Wearable Sensing for Clinical Physiology Monitoring: Emerging Paradigms.

Advances in wearable sensing technology are driving a new era of personalized health monitoring. In contrast to the hard, rigid form factors of conventional wearable sensors, these emerging skin-interfaced systems support high-quality physiological measurements across biophysical, biochemical, and kinematic signals of interest. These platforms enable continuous monitoring of complex physiological processes with unprecedented detail as a result of a seamless, conformal skin-interface and advanced wireless communications capabilities. These platforms integrate flexible materials, miniaturized electronics, and wireless communication to provide detailed physiological data during daily activities. This review examines how skin-interfaced wearables are advancing patient care, remote monitoring, and large-scale health studies. We highlight critical barriers to clinical adoption including interpreting data, validating devices, and integration into healthcare systems. Key opportunities include sustainable manufacturing, point-of-care fabrication, and development of disease-specific digital biomarkers. By addressing these challenges through collaboration among engineers, clinicians, and data scientists, wearable sensors can expand patient access to advanced physiological monitoring and transform personalized medicine.

• Publication year

  2025

• Venue

  Physiology

• Publication date

  2025-11-10

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1152/physiol.00039.2024PMID 41213179PMCID PMC12805256
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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