Pannexin hemichannels: A novel promising therapy target for oxidative stress related diseases

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Journal of Cellular Physiology

• Publication date

  2018-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/jcp.25906PMID 28295275
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High Relative Expression of Pannexin 3 (PANX3) in an Axillary Sweat Gland Carcinoma With Osteosarcomatous Transformation.

  2016cited by this paper
• Purinergic Signaling in Gut Inflammation: The Role of Connexins and Pannexins

  2016cited by this paper
• Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death.

  2016cited by this paper
• Endothelial Dysfunction and Hypertension.

  2016cited by this paper
• Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer

  2016cited by this paper
• Pannexin-1 Deficient Mice Have an Increased Susceptibility for Atrial Fibrillation and Show a QT-Prolongation Phenotype

  2016cited by this paper
• Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity.

  2016cited by this paper
• Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases

  2016cited by this paper
• Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease

  2016cited by this paper
• Altered physiological functions and ion currents in atrial fibroblasts from patients with chronic atrial fibrillation

  2016cited by this paper
• Dual Oxidase 2 (Duox2) Regulates Pannexin 1-mediated ATP Release in Primary Human Airway Epithelial Cells via Changes in Intracellular pH and Not H2O2 Production*

  2016influential reference
• H2O2 and Ca2+-based signaling and associated ion accumulation, antioxidant systems and secondary metabolism orchestrate the response to NaCl stress in perennial ryegrass

  2016cited by this paper
• Inhibition of lanthanide nanocrystal-induced inflammasome activation in macrophages by a surface coating peptide through abrogation of ROS production and TRPM2-mediated Ca(2+) influx.

  2016cited by this paper
• Peroxiredoxin 5 prevents amyloid-beta oligomer-induced neuronal cell death by inhibiting ERK-Drp1-mediated mitochondrial fragmentation.

  2016cited by this paper
• The Chinese Herbal Medicine Formula mKG Suppresses Pulmonary Fibrosis of Mice Induced by Bleomycin

  2016cited by this paper
• Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium

  2016cited by this paper
• Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases

  2016cited by this paper
• High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure

  2016cited by this paper
• Connexin and pannexin channels in cancer

  2016cited by this paper
• Dynamic Regulation of Cell Volume and Extracellular ATP of Human Erythrocytes

  2016cited by this paper
• A new perspective of mechanosensitive pannexin-1 channels in cancer metastasis: clues for the treatment of other stress-induced diseases.

  2016cited by this paper
• Nitric oxide inhibits the pannexin 1 channel through a cGMP-PKG dependent pathway.

  2015cited by this paper
• Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons

  2015cited by this paper
• Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes

  2015cited by this paper
• Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion

  2015cited by this paper
• Pannexin‐2 is expressed in the human colon with extensive localization in the enteric nervous system

  2015cited by this paper
• The Role of Oxidative Stress and Autophagy in Atherosclerosis

  2015cited by this paper
• Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

  2015cited by this paper
• Blockade of P2X7 Receptors or Pannexin-1 Channels Similarly Attenuates Postischemic Damage

  2015cited by this paper
• Mitochondrial oxidative stress promotes atrial fibrillation

  2015cited by this paper
• Probenecid Application Prevents Clinical Symptoms and Inflammation in Experimental Autoimmune Encephalomyelitis

  2015cited by this paper
• ROS Production via P2Y1-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells

  2015cited by this paper
• Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway

  2015cited by this paper
• Pannexin-1 channels and their emerging functions in cardiovascular diseases.

  2015cited by this paper
• Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes

  2015cited by this paper
• Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death

  2015cited by this paper
• Role of Connexins and Pannexins in the Pancreas.

  2015cited by this paper
• Pannexin‑1 silencing inhibits the proliferation of U87‑MG cells.

  2015cited by this paper
• Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease

  2015cited by this paper
• Functional role of a polymorphism in the Pannexin1 gene in collageninduced platelet aggregation

  2015cited by this paper
• Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival

  2015cited by this paper
• Pannexin 1 facilitates arterial relaxation via an endothelium‐derived hyperpolarization mechanism

  2015cited by this paper
• Serotonin in Parkinson's disease.

  2015cited by this paper
• Integrated analysis of gene expression and DNA methylation changes induced by hepatocyte growth factor in human hepatocytes

  2015cited by this paper
• Nonmetal haptens induce ATP release from keratinocytes through opening of pannexin hemichannels by reactive oxygen species.

  2014cited by this paper
• Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung

  2014influential reference
• Amplification of human platelet activation by surface pannexin-1 channels

  2014cited by this paper
• The role of reactive oxygen species and metabolism on cancer cells and their microenvironment.

  2014cited by this paper
• Angiotensin II mobilizes intracellular calcium and activates pannexin‐1 channels in rat carotid body type II cells via AT1 receptors

  2014cited by this paper
• Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

  2014cited by this paper
• Pannexin channels and their links to human disease.

  2014cited by this paper
• Pannexin1 channels act downstream of P2X7 receptors in ATP-induced murine T-cell death

  2014cited by this paper
• Probenecid reduces infection and inflammation in acute Pseudomonas aeruginosa pneumonia.

  2014cited by this paper
• NADPH Oxidases in Vascular Pathology

  2014cited by this paper
• Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-independent Mechanism*

  2014cited by this paper
• Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease.

  2014cited by this paper
• NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII.

  2014cited by this paper
• Chloride intracellular channel 1 regulates colon cancer cell migration and invasion through ROS/ERK pathway.

  2014cited by this paper
• Regulation of Hemichannels and Gap Junction Channels by Cytokines in Antigen-Presenting Cells

  2014cited by this paper
• Nucleotides Released From Palmitate-Challenged Muscle Cells Through Pannexin-3 Attract Monocytes

  2014cited by this paper
• Monitoring oxidative stress during chronic obstructive pulmonary disease exacerbations using malondialdehyde

  2014cited by this paper
• Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases

  2014cited by this paper
• Hemichannels: new roles in astroglial function

  2014cited by this paper
• Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

  2013cited by this paper
• Probenecid Protects Against Transient Focal Cerebral Ischemic Injury by Inhibiting HMGB1 Release and Attenuating AQP4 Expression in Mice

  2013cited by this paper
• Molecular mechanisms of ATP secretion during immunogenic cell death

  2013cited by this paper
• P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

  2013influential reference
• Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

  2013cited by this paper
• Expression and localization of pannexin‐1 hemichannels in human colon in health and disease

  2013cited by this paper
• Oxidative stress in COPD.

  2013influential reference
• TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves.

  2013cited by this paper
• Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients

  2013cited by this paper
• Histamine Induces ATP Release from Human Subcutaneous Fibroblasts, via Pannexin-1 Hemichannels, Leading to Ca2+ Mobilization and Cell Proliferation*

  2013cited by this paper
• The Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis Offers Efficient Bystander Cell Killing for Suicide Gene Therapy of Cancer

  2013cited by this paper
• Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer.

  2013cited by this paper
• RETRACTED ARTICLE: Reactive oxygen species and tumor metastasis

  2013cited by this paper
• Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy

  2012cited by this paper
• Activation of neuronal P2X7 receptor-Pannexin-1 mediates death of enteric neurons during colitis

  2012cited by this paper
• ATP Release from Dying Autophagic Cells and Their Phagocytosis Are Crucial for Inflammasome Activation in Macrophages

  2012cited by this paper
• Pannexin: from discovery to bedside in 11±4 years?

  2012cited by this paper
• Pannexin 1 in the regulation of vascular tone.

  2012cited by this paper
• Genetic Ablation of Pannexin1 Protects Retinal Neurons from Ischemic Injury

  2012cited by this paper
• Increased Expression of Nox1 in Neointimal Smooth Muscle Cells Promotes Activation of Matrix Metalloproteinase-9

  2012cited by this paper
• Pannexin1 Drives Multicellular Aggregate Compaction via a Signaling Cascade That Remodels the Actin Cytoskeleton*

  2012cited by this paper
• Prevalence of Symptoms Meeting Criteria for Irritable Bowel Syndrome in Inflammatory Bowel Disease: Systematic Review and Meta-Analysis

  2012influential reference
• P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury

  2012cited by this paper
• Pannexin1 Stabilizes Synaptic Plasticity and Is Needed for Learning

  2012cited by this paper
• Nox1 transactivation of epidermal growth factor receptor promotes N-cadherin shedding and smooth muscle cell migration.

  2012cited by this paper
• Patterns of heterogeneous expression of pannexin 1 and pannexin 2 transcripts in the olfactory epithelium and olfactory bulb

  2012cited by this paper
• Mechanisms of ATP release and signalling in the blood vessel wall.

  2012cited by this paper
• Neutral sphingomyelinase activation precedes NADPH oxidase‐dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor‐α

  2012cited by this paper
• Stretch of atrial myocytes stimulates recruitment of macrophages via ATP released through gap-junction channels.

  2012cited by this paper
• Thrombin-induced ATP release from human umbilical vein endothelial cells.

  2012influential reference
• Pannexin1 and Pannexin3 Exhibit Distinct Localization Patterns in Human Skin Appendages and are Regulated during Keratinocyte Differentiation and Carcinogenesis

  2012cited by this paper
• S-Nitrosylation Inhibits Pannexin 1 Channel Function*

  2012cited by this paper
• Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation.

  2012influential reference
• Tales of a Dirty Drug: Carbenoxolone, Gap Junctions, and Seizures

  2012cited by this paper
• Interaction between nitric oxide signaling and gap junctions: effects on vascular function.

  2012cited by this paper
• Loss of Pannexin 1 Attenuates Melanoma Progression by Reversion to a Melanocytic Phenotype*

  2012cited by this paper
• ATP signaling is deficient in cultured pannexin1‐null mouse astrocytes

  2012cited by this paper

• Turtle shell as a health food ingredient: a review of global utilization, nutritients, health benefits, and functional food potential

  2026cites this paper
• Pannexin1 Inhibition Suppresses Porphyromonas gingivalis-Induced Ferroptosis in Peri-Implantitis by Regulating the NRF2/SLC7A11/GPX4 Pathway.

  2026cites this paper
• Inhibition of Pannexin1 alleviates the damage of pilocarpine-induced status epilepticus through diminishing inflammatory PANoptosis-like neuron death.

  2025cites this paper
• Contribution of inwardly rectifying potassium channel 4.1 in orofacial neuropathic pain: Regulation of pannexin 3 via the reactive oxygen species‐activated P38 MAPK signal pathway

  2024cites this paper
• Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

  2024cites this paper
• Hemichannels contribute to mitochondrial Ca2+ and morphology alterations evoked by ethanol in astrocytes

  2024cites this paper
• Loss of Panx1 function in zebrafish alters motor behavior in a lab‐on‐chip model of Parkinson's disease

  2023cites this paper
• Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts.

  2023cites this paper
• Exogenous spermidine alleviates diabetic cardiomyopathy via suppressing reactive oxygen species, endoplasmic reticulum stress, and Pannexin-1-mediated ferroptosis

  2023cites this paper
• Possible role of pannexin 1 channels and purinergic receptors in the pathogenesis and mechanism of action of SARS-CoV-2 and therapeutic potential of targeting them in COVID-19

  2022influential citation
• Targeting ferroptosis in ischemia/reperfusion renal injury

  2022cites this paper
• Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy.

  2022cites this paper
• Herb-partitioned moxibustion alleviates colonic inflammation in Crohn’s disease rats by inhibiting hyperactivation of the NLRP3 inflammasome via regulation of the P2X7R-Pannexin-1 signaling pathway

  2021influential citation
• Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders

  2020cites this paper
• Blocking pannexin1 reduces airway inflammation in a murine model of asthma.

  2020cites this paper
• Pannexin-2, a novel mitochondrial-associated membrane protein, may become the new strategy to treat and prevent neurological disorders.

  2020cites this paper
• The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract

  2020cites this paper
• Mitochondrial Dysfunction as Substrate for Arrhythmogenic Cardiomyopathy: A Search for New Disease Mechanisms

  2019cites this paper
• Phenotypic chemical and mutant screening of zebrafish larvae using an on-demand response to electric stimulation.

  2019cites this paper
• Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury

  2019cites this paper
• Destination and consequences of Panx1 and mutant expression in polarized MDCK cells.

  2019cites this paper
• The role and therapeutic potential of connexins, pannexins and their channels in Parkinson's disease.

  2019cites this paper
• The interaction of SiO2 nanoparticles with the neuronal cell membrane: activation of ionic channels and calcium influx.

  2019cites this paper
• Therapeutic strategies targeting connexins

  2018cites this paper
• Fullerene Based Nanomaterials for Biomedical Applications

  2018cites this paper
• Effects of TRPM2 Inhibition in Neuroprotection following

  2017cites this paper
• Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd3N@C80: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.

  2017cites this paper
• The Oxidative Stress Response in Elite Water Polo Players: Effects of Genetic Background

  2017cites this paper