Differentiation and Death of Premyelinating Oligodendrocytes in Developing Rodent Brain

Previous studies have indicated that newly formed oligodendrocytes are dynamic cells whose production, survival, and differentiation depend upon axonal influences. This study has characterized the appearance and fate of newly formed oligodendrocytes in developing rat brain. Oligodendrocytes appear in predictable locations and radially extend DM-20–positive processes that cover 80-μm domains in the cortex and 40-μm domains in the corpus callosum. These premyelinating oligodendrocytes have one of two fates: they myelinate axons or degenerate. Between 7 and 21 d after birth, ∼20% of premyelinating oligodendrocytes identified in the cerebral cortex were degenerating. Oligodendrocytes that ensheathed axons expressed and selectively targeted proteolipid protein to compact myelin and did not degenerate. These observations support the hypothesis that axonal influences affect oligodendrocyte survival, differentiation, and expression of proteolipid protein gene products.

• Publication year

  1997

• Venue

  Journal of Cell Biology

• Publication date

  1997-04-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/JCB.137.2.459PMID 9128255PMCID 2139778
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oligodendrocyte progenitors are generated throughout the embryonic mouse brain, but differentiate in restricted foci.

  1996cited by this paper
• Oligodendrocyte origins.

  1996cited by this paper
• Axons regulate the distribution of Schwann cell microtubules

  1996cited by this paper
• Glial cells are increased proportionally in transgenic optic nerves with increased numbers of axons

  1996influential reference
• Parallel evolution and coexpression of the proteolipid proteins and protein zero in vertebrate myelin.

  1996cited by this paper
• Interaction between NG2 proteoglycan and PDGF α‐receptor on O2A progenitor cells is required for optimal response to PDGF

  1996influential reference
• Co‐localization of NG2 proteoglycan and PDGF α‐receptor on O2A progenitor cells in the developing rat brain

  1996influential reference
• Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression

  1995influential reference
• Control of oligodendrocyte number in the developing rat optic nerve.

  1994cited by this paper
• Molecular cloning of M6: identification of a PLP/DM20 gene family.

  1993cited by this paper
• Programmed cell death and the control of cell survival: lessons from the nervous system.

  1993cited by this paper
• A proteolipid protein gene family: expression in sharks and rays and possible evolution from an ancestral gene encoding a pore-forming polypeptide.

  1993cited by this paper
• Development and differentiation of glial precursor cells in the rat cerebellum

  1993influential reference
• Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain.

  1993cited by this paper
• A singularity of PDGF alpha-receptor expression in the dorsoventral axis of the neural tube may define the origin of the oligodendrocyte lineage.

  1993cited by this paper
• Does oligodendrocyte survival depend on axons?

  1993cited by this paper
• Glial cell mitogens bFGF and PDGF differentially regulate development of O4+GalC- oligodendrocyte progenitors.

  1993cited by this paper
• The oligodendrocyte and its many cellular processes.

  1993cited by this paper
• Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons

  1993cited by this paper
• Plasma membrane protein sorting in polarized epithelial cells

  1992cited by this paper
• A division too far?

  1992cited by this paper
• Proligodendroblast Antigen (POA), a Developmental Antigen Expressed by A007/O4‐Positive Oligodendrocyte Progenitors Prior to the Appearance of Sulfatide and Galactocerebroside

  1992cited by this paper
• Cell death and control of cell survival in the oligodendrocyte lineage.

  1992influential reference
• PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage.

  1992cited by this paper
• Proliferation and differentiation of O4+ oligodendrocytes in postnatal rat cerebellum: Analysis in unfixed tissue slices using anti‐glycolipid antibodies

  1992cited by this paper
• Polarity of epithelial and neuronal cells.

  1992cited by this paper
• Proliferation and differentiation potential of rat forebrain oligodendroglial progenitors both in vitro and in vivo.

  1991influential reference
• Two proliferative stages of the oligodendrocyte lineage (A2B5+O4- and O4+GalC-) under different mitogenic control.

  1990cited by this paper
• PDGF receptors on cells of the oligodendrocyte-type-2 astrocyte (O-2A) cell lineage.

  1989cited by this paper
• The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes

  1989cited by this paper
• PDGF and intracellular signaling in the timing of oligodendrocyte differentiation

  1989cited by this paper
• A role for platelet-derived growth factor in normal gliogenesis in the central nervous system.

  1988cited by this paper
• Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum

  1988cited by this paper
• Spatial segregation of mRNA encoding myelin-specific proteins.

  1987cited by this paper
• Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficit

  1986cited by this paper
• A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium

  1983cited by this paper
• Increased proliferation of oligodendrocytes in the hypomyelinated mouse mutant-jimpy.

  1982cited by this paper
• Synthesis and incorporation of myelin polypeptides into CNS myelin

  1982cited by this paper
• ACCUMULATION OF THE FOUR MYELIN BASIC PROTEINS IN MOUSE BRAIN DURING DEVELOPMENT 1

  1978cited by this paper
• Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation.

  1978cited by this paper
• Myelin-associated glycoprotein: a developmental change.

  1973cited by this paper

• Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors.

  2026cites this paper
• Meeting the need for myelin.

  2026cites this paper
• Premyelinating Oligodendrocyte Survival Governs CNS Remyelination

  2026influential citation
• Maternal SSRI Use During Pregnancy: Links Between Gut Microbiome, Offspring Behaviour, and Brain Transcriptomics.

  2025cites this paper
• Oligodendrocyte arrangement, identification and morphology in the developing superior olivary complex

  2025cites this paper
• Impaired remyelination in late-onset multiple sclerosis

  2025cites this paper
• Identifying Lanthionine Ketimine Derivatives for Maturation and Proliferative Effects in Oligodendrocyte Progenitor Cells

  2025cites this paper
• Are Oligodendrocytes the Culprits or Victims in Alzheimer’s Disease

  2025cites this paper
• Effect of Cytoskeletal Linker Protein GAS2L1 on Oligodendrocyte and Myelin Development

  2025cites this paper
• Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development

  2025cites this paper
• Impaired maturation and differentiation of oligodendrocytes in the vacuole formation myelin mutant rat

  2025cites this paper
• Transient Upregulation of Procaspase-3 during Oligodendrocyte Fate Decisions

  2025cites this paper
• Genetic targeting of premyelinating oligodendrocytes reveals activity-dependent myelination mechanisms

  2025cites this paper
• Transient upregulation of procaspase-3 during oligodendrocyte fate decisions

  2024influential citation
• Utilizing hiPSC-derived oligodendrocytes to study myelin pathophysiology in neuropsychiatric and neurodegenerative disorders.

  2024cites this paper
• Genetically Labeled Premyelinating Oligodendrocytes: Bridging Oligodendrogenesis and Neuronal Activity

  2024cites this paper
• Regulators of Oligodendrocyte Differentiation.

  2024cites this paper
• Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system

  2024cites this paper
• Visualization of myelin‐forming oligodendrocytes in the adult mouse brain

  2024cites this paper
• Features, Fates, and Functions of Oligodendrocyte Precursor Cells.

  2023cites this paper
• Oligodendrocyte Development and Myelin Sheath Formation are Regulated by the Antagonistic Interaction between the Rag-Ragulator Complex and TFEB

  2023cites this paper
• Cleavage of VAMP2/3 Affects Oligodendrocyte Lineage Development in the Developing Mouse Spinal Cord

  2023cites this paper
• Repetitive transcranial magnetic stimulation and fluoxetine reverse depressive-like behavior but with differential effects on Olig2-positive cells in chronically stressed mice

  2023cites this paper
• Oligodendrocyte Maturation Alters the Cell Death Mechanisms That Cause Demyelination

  2023cites this paper
• Development of myelin in fetal and postnatal neocortex of the pig, the European wild boar Sus scrofa

  2023cites this paper
• The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells

  2023cites this paper
• Norepinephrine regulates calcium signals and fate of oligodendrocyte precursor cells in the mouse cerebral cortex

  2023cites this paper
• Oligodendrocyte progenitor development from the postnatal rat subventricular zone is regulated by the p75 neurotrophin receptor.

  2023cites this paper
• Autophagy collaborates with apoptosis pathways to control oligodendrocyte number

  2023cites this paper
• Markers of Neuroontogenesis in the Stress-Hyporesponsive Period: a Comparison of Laboratory Rodents and Humans

  2023cites this paper
• Autophagy collaborates with apoptosis pathways to control myelination specificity and function

  2023cites this paper
• Early cortical oligodendrocyte precursor cells are transcriptionally distinct and lack synaptic connections

  2023cites this paper
• Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity.

  2022cites this paper
• mRNA Localization to the Endoplasmic Reticulum in Plant Endosperm Cells

  2022cites this paper
• Regulation of oligodendrocyte lineage development by VAMP2/3 in the developing mouse spinal cord

  2022cites this paper
• Isolated catatonia-like executive dysfunction in mice with forebrain-specific loss of myelin integrity

  2022cites this paper
• Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation

  2022cites this paper
• Separate optogenetic manipulation of Nerve/glial antigen 2 (NG2) glia and mural cells using the NG2 promoter

  2022cites this paper
• Presentation and integration of multiple signals that modulate oligodendrocyte lineage progression and myelination

  2022cites this paper
• Development of myelinating glia: An overview

  2022cites this paper
• Spatial and temporal heterogeneity in the lineage progression of fine oligodendrocyte subtypes

  2022cites this paper
• Norepinephrine regulates Ca2+ signals and fate of oligodendrocyte progenitor cells in the cortex

  2022cites this paper
• Pinch2 is a novel regulator of myelination in the Central Nervous System

  2022cites this paper
• Emerging mitochondrial‐mediated mechanisms involved in oligodendrocyte development

  2022cites this paper
• Attack of the Clones: Microglia in Health and Disease

  2022cites this paper
• Phagocytic astrocytes: Emerging from the shadows of microglia

  2022cites this paper
• Semaphorins in Adult Nervous System Plasticity and Disease

  2021cites this paper
• Canavan Disease as a Model for Gene Therapy-Mediated Myelin Repair

  2021cites this paper
• Advances in venom peptide drug discovery: where are we at and where are we heading?

  2021cites this paper
• Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders

  2021cites this paper
• Microglia phagocytose oligodendrocyte progenitor cells and synapses during early postnatal development: implications for white versus gray matter maturation

  2021cites this paper
• Myelin: A gatekeeper of activity-dependent circuit plasticity?

  2021cites this paper
• Life-long oligodendrocyte development and plasticity

  2021cites this paper
• Spatial cell type mapping of the oligodendrocyte lineage in the mouse juvenile and adult CNS with in situ sequencing

  2021cites this paper
• Regional diversity in oligodendrocyte progenitor cells

  2021cites this paper
• Interaction between Neurons and the Oligodendroglial Lineage in Multiple Sclerosis and Its Preclinical Models

  2021cites this paper
• Building a (w)rapport between neurons and oligodendroglia: reciprocal interactions underlying adaptive myelination.

  2021cites this paper
• Regulation of myelination by microglia

  2021cites this paper
• White-Matter Repair as a Novel Therapeutic Target for Early Adversity

  2021cites this paper
• Premyelinating Oligodendrocytes: Mechanisms Underlying Cell Survival and Integration

  2021cites this paper
• Ion Channels as New Attractive Targets to Improve Re-Myelination Processes in the Brain

  2021cites this paper
• Oligodendrogenesis and myelination regulate cortical development, plasticity and circuit function.

  2021cites this paper
• Live imaging of remyelination in the adult mouse corpus callosum

  2021cites this paper
• Oligodendrocytic Na+-K+-Cl– co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain

  2021cites this paper
• Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury.

  2021cites this paper
• Oligodendrogenesis and myelin formation in the forebrain require platelet-derived growth factor receptor-alpha.

  2020cites this paper
• Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination

  2020cites this paper
• Matrix metalloproteinases shape the oligodendrocyte (niche) during development and upon demyelination.

  2020cites this paper
• The Effect of Chronic Ethanol Exposure and Thiamine Deficiency on Myelin-related Genes in the Cortex and the Cerebellum.

  2020cites this paper
• Macroglial diversity and its effect on myelination

  2020cites this paper
• GDE2-Dependent Activation of Canonical Wnt Signaling in Neurons Regulates Oligodendrocyte Maturation

  2020cites this paper
• Multiscale and multimodal reconstruction of cortical structure and function

  2020cites this paper
• Remyelination alters the pattern of myelin in the cerebral cortex

  2020cites this paper
• Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies.

  2020cites this paper
• Neuron–glial interactions and neurotransmitter signaling to cells of the oligodendrocyte lineage

  2020cites this paper
• Thyroid hormone and thyromimetics inhibit myelin and axonal degeneration and oligodendrocyte loss in EAE

  2020cites this paper
• Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function

  2020cites this paper
• Environmental enrichment ameliorates perinatal brain injury and promotes functional white matter recovery

  2020cites this paper
• Disorders of myelin

  2020cites this paper
• Kv1.3 Channel as a Key Therapeutic Target for Neuroinflammatory Diseases: State of the Art and Beyond

  2020cites this paper
• Macroglial diversity: white and grey areas and relevance to remyelination

  2020cites this paper
• Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Is a Negative Regulator of Oligodendrocyte Progenitor Cell Differentiation in the Adult Mouse Brain

  2020cites this paper
• Sustained ErbB Activation Causes Demyelination and Hypomyelination by Driving Necroptosis of Mature Oligodendrocytes and Apoptosis of Oligodendrocyte Precursor Cells

  2020cites this paper
• Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axis

  2020cites this paper
• Development of type I/II oligodendrocytes regulated by teneurin-4 in the murine spinal cord

  2020cites this paper
• Neuron-Oligodendroglia Interactions: Activity-Dependent Regulation of Cellular Signaling.

  2020cites this paper
• Defective myelination in an RNA polymerase III mutant leukodystrophic mouse

  2020cites this paper
• Probing disrupted neurodevelopment in autism using human stem cell‐derived neurons and organoids: An outlook into future diagnostics and drug development

  2020cites this paper
• Plasticity in oligodendrocyte lineage progression: An OPC puzzle on our nerves

  2020cites this paper
• Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial.

  2019cites this paper
• Developmental Cell Death in the Cerebral Cortex.

  2019cites this paper
• mRNA localization in plant cells

  2019cites this paper
• Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination

  2019cites this paper
• mRNA localization in plant cells

  2019cites this paper
• Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain.

  2019cites this paper
• Uncovering the biology of myelin with optical imaging of the live brain

  2019cites this paper
• The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation.

  2019cites this paper
• Oligodendrocytes in Development, Myelin Generation and Beyond

  2019cites this paper
• Axoglial interactions in myelin plasticity: Evaluating the relationship between neuronal activity and oligodendrocyte dynamics

  2019cites this paper
• Grey matter myelination

  2019cites this paper