Harnessing Photochemistry in Natural Product Synthesis: From Strategy to Applications

Photochemistry and total synthesis are deeply rooted in the history of organic chemistry, each developing independently while also intersecting frequently. Indeed, mild reaction conditions, versatility of transformations, and complementary selectivities to thermal methods make photochemistry an especially powerful tool for the synthesis of complex target molecules. In this Review, we highlight recent examples of total syntheses (from 2020 to 2025) featuring photochemical reactions as pivotal steps. Although the application of photochemistry in total synthesis has been consistently reviewed throughout the past decades, we feel that the wider emergence of photocatalytic methods, together with the continued importance of certain direct irradiation approaches, warrants its own discussion. We hope that our analytical approach and strategic insights will help us to identify cases where photochemical reactions could prove useful, thereby further encouraging their use in total syntheses.

• Publication year

  2025

• Venue

  Journal of Natural Products

• Publication date

  2025-11-06

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1021/acs.jnatprod.5c00874PMID 41195820PMCID 12670513
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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