The N-Terminal Region of HIV-1 Tat Protein Binds CD127 in Human CD8 T Cells to Target the Receptor for Down Regulation Through Tat's Basic Region.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Current HIV Research

• Publication date

  2015-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2174/1570162X1303150506184606PMID 25986373
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup

  2015cited by this paper
• IL-7 Receptor Recovery on CD8 T-Cells Isolated from HIV+ Patients Is Inhibited by the HIV Tat Protein

  2014cited by this paper
• HIV-1 Tat affects the programming and functionality of human CD8+ T cells by modulating the expression of T-box transcription factors

  2014cited by this paper
• The HIV-1 Tat Protein Induces the Activation of CD8+ T Cells and Affects In Vivo the Magnitude and Kinetics of Antiviral Responses

  2013cited by this paper
• IL‐7 downregulates IL‐7Rα expression in human CD8 T cells by two independent mechanisms

  2013cited by this paper
• The Ins and Outs of HIV‐1 Tat

  2012cited by this paper
• Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control

  2011cited by this paper
• Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection

  2011cited by this paper
• The Gut Mucosal Viral Reservoir in HIV-Infected Patients Is Not the Major Source of Rebound Plasma Viremia following Interruption of Highly Active Antiretroviral Therapy

  2011cited by this paper
• Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques

  2011cited by this paper
• The Class III Kinase Vps34 Promotes T Lymphocyte Survival through Regulating IL-7Rα Surface Expression

  2011cited by this paper
• Soluble HIV Tat Protein Removes the IL-7 Receptor α-Chain from the Surface of Resting CD8 T Cells and Targets It for Degradation

  2010cited by this paper
• Therapeutic Immunization with HIV-1 Tat Reduces Immune Activation and Loss of Regulatory T-Cells and Improves Immune Function in Subjects on HAART

  2010cited by this paper
• Effect of the redox state on HIV-1 tat protein multimerization and cell internalization and trafficking

  2010cited by this paper
• c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner

  2010cited by this paper
• Phosphatidylinositol‐(4,5)‐bisphosphate enables efficient secretion of HIV‐1 Tat by infected T‐cells

  2010cited by this paper
• HIV‐1 Tat is unconventionally secreted through the plasma membrane

  2010cited by this paper
• One lipid, multiple functions: how various pools of PI(4,5)P2 are created in the plasma membrane

  2010cited by this paper
• Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality

  2010cited by this paper
• HIV-1 transactivator protein induction of suppressor of cytokine signaling-2 contributes to dysregulation of IFN{gamma} signaling.

  2009cited by this paper
• IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells.

  2009cited by this paper
• Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primates.

  2009cited by this paper
• The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

  2009cited by this paper
• Mechanism for HIV-1 Tat Insertion into the Endosome Membrane*

  2009cited by this paper
• Parallel conduction of the phase I preventive and therapeutic trials based on the Tat vaccine candidate.

  2009cited by this paper
• Differential Regulation of Human IL-7 Receptor α Expression by IL-7 and TCR Signaling1

  2008cited by this paper
• HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

  2008cited by this paper
• HIV-1 Tat protein induces TNF-alpha and IL-10 production by human macrophages: differential implication of PKC-betaII and -delta isozymes and MAP kinases ERK1/2 and p38.

  2008cited by this paper
• Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy

  2008cited by this paper
• HIV-1 Tat Mediates Degradation of RON Receptor Tyrosine Kinase, a Regulator of Inflammation1

  2008cited by this paper
• Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.

  2008cited by this paper
• Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy.

  2008cited by this paper
• IL-10 Regulation by HIV-Tat in Primary Human Monocytic Cells: Involvement of Calmodulin/Calmodulin-Dependent Protein Kinase-Activated p38 MAPK and Sp-1 and CREB-1 Transcription Factors1

  2007cited by this paper
• Rate of Increase in Circulating IL-7 and Loss of IL-7Rα Expression Differ in HIV-1 and HIV-2 Infections: Two Lymphopenic Diseases with Similar Hyperimmune Activation but Distinct Outcomes1

  2007cited by this paper
• Interleukin-7 Receptor Expression on CD8 T-Cells Is Downregulated by the HIV Tat Protein

  2006cited by this paper
• The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostasis and the challenges facing its utilization as a novel therapy.

  2006cited by this paper
• CD127 expression and regulation are altered in the memory CD8 T cells of HIV‐infected patients − reversal by highly active anti‐retroviral therapy (HAART)

  2006cited by this paper
• HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1

  2006cited by this paper
• IL‐7Rα expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation

  2006cited by this paper
• HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells.

  2006cited by this paper
• Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription

  2006cited by this paper
• Loss of CD127 Expression Defines an Expansion of Effector CD8+ T Cells in HIV-Infected Individuals1

  2005cited by this paper
• Decoding Tat: the biology of HIV Tat posttranslational modifications.

  2005cited by this paper
• Modulation of interleukin-7 receptor expression characterizes differentiation of CD8 T cells specific for HIV, EBV and CMV

  2005cited by this paper
• Loss of IL-7Rα is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients

  2005cited by this paper
• The presence of anti-Tat antibodies is predictive of long-term nonprogression to AIDS or severe immunodeficiency: findings in a cohort of HIV-1 seroconverters.

  2005cited by this paper
• HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells.

  2005cited by this paper
• HIV‐1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses

  2005cited by this paper
• HIV-1 Tat protein enhances Microtubule polymerization

  2005cited by this paper
• Transcellular protein transduction using the Tat protein of HIV-1.

  2005cited by this paper
• HIV-1 Tat Protein Modulates the Generation of Cytotoxic T Cell Epitopes by Modifying Proteasome Composition and Enzymatic Activity1

  2004cited by this paper
• Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat.

  2004cited by this paper
• Multiple effects of HIV‐1 trans‐activator protein on the pathogenesis of HIV‐1 infection

  2004cited by this paper
• HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses.

  2004cited by this paper
• Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

  2003cited by this paper
• Cellular uptake [correction of utake] of the Tat peptide: an endocytosis mechanism following ionic interactions.

  2003cited by this paper
• Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic.

  2003cited by this paper
• A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

  2003cited by this paper
• The RTP site shared by the HIV-1 Tat protein and the 11S regulator subunit alpha is crucial for their effects on proteasome function including antigen processing.

  2002cited by this paper
• Interleukin-7: from bench to clinic.

  2002cited by this paper
• HIV‐1 Tat targets microtubules to induce apoptosis, a process promoted by the pro‐apoptotic Bcl‐2 relative Bim

  2002cited by this paper
• The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection

  2002cited by this paper
• Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma.

  2001cited by this paper
• Cellular Immune Responses and Viral Diversity in Individuals Treated during Acute and Early HIV-1 Infection

  2001cited by this paper
• Antibodies against full-length Tat protein and some low-molecular-weight Tat-peptides correlate with low or undetectable viral load in HIV-1 seropositive patients.

  2001cited by this paper
• Internalization of HIV-1 Tat Requires Cell Surface Heparan Sulfate Proteoglycans*

  2001cited by this paper
• Interleukin-7 receptor expression on CD8(+) T cells is reduced in HIV infection and partially restored with effective antiretroviral therapy.

  2001cited by this paper
• Inhibition of CXCR4-dependent HIV-1 infection by extracellular HIV-1 Tat.

  2000cited by this paper
• Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands

  2000cited by this paper
• HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

  2000cited by this paper
• Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1.

  2000cited by this paper
• HIV‐1 Tat transcriptional activity is regulated by acetylation

  1999cited by this paper
• The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

  1999cited by this paper
• Immune reconstitution in HIV infection.

  1999cited by this paper
• Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge.

  1999cited by this paper
• IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire.

  1998cited by this paper
• HIV‐1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix‐associated heparan sulfate proteoglycans through its basic region

  1997cited by this paper
• HIV-1 Tat Inhibits the 20 S Proteasome and Its 11 S Regulator-mediated Activation*

  1997cited by this paper
• The Tat Protein of Human Immunodeficiency Virus Type 1 Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR*

  1997cited by this paper
• Human immunodeficiency virus type 1 Tat protein induces death by apoptosis in primary human neuron cultures.

  1997cited by this paper
• Human immunodeficiency virus type 1 Rev- and Tat-specific cytotoxic T lymphocyte frequencies inversely correlate with rapid progression to AIDS.

  1997cited by this paper
• A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus*

  1997cited by this paper
• HIV-1 Tat protein is able to efficiently transactivate the HIV-2 LTR through a TAR RNA element lacking both dinucleotide bulge binding sites.

  1995cited by this paper
• Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.

  1995cited by this paper
• Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

  1995cited by this paper
• Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

  1994cited by this paper
• Intracellular analysis of in vitro modified HIV Tat protein.

  1994cited by this paper
• Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

  1994cited by this paper
• Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

  1994cited by this paper
• Human immunodeficiency virus 1 Tat binds to dipeptidyl aminopeptidase IV (CD26): a possible mechanism for Tat's immunosuppressive activity.

  1994cited by this paper
• The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.

  1993cited by this paper
• Transcellular transactivation by the human immunodeficiency virus type 1 tat protein

  1991cited by this paper
• IL-7 regulation of cytotoxic lymphocytes: pore-forming protein gene expression, interferon-gamma production, and cytotoxicity of human peripheral blood lymphocytes subsets.

  1991cited by this paper
• Selective Stimulation of CD4+ Versus CD8+ T-Cell Subsets in Symptomatic and Asymptomatic HIV-1-Infected Individuals

  1991cited by this paper
• Functional substitution of the basic domain of the HIV-1 trans-activator, Tat, with the basic domain of the functionally heterologous Rev.

  1990cited by this paper
• Identification of an Arg-Gly-Asp (RGD) cell adhesion site in human immunodeficiency virus type 1 transactivation protein, tat

  1990cited by this paper
• Regulation of human T cell proliferation by IL-7.

  1990cited by this paper
• Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

  1990cited by this paper
• Structural and functional characterization of human immunodeficiency virus tat protein

  1989cited by this paper
• Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein

  1989cited by this paper

• Tat basic domain: A “Swiss army knife” of HIV‐1 Tat?

  2019cites this paper
• HIV-1 tat protein recruits CIS to the cytoplasmic tail of CD127 to induce receptor ubiquitination and proteasomal degradation.

  2016cites this paper