Alcohol addiction and Alzheimer’s disease: a molecular collision course

Chronic alcohol consumption is increasingly recognized as a risk factor for Alzheimer’s disease (AD), contributing to cognitive decline through multiple biological pathways. Excessive alcohol intake accelerates neurodegeneration by impairing the brain’s ability to clear toxic proteins, disrupting neurotransmitter balance, and exacerbating inflammation and oxidative stress. These effects collectively weaken neuronal resilience, making the brain more vulnerable to AD-related damage. Emerging therapeutic strategies focus on mitigating alcohol-induced harm through neuroprotective drugs, inflammation-targeting treatments, and neurotransmitter modulators. Lifestyle-based interventions, including early abstinence, cognitive training, and precision nutrition, also show promise in reducing risk and slowing disease progression. Future research should prioritize personalized treatment approaches and novel drug delivery methods to improve outcomes for individuals affected by both conditions.

• Publication year

  2025

• Venue

  Translational Psychiatry

• Publication date

  2025-10-17

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/s41398-025-03619-6PMID 41107250PMCID 12534461
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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