necrosis in Human Atherosclerosis

  2023cites this paper
• Efferocytosis: An Emerging Therapeutic Strategy for Type 2 Diabetes Mellitus and Diabetes Complications

  2023cites this paper
• [Genetic inhibition of CARD9 in mice accelerates the development of atherosclerosis through CD36-dependent defective autophagy].

  2023cites this paper
• Cellular Mechanisms of Singlet Oxygen in Photodynamic Therapy

  2023cites this paper
• Exploration of Hub Genes and Pathogenetic Pathways in Systemic Lupus Erythematosus Complicated with Early Onset Atherosclerosis

  2023cites this paper
• Macrophage Anti-inflammatory Behaviour in a Multiphase Model of Atherosclerotic Plaque Development

  2022cites this paper
• The effect of endurance exercise and rosehip extract supplementation on the expression of P53 and cytochrome C genes in male rat heart

  2022cites this paper
• High Plasma Levels of Fortilin in Patients with Coronary Artery Disease

  2022influential citation
• Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis: Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study.

  2022cites this paper
• Rubicon promotes the M2 polarization of Kupffer cells via LC3-associated phagocytosis-mediated clearance to improve liver transplantation.

  2022cites this paper
• Genetic inhibition of CARD9 accelerates the development of experimental atherosclerosis through CD36 dependent-defective autophagy

  2022cites this paper
• Recent advance in treatment of atherosclerosis: Key targets and plaque-positioned delivery strategies

  2022cites this paper
• Programmed cell death in atherosclerosis and vascular calcification

  2022cites this paper
• Advances in Anti-Metabolic Disease Treatments Targeting CD47.

  2022cites this paper
• Actualités dans la physiopathologie de l'athérosclérose

  2022cites this paper
• Hyperglycaemia-associated Caspase-3 predicts diabetes and coronary artery disease events

  2021cites this paper
• Rare Modifier Variants Alter the Severity of Cardiovascular Disease in Pseudoxanthoma Elasticum: Identification of Novel Candidate Modifier Genes and Disease Pathways Through Mixture of Effects Analysis

  2021cites this paper
• Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations

  2021cites this paper
• Cyclophilin A induces macrophage apoptosis and enhances atherosclerotic lesions in high‐fat diet‐fed hyperglycemic rabbits

  2021cites this paper
• Cyclophilin A Impairs Efferocytosis and Accelerates Atherosclerosis by Overexpressing CD 47 and Down-Regulating Calreticulin

  2021cites this paper
• Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential

  2021cites this paper
• Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients

  2021cites this paper
• Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions

  2021cites this paper
• Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach

  2021cites this paper
• Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages

  2021cites this paper
• Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer

  2021cites this paper
• Cyclophilin A induces macrophage apoptosis and enhances atherosclerotic lesions in highâ•’fat dietâ•’fed hyperglycemic rabbits

  2021cites this paper
• Naoxintong accelerates diabetic wound healing by attenuating inflammatory response

  2021cites this paper
• Human Atherosclerotic Plaque Progression Is Dependent on Apoptosis According to Bomb-Pulse 14C Dating

  2021cites this paper
• The Dynamics of B Cell Aging in Health and Disease

  2021cites this paper
• Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis.

  2020cites this paper
• Title page Title: PTX3 activates classic complement pathway and mediates phagocytosis of cholesterol-induced apoptotic macrophages in atherosclerosis Running Title: PTX3 activates classic complement pathway

  2020cites this paper
• Physiopathologie de l’athérosclérose

  2020cites this paper
• CTRP9 alleviates foam cells apoptosis by enhancing cholesterol efflux.

  2020cites this paper
• Downregulation of Sirt1 is correlated to upregulation of p53 and increased apoptosis in epicardial adipose tissue of patients with coronary artery disease

  2020cites this paper
• Macrophage Biology in Cardiovascular Diseases.

  2020cites this paper
• AIM2 Stimulation Impairs Reendothelialization and Promotes the Development of Atherosclerosis in Mice

  2020cites this paper
• Protocatechuic Acid Inhibits Vulnerable Atherosclerotic Lesion Progression in Older Apoe-/- Mice.

  2020cites this paper
• Toll-Like Receptor 7 Stimulation Promotes the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice.

  2020cites this paper
• Regulation of efferocytosis by caspase-dependent apoptotic cell death in atherosclerosis.

  2020cites this paper
• Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis

  2020cites this paper
• The biology of vascular calcification.

  2020cites this paper
• Nanoparticle-Based Approaches towards the Treatment of Atherosclerosis

  2020cites this paper
• Platelets as therapeutic targets to prevent atherosclerosis.

  2020cites this paper
• A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus

  2020cites this paper
• Accelerated Atherosclerosis in Rheumatoid Arthritis: Mechanisms and Treatment.

  2019cites this paper
• MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.

  2019cites this paper
• Rhodiola and salidroside in the treatment of metabolic disorders.

  2019cites this paper
• Immune-Inflammation in Atherosclerosis: A New Twist In An Old Tale.

  2019cites this paper
• Stabilin Receptors: Role as Phosphatidylserine Receptors

  2019cites this paper
• TAM receptors in cardiovascular disease

  2019cites this paper
• Allograft inflammatory factor-1, a multi-target regulator of atherosclerosis.

  2019cites this paper
• Hydrogen sulfide stabilizes atherosclerotic plaques in apolipoprotein E knockout mice.

  2019cites this paper
• Molecular mechanisms of cell death and cell clearance

  2019influential citation
• Increased cardiovascular and atherosclerosis markers in blood of older atopic dermatitis patients.

  2019cites this paper
• LongShengZhi Capsule Reduces Established Atherosclerotic Lesions in apoE-Deficient Mice by Ameliorating Hepatic Lipid Metabolism and Inhibiting Inflammation

  2019cites this paper
• Systemic lupus erythematosus and endothelial dysfunction: a close relationship.

  2019cites this paper
• Arterial Aging and Age-Associated Arterial Diseases

  2019influential citation
• Perilipin 5 deficiency promotes atherosclerosis progression through accelerating inflammation, apoptosis, and oxidative stress

  2019cites this paper
• Apoptotic cell clearance in the tumor microenvironment: a potential cancer therapeutic target

  2019cites this paper
• Frontiers in PET imaging of the vulnerable atherosclerotic plaque.

  2019cites this paper
• Induction of HLA-A2 restricted CD8 T cell responses against ApoB100 peptides does not affect atherosclerosis in a humanized mouse model

  2019cites this paper
• Scavenger receptor A1 attenuates aortic dissection via promoting efferocytosis in macrophages.

  2019cites this paper
• Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through the AT1R/ROS/p38 MAPK/ADAM17 pathway

  2019cites this paper
• Development of immunohistochemical triple staining method for the evaluation of different types of cell death in coronary thrombus

  2019cites this paper
• Naringenin enhances the regression of atherosclerosis induced by a chow diet in Ldlr-/- mice.

  2019cites this paper
• sTRAIL-R2 (Soluble TNF [Tumor Necrosis Factor]-Related Apoptosis-Inducing Ligand Receptor 2) a Marker of Plaque Cell Apoptosis and Cardiovascular Events.

  2019cites this paper
• Traditional Chinese medication Tongxinluo attenuates apoptosis in ox-LDL-stimulated macrophages by enhancing Beclin-1-induced autophagy.

  2018cites this paper
• 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Alleviates Atherosclerosis via Enhancing Efferocytosis and Facilitating a Shift in the Th1/Th2 Balance Toward Th2 Polarization

  2018cites this paper
• THE ROLE OF ACTIVATED THROMBIN-ACTIVABLE FIBRINOLYSIS INHIBITOR (TAFIA) IN ATHEROSCLEROSIS PROGRESSION THE ROLE OF ACTIVATED THROMBIN-ACTIVABLE FIBRINOLYSIS INHIBITOR (TAFIA) IN ATHEROSCLEROSIS PROGRESSION By DHULFIHA MUZAFAR GANI, B.H.Sc. (Hons)

  2018cites this paper
• Cardiovascular disease in systemic lupus erythematosus is associated with increased levels of biomarkers reflecting receptor-activated apoptosis.

  2018cites this paper
• FADD (Fas-Associated Protein With Death Domain), Caspase-3, and Caspase-8 and Incidence of Ischemic Stroke

  2018cites this paper
• Biologic bases of residual risk of cardiovascular events: A flawed concept

  2018cites this paper
• Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis

  2018cites this paper