Genetic targeting of premyelinating oligodendrocytes reveals activity-dependent myelination mechanisms

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Nature Neuroscience

• Publication date

  2025-11-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41593-025-02110-1PMID 41219502
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2018cited by this paper
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  2018cited by this paper
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• Maturation-Dependent Vulnerability of Perinatal White Matter in Premature Birth

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• Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells.

  2003cited by this paper
• Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis.

  2002cited by this paper
• Differentiation and Death of Premyelinating Oligodendrocytes in Developing Rodent Brain

  1997cited by this paper
• Changes in glial K+ currents with decreased extracellular volume in developing rat white matter

  1997cited by this paper
• Expression of the APC tumor suppressor protein in oligodendroglia

  1996cited by this paper
• Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons

  1993cited by this paper
• Cell death and control of cell survival in the oligodendrocyte lineage.

  1992cited by this paper
• Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10

  1989cited by this paper
• High prealbumin and transferrin mRNA levels in the choroid plexus of rat brain.

  1985cited by this paper

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