The role of neuroplasticity in dopaminergic therapy for Parkinson disease

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Nature Reviews Neurology

• Publication date

  2013-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/nrneurol.2013.57PMID 23588357
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Non-homogeneous effect of levodopa on inhibitory circuits in Parkinson's disease and dyskinesia.

  2013cited by this paper
• Early, severe and bilateral loss of LTP and LTD-like plasticity in motor cortex (M1) in de novo Parkinson's disease.

  2012cited by this paper
• Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.

  2012cited by this paper
• Overcoming Motor “Forgetting” Through Reinforcement Of Learned Actions

  2012cited by this paper
• Functional consequences of mutations in postsynaptic scaffolding proteins and relevance to psychiatric disorders.

  2012cited by this paper
• Effects of theta burst stimulation on motor cortex excitability in Parkinson's disease.

  2012cited by this paper
• Tardive dyskinesia is caused by maladaptive synaptic plasticity: A hypothesis

  2012cited by this paper
• Functional reorganization of sensorimotor cortex in early Parkinson disease

  2012cited by this paper
• A role for dopamine-mediated learning in the pathophysiology and treatment of Parkinson's disease.

  2012cited by this paper
• Activity enhances dopaminergic long-duration response in Parkinson disease

  2012cited by this paper
• Striatal plasticity in Parkinson's disease and L-dopa induced dyskinesia.

  2012cited by this paper
• Cerebellar regions involved in adaptation to force field and visuomotor perturbation.

  2012cited by this paper
• Lack of LTP-like plasticity in primary motor cortex in Parkinson's disease.

  2011cited by this paper
• Reviews

  2011cited by this paper
• Abnormal bidirectional plasticity-like effects in Parkinson's disease.

  2011cited by this paper
• Dopamine-Dependent Long-Term Depression Is Expressed in Striatal Spiny Neurons of Both Direct and Indirect Pathways: Implications for Parkinson's Disease

  2011cited by this paper
• Are we ready for a natural history of motor learning?

  2011cited by this paper
• Parkinson's disease differentially affects adaptation to gradual as compared to sudden visuomotor distortions.

  2011cited by this paper
• Aberrant striatal plasticity is specifically associated with dyskinesia following levodopa treatment

  2010cited by this paper
• The role of the long-duration response to levodopa in Parkinson’s disease

  2010cited by this paper
• Error correction, sensory prediction, and adaptation in motor control.

  2010cited by this paper
• A Double-Blind, Delayed-Start Trial of Rasagiline In Parkinson's Disease

  2010cited by this paper
• Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

  2010cited by this paper
• Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum.

  2010cited by this paper
• Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson’s disease

  2010cited by this paper
• Levodopa response in early Parkinson's disease

  2009cited by this paper
• A double-blind, delayed-start trial of rasagiline in Parkinson's disease.

  2009cited by this paper
• Dopamine‐dependent motor learning: Insight into levodopa's long‐duration response

  2009cited by this paper
• Parallel Explicit and Implicit Control of Reaching

  2009cited by this paper
• The serial reaction time task revisited: a study on motor sequence learning with an arm-reaching task

  2009cited by this paper
• Priming of rotational behavior by a dopamine receptor agonist in Hemiparkinsonian rats: movement-dependent induction.

  2009cited by this paper
• Contributions of the basal ganglia and functionally related brain structures to motor learning.

  2009cited by this paper
• Training Effects Outweigh Effects of Single-Session Conventional rTMS and Theta Burst Stimulation in PD Patients

  2009cited by this paper
• A neurocomputational account of catalepsy sensitization induced by D2 receptor blockade in rats: context dependency, extinction, and renewal

  2009cited by this paper
• Dopamine and synaptic plasticity in dorsal striatal circuits controlling action selection.

  2009cited by this paper
• Loss of Cocaine Locomotor Response in Pitx3-Deficient Mice Lacking a Nigrostriatal Pathway

  2009cited by this paper
• Update on models of basal ganglia function and dysfunction.

  2009cited by this paper
• Learning and consolidation of visuo-motor adaptation in Parkinson's disease.

  2009cited by this paper
• Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill

  2009cited by this paper
• Dopaminergic signals in primary motor cortex

  2009cited by this paper
• Dopamine Release in the Human Striatum: Motor and Cognitive Tasks Revisited

  2009cited by this paper
• Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

  2008cited by this paper
• Dopamine Receptor Activation Is Required for Corticostriatal Spike-Timing-Dependent Plasticity

  2008cited by this paper
• Motor sequence learning and movement disorders

  2008cited by this paper
• Pharmacokinetics and pharmacodynamics of levodopa

  2008cited by this paper
• Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson's disease models

  2007cited by this paper
• Transcranial magnetic stimulation as a method for investigating the plasticity of the brain in Parkinson's disease and dystonia.

  2007cited by this paper
• Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice

  2007cited by this paper
• D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons.

  2007cited by this paper
• Movement without dopamine: striatal dopamine is required to maintain but not to perform learned actions.

  2007cited by this paper
• Author ' s personal copy Striatal dopamine release in sequential learning

  2007cited by this paper
• Dopamine-mediated regulation of corticostriatal synaptic plasticity.

  2007cited by this paper
• Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum

  2006cited by this paper
• Cerebellar Contributions to Locomotor Adaptations during Splitbelt Treadmill Walking

  2006cited by this paper
• Timing of treatment initiation in Parkinson's disease: A need for reappraisal?

  2006cited by this paper
• Repetitive transcranial magnetic stimulation to improve mood and motor function in Parkinson's disease

  2006cited by this paper
• Longitudinal study of the motor response to levodopa in Parkinson's disease

  2006cited by this paper
• Altered plasticity of the human motor cortex in Parkinson's disease

  2006cited by this paper
• Practice Parameter: Treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology

  2006cited by this paper
• Motor cortex plasticity in Parkinson's disease and levodopa-induced dyskinesias.

  2006cited by this paper
• Dopaminergic drugs restore facilitatory premotor-motor interactions in Parkinson disease

  2005cited by this paper
• Non-invasive brain stimulation for Parkinson’s disease: a systematic review and meta-analysis of the literature

  2005cited by this paper
• Intact ability to learn internal models of arm dynamics in Huntington's disease but not cerebellar degeneration.

  2005cited by this paper
• Impaired acquisition of skilled behavior in rotarod task by moderate depletion of striatal dopamine in a pre-symptomatic stage model of Parkinson's disease.

  2005cited by this paper
• Motor fluctuations and dyskinesias in Parkinson's disease: Clinical manifestations

  2005cited by this paper
• 3,4-Dihydroxyphenylalanine Reverses the Motor Deficits in Pitx3-Deficient Aphakia Mice: Behavioral Characterization of a Novel Genetic Model of Parkinson's Disease

  2005cited by this paper
• The basal ganglia: learning new tricks and loving it.

  2005cited by this paper
• Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals.

  2004cited by this paper
• The mGluR theory of fragile X mental retardation.

  2004cited by this paper
• Levodopa and the progression of Parkinson's disease.

  2004cited by this paper
• Abnormal excitability of premotor-motor connections in de novo Parkinson's disease.

  2004cited by this paper
• Differential corticostriatal plasticity during fast and slow motor skill learning in mice.

  2004cited by this paper
• Loss of bidirectional striatal synaptic plasticity in L-DOPA–induced dyskinesia

  2003cited by this paper
• The effects of chronic L-DOPA therapy on pharmacodynamic parameters in a rat model of motor response fluctuations.

  2003cited by this paper
• Pathophysiology of Tourette's syndrome: striatal pathways revisited.

  2003cited by this paper
• Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons

  2003cited by this paper
• Presymptomatic compensation in Parkinson's disease is not dopamine-mediated.

  2003cited by this paper
• The primate basal ganglia: parallel and integrative networks.

  2003cited by this paper
• Pitx3 is required for development of substantia nigra dopaminergic neurons

  2003cited by this paper
• Distinct Roles of D1 and D5 Dopamine Receptors in Motor Activity and Striatal Synaptic Plasticity

  2003cited by this paper
• Quantitative description of loss of clinical benefit following withdrawal of levodopa–carbidopa and bromocriptine in early Parkinson's disease

  2002cited by this paper
• Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: Implications for the pathophysiology of cortical function

  2002cited by this paper
• Dopamine-dependent plasticity of corticostriatal synapses

  2002cited by this paper
• Early consolidation in human primary motor cortex

  2002cited by this paper
• Evolution of the response to levodopa during the first 4 years of therapy

  2002cited by this paper
• Frequency of levodopa‐related dyskinesias and motor fluctuations as estimated from the cumulative literature

  2001cited by this paper
• Facilitated glutamatergic transmission in the striatum of D2 dopamine receptor-deficient mice.

  2001cited by this paper
• Long‐duration effect and the postsynaptic compartment: Study using a dopamine agonist with a short half‐life

  2001cited by this paper
• Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens.

  2000cited by this paper
• D2 Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+ Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade

  2000cited by this paper
• The long-duration response to l-dopa in the treatment of early PD

  2000cited by this paper
• Association of coffee and caffeine intake with the risk of Parkinson disease.

  2000cited by this paper
• Human cerebellar activity reflecting an acquired internal model of a new tool

  2000cited by this paper
• The basal ganglia: a vertebrate solution to the selection problem?

  1999cited by this paper
• Loss of long-duration response to levodopa over time in PD

  1999cited by this paper
• Parallel neural networks for learning sequential procedures.

  1999cited by this paper
• The basal ganglia and chunking of action repertoires.

  1998cited by this paper
• The long-duration action of levodopa may be due to a postsynaptic effect.

  1997cited by this paper
• Long‐duration response to levodopa influences the pharmacodynamics of short‐duration response in Parkinson's disease

  1997cited by this paper
• A Neural Substrate of Prediction and Reward

  1997cited by this paper

• N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in Parkinson's disease models.

  2026cites this paper
• Subsecond dopamine fluctuations do not specify the vigor of ongoing actions

  2025cites this paper
• Association between gout, hyperuricaemia and Parkinson’s disease risk: a cohort study in western Sweden (2001–2017)

  2025cites this paper
• N-acetyl-l-leucine lowers pS129-synuclein and improves synaptic function in models of Parkinson’s disease

  2025cites this paper
• Levodopa treatment: impacts and mechanisms throughout Parkinson’s disease progression

  2025cites this paper
• Erasing “bad memories”: reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders

  2025influential citation
• Motor Learning-based Clinical Pilates Training for the Parkinson's Disease Rehabilitation @Parkinsonpilates: A Parallel Group, Randomised Controlled Trial with 3-Month Follow-up.

  2025cites this paper
• Rethinking the role of continuous dopaminergic stimulation in Parkinson disease therapy.

  2025cites this paper
• Kraft-Based Femtosecond Laser-Induced Graphene for Electrochemical Dopamine Sensing.

  2025cites this paper
• Disposable paper electrodes for detection of changes in dopamine concentrations in rat brain homogenates.

  2024cites this paper
• Neuronal plasticity and its role in Alzheimer’s disease and Parkinson’s disease

  2024cites this paper
• Clinically established early Parkinson's disease patients do not show impaired use of priors in conditions of perceptual uncertainty.

  2024influential citation
• Opposing Motor Memories in the Direct and Indirect Pathways of the Basal Ganglia

  2024cites this paper
• Antinociceptive role of the thalamic dopamine D3 receptor in descending modulation of intramuscular formalin-induced muscle nociception in a rat model of Parkinson's disease.

  2024cites this paper
• Long-term levodopa ameliorates sequence effect in simple, but not complex walking in early Parkinson's disease patients.

  2023cites this paper
• Apigenin: Exploring its neuroprotective potential in neurodegenerative disorders: Mechanisms and promising therapeutic applications

  2023cites this paper
• Designing environments that contribute to a reduction in the progression of Parkinson's disease; a literature review.

  2023cites this paper
• Substantia Nigra Pars Reticulata Projections to the Pedunculopontine Nucleus Modulate Dyskinesia

  2023cites this paper
• Motor Memory Consolidation Deficits in Parkinson’s Disease: A Systematic Review with Meta-Analysis

  2023cites this paper
• Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment

  2023cites this paper
• Antifouling for Electrochemically Biosensing in Body Fluids

  2023cites this paper
• Long‐Duration Response to Levodopa, Motor Learning, and Neuroplasticity in Early Parkinson's Disease

  2023cites this paper
• Scalable fabrication of graphene-assembled multifunctional electrode with efficient electrochemical detection of dopamine and glucose

  2023cites this paper
• Characterizing the relationship between L-DOPA-induced-dyskinesia and psychosis-like behaviors in a bilateral rat model of Parkinson's disease.

  2023cites this paper
• Depotentiation of associative plasticity is intact in Parkinson's disease with mild dyskinesia.

  2022cites this paper
• R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations

  2022influential citation
• β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression

  2022cites this paper
• Evidence of Neuroplastic Changes after Transcranial Magnetic, Electric, and Deep Brain Stimulation

  2022cites this paper
• Cortico-cortical connectivity is normalised by levodopa in tremor-dominant Parkinson's disease.

  2022cites this paper
• Screen-printed analytical strip constructed with bacteria-templated porous N-doped carbon nanorods/Au nanoparticles for sensitive electrochemical detection of dopamine molecules.

  2021cites this paper
• Flexible sensor with electrophoretic polymerized graphene oxide/PEDOT:PSS composite for voltammetric determination of dopamine concentration

  2021cites this paper
• Dissociable effects of age and Parkinson’s disease on instruction-based learning

  2021cites this paper
• Sonogenetic-Based Neuromodulation for the Amelioration of Parkinson's Disease.

  2021cites this paper
• Fiber-specific white matter alterations in early-stage tremor-dominant Parkinson’s disease

  2021cites this paper
• The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease

  2021cites this paper
• Flexible micro-sensors with self-assembled graphene on a polyolefin substrate for dopamine detection.

  2020cites this paper
• Fabrication of dopamine sensor based on ternary AlMn0.645Cr1.76O7.47 nanoparticles

  2020cites this paper
• Pathogenic LRRK2 R1441C mutation is associated with striatal alterations

  2020cites this paper
• Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

  2020cites this paper
• Dexmedetomidine Activation of Dopamine Neurons in the Ventral Tegmental Area Attenuates the Depth of Sedation in Mice

  2020cites this paper
• A non-linear deterministic model of action selection in the basal ganglia to simulate motor fluctuations in Parkinson's disease.

  2020cites this paper
• CeO2-Based Two-Dimensional Layered Nanocomposites Derived from a Metal–Organic Framework for Selective Electrochemical Dopamine Sensors

  2020cites this paper
• Nicotine in Aberrant Learning and Corticostriatal Plasticity

  2019cites this paper
• Selegiline Recovers Synaptic Plasticity in the Medial Prefrontal Cortex and Improves Corresponding Depression-Like Behavior in a Mouse Model of Parkinson’s Disease

  2019cites this paper
• Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning.

  2019cites this paper
• Dopamine modulates the size of striatal projection neuron ensembles

  2019cites this paper
• Dopamine differentially modulates the size of projection neuron ensembles in the intact and dopamine-depleted striatum

  2019cites this paper
• Aberrant learning in Parkinson's disease: A neurocomputational study on bradykinesia

  2018cites this paper
• Technologies of Nonlinear Stimulation: Role in the Treatment of Diseases of the Brain and the Potential Applications in Healthy Individuals

  2018cites this paper
• Positron emission tomography : development, evaluation and application of quantification methods

  2018cites this paper
• Sensory Neuromodulation

  2018cites this paper
• Unraveling connectivity changes due to dopaminergic therapy in chronically treated Parkinson’s disease patients

  2018cites this paper
• Modulatory Effects of Levodopa on Cerebellar Connectivity in Parkinson’s Disease

  2018cites this paper
• Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System.

  2018cites this paper
• Dopamine–endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum

  2018cites this paper
• To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity

  2018cites this paper
• Queens College 2-13-2018 To Do or Not to Do : Dopamine , Affordability and the Economics of Opportunity

  2018cites this paper
• Investigating The Acute Levodopa Response In Early To Advanced Parkinson’s Disease

  2017cites this paper
• The missing, the short, and the long: Levodopa responses and dopamine actions

  2017cites this paper
• Neuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease.

  2017cites this paper
• The Role of Primary Motor Cortex (M1) Glutamate and GABA Signaling in l-DOPA-Induced Dyskinesia in Parkinsonian Rats

  2016influential citation
• Chronic Nicotine Mitigates Aberrant Inhibitory Motor Learning Induced by Motor Experience under Dopamine Deficiency

  2016cites this paper
• Intrinsic circuits of the striatum

  2016cites this paper
• Modeling sleep alterations in Parkinson's disease: How close are we to valid translational animal models?

  2016cites this paper
• Neuronal firing patterns outweigh circuitry oscillations in parkinsonian motor control.

  2016cites this paper
• Switching L-dopa Therapy from Pulsatile to Pulse Administration Reduces Motor Complications in Parkinson's Disease

  2016cites this paper
• Electrochemical detection of nanomolar dopamine in the presence of neurophysiological concentration of ascorbic acid and uric acid using charge-coated carbon nanotubes via facile and green preparation.

  2016cites this paper
• An electrochemical sensor for selective detection of dopamine based on nickel tetrasulfonated phthalocyanine functionalized nitrogen-doped graphene nanocomposites

  2016cites this paper
• The Effects of Intensive Speech Treatment on Intelligibility in Spanish Speakers With Parkinson's Disease

  2016cites this paper
• Clinical and scientific perspectives on movement disorders: Stanley Fahn's contributions

  2015cites this paper
• Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease

  2015cites this paper
• Commonly-occurring polymorphisms in the COMT, DRD1 and DRD2 genes influence different aspects of motor sequence learning in humans.

  2015cites this paper
• Fractality of sensations and the brain health: the theory linking neurodegenerative disorder with distortion of spatial and temporal scale-invariance and fractal complexity of the visible world

  2015cites this paper
• Presynaptic effects of levodopa and their possible role in dyskinesia

  2015cites this paper
• Trends in Managing Parkinson’s Disease - A Review

  2014cites this paper
• Nicotinic receptors regulate the dynamic range of dopamine release in vivo.

  2014cites this paper
• Cortico-Striatal-Thalamic Network Functional Connectivity In Hemiparkinsonism (P2.001)

  2014cites this paper
• Mavoglurant as a treatment for Parkinson’s disease

  2014influential citation
• Cyclic AMP and Afferent Activity Govern Bidirectional Synaptic Plasticity in Striatopallidal Neurons

  2014cites this paper
• Dopamine receptor signaling in the forebrain

  2014influential citation
• Interpretive conundrums when practice doesn't always make perfect

  2014cites this paper
• Cortico-striatal-thalamic network functional connectivity in hemiparkinsonism.

  2014cites this paper
• Protective Effects of Ginkgo biloba Extract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development

  2014cites this paper
• The Enemy within: Propagation of Aberrant Corticostriatal Learning to Cortical Function in Parkinson’s Disease

  2013cites this paper
• , dopamine release in vivo Nicotinic receptors regulate the dynamic range of

  2013cites this paper
• Dopamine-endocannabinoid interactions mediate spike-timing dependent potentiation in the striatum

  year unknowninfluential citation