Nanovesicles from Rosa canina: A Treasure Trove of Antioxidant Potential for Oxidative Stress, Inflammation, and Gut Microbiota Modulation

Background/Objectives: Extracellular vesicles (EVs) have become key facilitators of communication between cells, significantly influencing various physiological functions. Although EVs originating from mammalian cells have been heavily researched for their therapeutic applications, there is a growing interest in extracellular vesicles derived from edible plants (PDEVs) because of their unique bioactive characteristics. These nanovesicles (NVs) exhibit remarkable biocompatibility, low immunogenicity, and the ability to overcome biological barriers, making them promising candidates for biomedical applications. This study aimed to evaluate the antioxidant and anti-inflammatory properties of NVs isolated from Rosa canina berries. Methods: Antioxidant activity was assessed through in vitro assays, confirming their ability to fight oxidative stress. Additionally, enzymatic inhibition tests were conducted to explore their potential role in regulating key metabolic pathways associated with inflammation and oxidative damage. The antioxidant and anti-inflammatory activity of Rosa canina NVs was further tested on a THP-1 cell-based inflammation model, demonstrating their ability to modulate the inflammatory response at the cellular level. Moreover, the impact of these NVs on gut microbiota was investigated to assess their protective effects on antibiotic-induced dysbiosis. Results: The results demonstrated their ability to modulate oxidative stress, regulate enzymatic pathways, reduce inflammation in THP-1 cells, and influence gut microbiota in a positive manner.

• Publication year

  2025

• Venue

  Pharmaceuticals

• Publication date

  2025-11-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3390/ph18111672PMID 41304917PMCID 12655377
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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