Maternal Diet‐Induced Excess Adiposity in Mice Disrupts Mid‐Gestation Decidual Immune and Vascular Homeostasis Without Impairing Spiral Artery Remodeling

Maternal excess adiposity (i.e., overweight/obesity) is linked to impaired uteroplacental perfusion, compromised placental development, and increased risk of adverse pregnancy outcomes. Inflammation and immune dysregulation accompanying excess adiposity may disrupt leukocyte‐mediated tissue remodeling and immunoregulation, contributing to placental dysfunction. However, the impacts of excess adiposity on populations of innate lymphoid cells and macrophages orchestrating these processes, and on the decidual microenvironment, remain understudied. Here, we used a mouse model of high‐fat, high‐sucrose (HFHS) diet‐feeding to study the impacts of excess adiposity on decidual immune dynamics during placental development.

• Publication year

  2025

• Venue

  Acta Physiologica

• Publication date

  2025-11-11

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1111/apha.70130PMID 41217975PMCID 12604746
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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