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Mechanisms of lncRNA in Diabetic Foot Ulcer Wound Healing

Yiming Chen,Mengting Wang,Xiaoliang Cao,Shengfeng Gao,Yasu Jiang,Zhenhua Gong

Published 2025 in Journal of Gene Medicine

ABSTRACT

Diabetes mellitus (DM) is a chronic metabolic disease, and some diabetic patients develop diabetic foot ulcers (DFU), which are one of the most prevalent and serious complications among diabetic patients. These ulcers can lead to neuropathy, vasculopathy and severe infections. LncRNAs, a class of long‐stranded noncoding RNAs that regulate gene expression, have been shown to play a critical regulatory role in diabetic foot ulcer wound healing. These molecules have been demonstrated to modulate numerous facets of the inflammatory response, cell proliferation and angiogenesis, which collectively influence the outcome of wound healing. A substantial body of research has emerged in recent years, highlighting the critical role of these noncoding transcripts in DFU. This paper reviews recent research advances on the regulatory functions and potential mechanisms of noncoding transcripts in the healing of diabetic foot ulcers, based on a literature search of databases such as PubMed and Web of Science over the past decade.

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