The light subunit of system bo,+ is fully functional in the absence of the heavy subunit

No abstract is available for this paper.

• Publication year

  2002

• Venue

  EMBO Journal

• Publication date

  2002-09-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/emboj/cdf500PMID 12234930PMCID PMC126296
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of system L heterodimeric amino acid exchangers by intracellular substrates

  2002cited by this paper
• rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney.

  2002cited by this paper
• Fluorescence Resonance Energy Transfer Studies on the Interaction between the Lactate Transporter MCT1 and CD147 Provide Information on the Topology and Stoichiometry of the Complex in Situ *

  2002cited by this paper
• Human cystinuria-related transporter: localization and functional characterization.

  2001cited by this paper
• Heteromeric amino acid transporters: biochemistry, genetics, and physiology.

  2001cited by this paper
• Sequential Amino Acid Exchange across b0,+-like System in Chicken Brush Border Jejunum

  2001cited by this paper
• The functional role of beta subunits in oligomeric P-type ATPases.

  2001cited by this paper
• Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc–

  2001cited by this paper
• Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation

  2001cited by this paper
• The Metabolic and Molecular Bases of Inherited Disease

  2001cited by this paper
• Function and structure of heterodimeric amino acid transporters.

  2001cited by this paper
• The molecular bases of cystinuria and lysinuric protein intolerance.

  2001cited by this paper
• Functional analysis of mutations in SLC7A9, and genotype-phenotype correlation in non-Type I cystinuria.

  2001cited by this paper
• Surface Antigen CD98(4F2): Not a Single Membrane Protein, But a Family of Proteins with Multiple Functions

  2000cited by this paper
• Identification and functional characterization of a Na[+]-independent neutral amino acid transporter with broad substrate selectivity

  2000cited by this paper
• Functional analysis of novel mutations in y(+)LAT-1 amino acid transporter gene causing lysinuric protein intolerance (LPI).

  2000cited by this paper
• Transport Properties of a System y+L Neutral and Basic Amino Acid Transporter

  2000cited by this paper
• Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity.

  2000cited by this paper
• CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

  2000cited by this paper
• Glycoprotein-associated amino acid exchangers: broadening the range of transport specificity

  2000cited by this paper
• Molecular Cloning and Expression of Human xCT, the Light Chain of Amino Acid Transport System xc¯

  2000cited by this paper
• Identification and Characterization of a Na+-independent Neutral Amino Acid Transporter That Associates with the 4F2 Heavy Chain and Exhibits Substrate Selectivity for Small Neutral d- and l-Amino Acids*

  2000cited by this paper
• Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT

  1999cited by this paper
• Amino acid transport of y+L‐type by heterodimers of 4F2hc/CD98 and members of the glycoprotein‐associated amino acid transporter family

  1999cited by this paper
• Luminal heterodimeric amino acid transporter defective in cystinuria.

  1999cited by this paper
• New Glycoprotein-Associated Amino Acid Transporters

  1999cited by this paper
• Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins*

  1999cited by this paper
• Identification of an Amino Acid Transporter Associated with the Cystinuria-related Type II Membrane Glycoprotein*

  1999cited by this paper
• Identification of a Membrane Protein, LAT-2, That Co-expresses with 4F2 Heavy Chain, an L-type Amino Acid Transport Activity with Broad Specificity for Small and Large Zwitterionic Amino Acids*

  1999cited by this paper
• LAT2, a New Basolateral 4F2hc/CD98-associated Amino Acid Transporter of Kidney and Intestine*

  1999cited by this paper
• Identification and Functional Characterization of a Na+-independent Neutral Amino Acid Transporter with Broad Substrate Selectivity*

  1999cited by this paper
• Identification and Characterization of a Membrane Protein (y+L Amino Acid Transporter-1) That Associates with 4F2hc to Encode the Amino Acid Transport Activity y+L

  1998cited by this paper
• Membrane transport of long-chain fatty acids: evidence for a facilitated process.

  1998cited by this paper
• Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

  1998cited by this paper
• Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)*

  1998cited by this paper
• An Intracellular Trafficking Defect in Type I Cystinuria rBAT Mutants M467T and M467K*

  1997cited by this paper
• Obligatory Amino Acid Exchange via Systems bo,+-like and y+L-like

  1996cited by this paper
• rBAT is an Amino Acid Exchanger with Variable Stoichiometry

  1996cited by this paper
• Oligomeric structure of a renal cystine transporter: implications in cystinuria

  1995cited by this paper
• Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine

  1994cited by this paper
• Opposite directed currents induced by the transport of dibasic and neutral amino acids in Xenopus oocytes expressing the protein rBAT.

  1994cited by this paper
• Altered band 3 structure and function in glycophorin A- and B-deficient (MkMk) red blood cells.

  1994cited by this paper
• Electrogenic amino acid exchange via the rBAT transporter

  1994cited by this paper
• Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids.

  1992cited by this paper
• Cloning and expression of a rat brain L-glutamate transporter

  1992cited by this paper
• The renal handling of amino acids and oligopeptides.

  1988cited by this paper
• Reconstitution and purification of the sodium- and chloride-coupled gamma-aminobutyric acid transporter from rat brain.

  1985cited by this paper
• Renal handling of amino acids and oligopeptides.

  1981cited by this paper
• A rapid method for the isolation of kidney brush border membranes.

  1979cited by this paper
• Partial Resolution of the Enzymes Catalyzing Oxidative Phosphorylation XXV. RECONSTITUTION OF VESICLES CATALYZING 32Pi—ADENOSINE TRIPHOSPHATE EXCHANGE

  1971cited by this paper
• Partial resolution of the enzymes catalyzing oxidative phosphorylation. X. Correlation of morphology and function in submitochondrial particles.

  1966cited by this paper
• Inulin and endogenous amino acid renal clearances in cystinuria: evidence for tubular secretion.

  1962cited by this paper
• A simple method for the isolation and purification of total lipides from animal tissues.

  1957cited by this paper

• Efficient kidney gene transfer and proximal tubule transduction using self-complementary AAV.cc47 vectors

  2025cites this paper
• Mechanisms involved in aminoacidurias: impacts of genetic and environmental factors

  2025cites this paper
• Role of Transport Proteins for the Renal Handling of L-Arginine and Related Derivatives

  2025cites this paper
• Cystinuria: A Genetic and Molecular View – What Is Known about Animal Models and Cells

  2025cites this paper
• Prevalence and characteristics of genetic disease in adult kidney stone formers

  2024cites this paper
• Intestinal Amino Acid Transport and Metabolic Health.

  2023cites this paper
• Interpretation of SLC3A1 and SLC7A9 variants in cystinuria patients: The significance of the PM3 criterion and protein stability

  2023cites this paper
• Prevalence and characteristics of monogenic disease in adult kidney stone formers

  2023cites this paper
• Amino acid profiles, amino acid sensors and transporters expression and intestinal microbiota are differentially altered in goats infected with Haemonchus contortus

  2023cites this paper
• Characterization of substrates and inhibitors of the human heterodimeric transporter 4F2hc-LAT1 using purified protein and the scintillation proximity radioligand binding assay

  2023cites this paper
• Absorption of methionine sources in animals—is there more to know?

  2022cites this paper
• HATs meet structural biology.

  2022cites this paper
• Water salinity and postprandial effects on transcription of peptide and amino acid transporters in the kidney of Mozambique tilapia (Oreochromis mossambicus)

  2021cites this paper
• Heteromeric Amino Acid Transporters in Brain: from Physiology to Pathology

  2021cites this paper
• Pichia pastoris and the Recombinant Human Heterodimeric Amino Acid Transporter 4F2hc-LAT1: From Clone Selection to Pure Protein

  2021cites this paper
• The zebrafish cationic amino acid transporter/glycoprotein-associated family: sequence and spatiotemporal distribution during development of the transport system b0,+ (slc3a1/slc7a9)

  2021cites this paper
• Yeast Cell-Based Transport Assay for the Functional Characterization of Human 4F2hc-LAT1 and ‐LAT2, and LAT1 and LAT2 Substrates and Inhibitors

  2021cites this paper
• Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.

  2020cites this paper
• Facilitated Diffusion of Proline across Membranes of Liposomes and Living Cells by a Calix[4]pyrrole Cavitand

  2020cites this paper
• Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

  2020cites this paper
• Molecular cloning of the amino acid transporter b 0,+ AT cDNA from the orange‐spotted grouper ( Epinephelus coioides ) and the effect of arginine on its expression

  2020cites this paper
• Asc-1 Transporter (SLC7A10): Homology Models And Molecular Dynamics Insights Into The First Steps Of The Transport Mechanism

  2020cites this paper
• Transport of L-Arginine Related Cardiovascular Risk Markers

  2020cites this paper
• Cryo-EM structure of the human heteromeric amino acid transporter b0,+AT-rBAT

  2020cites this paper
• In silico characterization of residues essential for substrate binding of human cystine transporter, xCT

  2019cites this paper
• CD98hc (SLC3A2) sustains amino acid and nucleotide availability for cell cycle progression

  2019cites this paper
• Functional characterization of the alanine-serine-cysteine exchanger of Carnobacterium sp AT7

  2019cites this paper
• The diagnosis, genetics and management of patients with cystinuria

  2018cites this paper
• Atomic-level characterization of conformational transition and substrate binding of xCT transporter

  2018cites this paper
• Pathophysiology of immune-related complications in lysinuric protein intolerance

  2018cites this paper
• In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria

  2018cites this paper
• Amino Acid Transport Across the Mammalian Intestine.

  2018cites this paper
• Essential Roles of L-Type Amino Acid Transporter 1 in Syncytiotrophoblast Development by Presenting Fusogenic 4F2hc

  2017cites this paper
• Differential expression of amino-acid transporters along the intestine of Mozambique tilapia (Oreochromis mossambicus) and the effect of water salinity and time after feeding

  2017cites this paper
• Clinical and molecular characterization of cystinuria in a French cohort: relevance of assessing large‐scale rearrangements and splicing variants

  2017cites this paper
• The interaction between lysyl-lysine and arginine in the neonatal Yucatan miniature pig small intestine

  2017cites this paper
• Remarkable evolutionary relatedness among the enzymes and proteins from the α-amylase family

  2016cites this paper
• Gastrointestinal methionine shuttle: Priority handling of precious goods

  2016cites this paper
• Heteromeric amino acid transporters. In search of the molecular bases of transport cycle mechanisms.

  2016cites this paper
• 4F2hc/LAT1 heterodimer: a promising candidate for solving the first atomic structure of a heteromeric amino acid transporter = Heterodímero 4F2hc/LAT1: un candidato prometedor para resolver la primera estructura atómica de un transportador heteromérico de aminoácidos

  2016influential citation
• A translational approach to investigate the role of membrane transport proteins in the renal stone disease, cystinuria

  2016cites this paper
• Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability*

  2016cites this paper
• The role of N-glycans and the C-terminal loop of the subunit rBAT in the biogenesis of the cystinuria-associated transporter.

  2016cites this paper
• LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter.

  2015cites this paper
• Expression of genes coding for selected amino acid transporters in small intestine, liver, and skeletal muscle of pigs fed excess branched-chain amino acids.

  2015cites this paper
• The effects of mutated cationic amino acid transporter y+LAT1 at the cellular and systemic level

  2015cites this paper
• Aminoaciduria and Glycosuria in Children

  2015cites this paper
• Detergent-Induced Stabilization and Improved 3D Map of the Human Heteromeric Amino Acid Transporter 4F2hc-LAT2

  2014cites this paper
• Transport of amino acids in the kidney.

  2014cites this paper
• Role of LAT1 in the promotion of amino acid incorporation in activated T cells.

  2014cites this paper
• Structural bases for the interaction and stabilization of the human amino acid transporter LAT2 with its ancillary protein 4F2hc

  2014cites this paper
• Fluorescence-based imaging of cellular defect in lysinuric protein intolerance (LPI)

  2013cites this paper
• Expression of human heteromeric amino acid transporters in the yeast Pichia pastoris.

  2013cites this paper
• Dipeptide transport in Yucatan miniature piglet intestine

  2013cites this paper
• The SLC 3 and SLC 7 families of amino acid transporters q

  2013influential citation
• The SLC3 and SLC7 families of amino acid transporters.

  2013cites this paper
• Folding of Its Helper Subunit Transporter Is Required for Oxidative Carrier Subunit of Plasma Membrane Membrane Biology

  2013cites this paper
• Kidney transport of amino acids and oligopeptides, and aminoacidurias

  2013cites this paper
• Ontogenic expression of the amino acid transporter b(0,+)AT in suckling Huanjiang piglets: effect of intra-uterine growth restriction.

  2013cites this paper
• A random approach to stabilize a membrane transport protein for crystallization studies / Un enfoque aleatorio para estabilizar un transportador de membrana para estudios de cristalización

  2013cites this paper
• Inherited Disorders of the Renal Tubule

  2012cites this paper
• System xc‐ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

  2012cites this paper
• Carrier Subunit of Plasma Membrane Transporter Is Required for Oxidative Folding of Its Helper Subunit*

  2012cites this paper
• Amino acid secondary transporters: toward a common transport mechanism.

  2012cites this paper
• A Chimera Carrying the Functional Domain of the Orphan Protein SLC7A14 in the Backbone of SLC7A2 Mediates Trans-stimulated Arginine Transport*

  2012cites this paper
• Renal Handling of Organic Solutes

  2011cites this paper
• The role of amino acid transporters in inherited and acquired diseases.

  2011cites this paper
• Amino acid homeostasis in Caenorhabditis elegans lacking the intestinal peptide transporter PEPT-1 and identification of PEPT-1 modulator proteins

  2011cites this paper
• ROLE OF 4 F 2 HC IN TUMORIGENESIS

  2010cites this paper
• Pathophysiology and treatment of cystinuria

  2010cites this paper
• Role of Transmembrane Domain 8 in Substrate Selectivity and Translocation of SteT, a Member of the l-Amino Acid Transporter (LAT) Family*

  2010cites this paper
• Cystinuria and Cystine Stones

  2010cites this paper
• Molecular cloning, tissue distribution and ontogenetic expression of the amino acid transporter b(0,+) cDNA in the small intestine of Tibetan suckling piglets.

  2009cites this paper
• Pathophysiology and management of cystine stones

  2009cites this paper
• Primary Inherited Aminoacidurias: Genetic Defects in the Renal Handling of Amino Acids

  2009cites this paper
• Looking for the ancestry of the heavy‐chain subunits of heteromeric amino acid transporters rBAT and 4F2hc within the GH13 α‐amylase family

  2009cites this paper
• Aminoaciduria and Glycosuria

  2009cites this paper
• A novel role of the C-terminus of b 0,+ AT in the ER-Golgi trafficking of the rBAT-b 0,+ AT heterodimeric amino acid transporter.

  2009cites this paper
• Aminoacidurias: Clinical and molecular aspects.

  2008cites this paper
• ATGCTA ATGGAA TTGCTC CCACCGGAGGAA LL 8 CTAATGGAAGTG CTCCTA CCGGAGGAAGAC LL 9 ATGGAAGTGGTC CTACTG GAGGAAGACCCT LL 10 GAAGTGGTCCCA CTGCTG GAAGACCCTTAA LL 11 GTGGTCCCACCG CTGTTA GACCCTTAACAA AA 6 CTTCAGATGCTA GCGGCA GTGGTCCCACCG AA 7 ATGCTA ATGGAA GCGGCC CCACCGGAGGAA AA 8 CTAATGGAAGTG GCGGCA CCGGAGGAAG

  2008cites this paper
• CHAPTER 72 – Amino Acids, Oligopeptides, and Hyperaminoacidurias

  2008cites this paper
• Amino acid transport across mammalian intestinal and renal epithelia.

  2008cites this paper
• Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2.

  2008cites this paper
• Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype.

  2008cites this paper
• Functional and Structural Characterization of the First Prokaryotic Member of the L-Amino Acid Transporter (LAT) Family

  2007cites this paper
• Slc7a9 knockout mouse is a good cystinuria model for antilithiasic pharmacological studies.

  2007cites this paper
• Molecular genetic studies on cystinuria

  2007cites this paper
• Mechanisms for Cadmium Lumen-to-Cell Transport by the Luminal Membrane of the Rabbit Proximal Tubule

  2007cites this paper
• Estructura tridimensional del domini extracel·lular de 4F2hc (CD98) humà

  2006cites this paper
• The Structural and Functional Units of Heteromeric Amino Acid Transporters

  2006cites this paper
• Mutation of the 4F2 heavy-chain carboxy terminus causes y+LAT2 light-chain dysfunction

  2006influential citation
• Untersuchungen zur Pathophysiologie der Cystinurie Typ A: Elektrophysiologische Charakterisierung des hrBAT Wildtyps und der Mutation T216M in Xenopus Oozyten

  2006cites this paper
• The genetics of heteromeric amino acid transporters.

  2005cites this paper
• Distribution and Relative Abundance of Nutrient Transporter mRNA in the Gastrointestinal Tract of Black Bears

  2005cites this paper
• Developmental Regulation of the Expression of Nutrient Transporter and BrushBorder Membrane Hydrolase Genes in the Small Intestine of Piglets

  2005cites this paper
• Multiple pathways for cationic amino acid transport in rat thyroid epithelial cell line PC Cl3.

  2005cites this paper
• Identification and Functional Characterization of a Novel Low Affinity Aromatic-preferring Amino Acid Transporter (arpAT)

  2005cites this paper
• Transportadores heterométricos de aminoácidos: análisis mutacional de rBAT en cistinuria y estudios de relación estructura-función

  2005influential citation
• Reabsorció renal d'aminoàcids: anàlisi de mutacions de SLC7A9, el gen de cistinúria de tipus B, i generació d'un model murí "knockout" de Slc7a8

  2005cites this paper
• Heterodimeric amino acid transporter glycoprotein domains determining functional subunit association.

  2005cites this paper