The Role of Small Extracellular Vesicles in Tumor Development and the Prospect of Targeted Therapy

Small extracellular vesicles (sEVs) originate from endosomes formed during cellular endocytosis, have a diameter ranging from 30 to 150 nm and are membrane‐bound prior to release, sEVs may also be formed by budding of the plasma membrane to form ectosomes. sEVs transport proteins, RNA, microRNAs (miRNAs), DNA, and other bioactive substances to facilitate information exchange and may function as mediators under physiological conditions. sEVs have various pathological roles, especially when produced by tumor parenchyma and stromal cells for signaling in the tumor‐induced microenvironment. The vesicles are considered potential tumor markers and there are broad prospects for developing tumor therapies by inhibiting sEV production, secretion and uptake and eliminating circulating sEVs. sEVs may be modified to deliver chemotherapeutic drugs and this approach has shown promising results for tumor inhibition and improved prognosis. The current study reviews the role of sEVs in tumor development and explores the potential for tumor treatment.

• Publication year

  2025

• Venue

  Traffic : the International Journal of Intracellular Transport

• Publication date

  2025-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/tra.70023PMID 41215625
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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