β-Glucans in Food Systems: Balancing Health, Safety, and Diabetes Prevention.

Addressing the global health challenge of type 2 diabetes requires safer therapeutic options beyond conventional treatments with known limitations. This systematic evaluation explores the potential of β-glucans from diverse sources in diabetes management. By integrating existing research on gut microbiota modulation and short-chain fatty acid metabolism, we elucidate the mechanisms through which β-glucans alleviate diabetes and its complications, including neurodegeneration, cardiovascular impairment, and renal fibrosis. The analysis reveals how β-glucans remodel microbial metabolic networks through short-chain fatty acid production and bile acid cycle regulation, modulate energy metabolism pathways, and disrupt oxidative stress-inflammatory crosstalk. Based on comprehensive safety assessments, we establish scientific intake guidelines while investigating β-glucans' structural stability and functional retention during food processing as well as their targeting efficiency and controlled-release properties as nanocarriers for drug delivery. This work provides a theoretical foundation for the dual application of β-glucans in precision nutrition and intelligent drug development for diabetes management.

• Publication year

  2025

• Venue

  Journal of Agricultural and Food Chemistry

• Publication date

  2025-11-10

• Fields of study

  Agricultural and Food Sciences, Medicine, Environmental Science

• Identifiers
  DOI 10.1021/acs.jafc.5c12704PMID 41212790
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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