A 360-degree overview of paediatric NAFLD: recent insights.

Non-alcoholic fatty liver disease (NAFLD) is a multi-faceted disorder, which ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) with/without fibrosis. The effects of specific risk factors, such as obesity and sedentary lifestyle, on predisposing genetic settings eventually lead to the development of NAFLD in children. The complex interplay between genes and environment in NAFLD pathogenesis is sustained by multiple mechanisms that involve liver crosstalk with other organs and tissues, especially gut and adipose tissue. Unfortunately, natural history of paediatric NAFLD is lacking, and the etiopathogenesis is still in the process of being defined. Potential early predictors and suitable non-invasive diagnostic tools can be discovered based on the pathogenetic mechanisms and histological patterns. This will also help design novel treatments and a comprehensive and successful management strategy for patients. In this review, we discuss the recent advances made in genetics, etiopathogenesis, diagnosis, and therapeutic management of NAFLD, focusing especially on the obesity-related steatotic liver condition.

• Publication year

  2013

• Venue

  Journal of Hepatology

• Publication date

  2013-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.jhep.2012.12.003PMID 23238106
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• Recent advances are reviewed across genetics, etiopathogenesis, diagnosis, and therapeutic management, with special focus on the obesity-related steatotic liver condition.

  Confidence 0.93

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• Early predictors and non-invasive diagnostic tools are highlighted as priorities for identifying pathogenetic mechanisms and histological patterns in paediatric NAFLD.

  Confidence 0.92

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• Gene-environment interplay, including crosstalk between the liver, gut, and adipose tissue, is emphasized as central to paediatric NAFLD pathogenesis.

  Confidence 0.95

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• Paediatric NAFLD is presented as a heterogeneous disease spanning simple steatosis through non-alcoholic steatohepatitis with or without fibrosis.

  Confidence 0.97

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review

• early predictors

  biomarker

  Potential markers or features that could identify disease presence or progression at an early stage.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• gene-environment interplay

  mechanism

  The combined influence of inherited susceptibility and environmental exposures discussed as a driver of disease development.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• genetics

  field

  Inherited factors and risk variants relevant to susceptibility and disease expression in paediatric NAFLD.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• gut and adipose tissue crosstalk

  mechanism

  Inter-organ signaling between the liver, gut, and adipose tissue that is described as part of disease pathogenesis.

  Aliases: liver crosstalk with gut and adipose tissue

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• non-alcoholic steatohepatitis

  disease subtype

  The inflammatory and more severe disease subtype of fatty liver disease referenced as part of the NAFLD spectrum.

  Aliases: NASH

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• non-invasive diagnostic tools

  diagnostic method

  Diagnostic approaches that assess disease without liver biopsy and are discussed as candidates for earlier detection.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• obesity-related steatotic liver condition

  condition

  The obesity-associated form of fatty liver disease that is the main focus of the review.

  Aliases: obesity-related NAFLD

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• paediatric nafld

  condition

  Non-alcoholic fatty liver disease in children, covering the disease spectrum discussed in the review.

  Aliases: NAFLD

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review
• therapeutic management

  clinical management

  Treatment and care strategies considered in the review for managing paediatric NAFLD.

  박진우 (dztg5apj7m) extraction뀨 (7c402c1b98) reviewKiller Whale (322360f1c1) reviewq (76h6bfydm6) review

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