Comparative genomics and multiomics analyses reveal the evolution and physiological basis of rubber biosynthesis in Hevea species

Abstract Background There are multiple species within the Hevea genus, each exhibiting distinct characteristics, but many remain underexplored due to their lower latex productivity. While Hevea brasiliensis is the primary source of natural rubber, other Hevea species represent valuable gene pools that could be leveraged in breeding programs to enhance latex yield, biosynthesis efficiency, and the physicochemical properties of latex. With increasing interest in enhancing natural rubber traits, these lesser-known species are being revisited for their underexplored genetic diversity. Results In this study, we performed a pangene analysis of 6 Hevea species and varieties, integrating proteomic and lipidomic data to investigate genetic and metabolic variation related to rubber biosynthesis and latex composition. The pangene analysis revealed conserved and expanded ATP-related functions, underscoring ATP’s role in latex production. The proteomic data identified key enzymes involved in rubber biosynthesis and differentially abundant proteins related to latex regeneration, suggesting that regeneration capacity may influence yield efficiency. Lipidomic profiling uncovered species-specific lipid compositions associated with membrane dynamics and rubber particle stability, which may contribute to latex properties. Conclusions These findings provide valuable insights into Hevea’s genomic and metabolic diversity, supporting future breeding programs aimed at improving natural rubber production and its performance in various applications.

• Publication year

  2025

• Venue

  GigaScience

• Publication date

  2025-01-06

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1093/gigascience/giaf115PMID 41070844PMCID 12512020
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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