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Unraveling the mechanistic links between blood pressure regulation and calcium-magnesium homeostasis: Insights into hypertension, hyperparathyroidism, and mineral disorders

Pritha Dutta,Anita T. Layton

Published 2025 in bioRxiv

ABSTRACT

The systems regulating blood pressure and calcium-magnesium (Ca2+-Mg2+) homeostasis are increasingly recognized to have significant, clinically relevant interactions, where alterations in one can lead to significant changes in the other. In this study, we developed a computational model integrating blood pressure regulation and Ca2□-Mg2□ homeostasis in a male rat. We simulated various conditions, including hypertension, Ca2□, Mg2□, and vitamin D3 deficiencies, and primary hyperparathyroidism. Simulations of hypertension, induced by various stimuli like increased renin or aldosterone secretion, demonstrated significant effects on parathyroid hormone (PTH), calcitriol, renal Ca2□/Mg2□ handling, and bone resorption. Dietary Ca2□, Mg2□, and vitamin D3 deficiencies elevated mean arterial pressure, with Mg2□ deficiency having a stronger effect. Furthermore, the model predicted that primary hyperparathyroidism elevates PTH, Ca2□, and calcitriol, leading to increased mean arterial pressure and bone loss. Overall, this model provides valuable insights into the mechanistic links between blood pressure regulation and Ca2□-Mg2□ homeostasis, offering insights into clinical conditions like hypertension and hyperparathyroidism.

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