Subsecond dopamine fluctuations do not specify the vigor of ongoing actions

Dopamine (DA) is essential for the production of vigorous actions, but how DA modifies the gain of motor commands remains unclear. Here we show that subsecond DA transients in the striatum of mice are neither required nor sufficient for specifying the vigor of ongoing forelimb movements. Our findings have important implications for our understanding of how DA contributes to motor control under physiological conditions and in Parkinson’s disease. Liu and colleagues show that the vigor (that is, speed and amplitude) of dexterous movements is not controlled by ongoing fluctuations in extracellular dopamine within the dorsal striatum of mice.

• Publication year

  2025

• Venue

  Nature Neuroscience

• Publication date

  2025-11-10

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41593-025-02102-1PMID 41214177PMCID 12672363
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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