Iterative plug-and-play methodology for constructing and modifying synthetic gene networks

We present a methodology for the design, construction and modification of synthetic gene networks. This method emphasizes post-assembly modification of constructs based on network behavior, thus facilitating iterative design strategies and rapid tuning and repurposing of gene networks. The ease of post-construction modification afforded by this approach and the ever-increasing repository of components within the framework will help accelerate the development of functional genetic circuits for synthetic biology.

• Publication year

  2012

• Venue

  Nature Methods

• Publication date

  2012-09-17

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1038/nmeth.2205PMID 23042452PMCID 3492501
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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