Fingolimod Exerts Therapeutic Effects on Autistic Mice via Improving the Structure and Function of Meningeal Lymphatics

Accumulating evidence suggests a correlation between maternal infection during pregnancy and an increased risk of autism spectrum disorder (ASD) in offspring. Our previous studies have demonstrated that maternal immune activation (MIA) induces autism‐like behaviors in offspring mice, accompanied by significant lateral ventricular enlargement and cerebrospinal fluid (CSF) circulation deficits. As a critical pathway for CSF drainage, the role of meningeal lymphatic vessels in the pathophysiology of ASD remains uncharacterized. Fingolimod (FTY720), a clinically used immunomodulator, has been shown to ameliorate autism‐like behaviors, but its underlying mechanism remains unclear.

• Publication year

  2025

• Venue

  CNS Neuroscience & Therapeutics

• Publication date

  2025-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/cns.70649PMID 41220090PMCID 12606008
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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