Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Physiology

• Publication date

  2014-11-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/jphysiol.2014.278754PMID 25239459PMCID PMC4259537
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum

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• Quantifying colocalization by correlation: The Pearson correlation coefficient is superior to the Mander's overlap coefficient

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• Enhanced tonic GABAA inhibition in typical absence epilepsy

  2009cited by this paper
• Differential Tonic GABA Conductances in Striatal Medium Spiny Neurons

  2008influential reference
• Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex.

  2007cited by this paper
• Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene.

  2006cited by this paper
• Contributions of the GABAA Receptor α6 Subunit to Phasic and Tonic Inhibition Revealed by a Naturally Occurring Polymorphism in the α6 Gene

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• Astrocyte calcium elevations: Properties, propagation, and effects on brain signaling

  2006cited by this paper
• Astrocyte control of synaptic transmission and neurovascular coupling.

  2006cited by this paper
• Alcohol-induced motor impairment caused by increased extrasynaptic GABAA receptor activity

  2005cited by this paper
• An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.

  2005cited by this paper
• Astrocytes, from brain glue to communication elements: the revolution continues

  2005cited by this paper
• GABAA Receptor-Mediated Tonic Inhibition in Thalamic Neurons

  2005cited by this paper
• Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

  2005influential reference
• Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

  2004cited by this paper
• Tonically active GABA A receptors: modulating gain and maintaining the tone.

  2004cited by this paper
• Integration of quanta in cerebellar granule cells during sensory processing

  2004cited by this paper
• Quantitative electron microscopic immunocytochemistry of neuroactive amino acids

  2004cited by this paper
• Cre-lox-regulated conditional RNA interference from transgenes.

  2004cited by this paper
• Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors.

  2004cited by this paper
• Multiple modes of GABAergic inhibition of rat cerebellar granule cells

  2003influential reference
• Modulation of GABAA Receptors by Hydrogen Ions Reveals Synaptic GABA Transient and a Crucial Role of the Desensitization Process

  2003cited by this paper
• GAT-1 and reversible GABA transport in Bergmann glia in slices.

  2002cited by this paper
•   Receptors with Different Affinities Mediate Phasic and Tonic GABAA Conductances in Hippocampal Neurons

  2002cited by this paper
• Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells.

  2002cited by this paper
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  2001cited by this paper
• A monoclonal antibody against the glutaraldehyde-conjugated polyamine, putrescine: application to immunocytochemistry

  2001cited by this paper
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  1999cited by this paper
• Adaptive Changes in Postsynaptic Dopamine Receptors Despite Unaltered Dopamine Dynamics in Mice Lacking Monoamine Oxidase B

  1999cited by this paper
• Effect of selegiline on dopamine concentration in the striatum of a primate.

  1999cited by this paper
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  1999cited by this paper
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  1997cited by this paper
• Neuronal and glial localization of two GABA transporters (GAT1 and GAT3) in the rat cerebellum.

  1996cited by this paper
• Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors.

  1996cited by this paper
• Effect of Long‐Term Treatment with Selective Monoamine Oxidase A and B Inhibitors on Dopamine Release from Rat Striatum In Vivo

  1996cited by this paper
• Regulation of γ‐Aminobutyric Acid Synthesis in the Brain

  1993cited by this paper
• Regulation of gamma-aminobutyric acid synthesis in the brain.

  1993cited by this paper
• Characteristics of putrescine uptake and subsequent GABA formation in primary cultured astrocytes from normal C57BL/6J and epileptic DBA/2J mouse brain cortices.

  1992cited by this paper
• Ion channel expression by white matter glia: the type-1 astrocyte.

  1990cited by this paper
• Postembedding immunogold labelling of fixed glutamate: an electron microscopic analysis of the relationship between gold particle density and antigen concentration.

  1989cited by this paper
• GABA and its relationship to putrescine metabolism in the rat brain and pancreas.

  1987influential reference
• Neuronal and glial localization of acetylcholinesterase and GABA transaminase in organized cultures of developing rat spinal cord

  1983cited by this paper
• Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons.

  1982influential reference
• GABA metabolism in cultured glial cells.

  1979cited by this paper
• GABA metabolism in cultured glial cells

  1979influential reference
• Putrescine catabolism in mammalian brain.

  1974cited by this paper
• An estimation of the concentration of y-aminobutyric acid and glutamate decarboxylase in the inhibitory Purkinje axon terminals in the cat.

  1973cited by this paper
• Glial cell function: uptake of transmitter substances.

  1971cited by this paper
• The operation of the gamma-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro.

  1970cited by this paper

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