Protein Kinase C Regulates Meiosis in Mammalian Oocytes

The protein kinase C (PKC) family comprises enzyme kinases that regulate cell survival, metabolism, and proliferation. PKC isotypes (PKCs) phosphorylate specific downstream substrates, thereby controlling critical steps in both mitotic and meiotic cell division. Throughout the cell cycle, PKCs orchestrate essential processes, such as chromosome segregation, recombination, and cell cycle progression. In vertebrates, PKCs play essential roles in oogenesis and the early stages of embryo development. Disruption of PKC signaling in mammalian oocytes can lead to errors in chromosome segregation and induce meiotic arrest. Therefore, investigating PKC function in meiosis is crucial for advancing fundamental biological research and for developing new approaches to infertility treatment.

• Publication year

  2025

• Venue

  Bioessays

• Publication date

  2025-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/bies.70087PMID 41208434PMCID 12822854
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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