A novel approach to the prevention and management of cardiovascular diseases: targeting brain–heart axis

Epidemiological studies indicate that cardiovascular diseases are the leading cause of death and disability worldwide, imposing a significant socioeconomic burden. Despite continuous medical advancements and new preventive measures offering new prospects for the treatment of cardiovascular diseases, the incidence and mortality rates remain high, presenting a challenging outlook for prevention and treatment. Exploring new strategies for preventing and treating cardiovascular diseases has become particularly urgent. The recent research has shown a close relationship between heart health and brain health. The autonomic neural central network in the brain regulates heart function through efferent activities. Cardiac dysfunction leads to afferent remodeling of the heart, adversely affecting central neural circuits and impairing higher brain functions, hence giving rise to the “brain–heart axis” concept. In the recent years, the concept of the brain–heart axis has been further refined into the brain–heart axis and heart–brain axis. The brain–heart axis has become a new target for preventing and treating cardiovascular diseases. Establishing a comprehensive theoretical and mechanistic framework of the brain–heart axis is essential for enhancing our systematic understanding of the pathophysiological mechanisms of cardiovascular diseases and finding new therapeutic approaches. We will explore brain–heart interactions, including ischemic stroke-induced, stress-induced, and neurodegenerative cardiac damage, and discuss the potential mechanisms behind these interactions. In addition, we will summarize research on targeted brain function activity detection and cardiovascular disease prevention, aiming to provide references for future in-depth research and precision treatment in targeting brain regions for cardiovascular disease prevention.

• Publication year

  2025

• Venue

  European Journal of Medical Research

• Publication date

  2025-11-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/s40001-025-03295-8PMID 41219820PMCID 12606839
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fluorescent Tagging of Endogenous FOXO for Live Imaging and Pull-Down Assays.

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• Deep brain stimulation of anterior nucleus and centromedian nucleus of thalamus in treatment for drug-resistant epilepsy.

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• Electroacupuncture alleviates myocardial ischemia–reperfusion injury by inhibiting hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla

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  2024cited by this paper
• Transcutaneous auricular vagus nerve stimulation ameliorates adolescent depressive‐ and anxiety‐like behaviors via hippocampus glycolysis and inflammation response

  2024cited by this paper
• The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: A comprehensive review.

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• Intracortical brain‐heart interplay: An EEG model source study of sympathovagal changes

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• Targeting Prefrontal Cortex Dysfunction in Pain

  2024cited by this paper
• Pharmacological mechanisms of puerarin in the treatment of Parkinson's disease: An overview.

  2024cited by this paper
• Deep brain stimulation of the amygdala for treatment-resistant combat post-traumatic stress disorder: Long-term results.

  2024cited by this paper
• Amygdala and hippocampal substructure volumes and their association with improvement in mood symptoms in patients with mood disorders undergoing electroconvulsive therapy.

  2024cited by this paper
• Activation AMPK in Hypothalamic Paraventricular Nucleus Improves Renovascular Hypertension Through ERK1/2-NF-κB Pathway

  2024cited by this paper
• Feedforward inhibition of stress by brainstem neuropeptide Y neurons

  2024cited by this paper
• Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension.

  2024cited by this paper
• A 4-week morning light treatment reduces amygdala reactivity and clinical symptoms in adults with traumatic stress.

  2024cited by this paper
• Brain-Heart Axis and the Inflammatory Response: Connecting Stroke and Cardiac Dysfunction

  2024cited by this paper
• (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

  2024cited by this paper
• Functional connectivity of the amygdala subregions and the antidepressant effects of repeated ketamine infusions in major depressive disorder

  2024cited by this paper
• Mechanism of Salvia miltiorrhiza Bunge extract to alleviate Chronic Sleep Deprivation-Induced cognitive dysfunction in rats.

  2024cited by this paper
• The brain-heart axis: Integrative analysis of the shared genetic etiology between neuropsychiatric disorders and cardiovascular disease.

  2024cited by this paper
• Hippocampal volume and cognitive performance in children with congenital heart disease

  2023cited by this paper
• Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

  2023cited by this paper
• Amygdala‐related electroencephalogram neurofeedback as add‐on therapy for treatment‐resistant childhood sexual abuse posttraumatic stress disorder: feasibility study

  2023cited by this paper
• Altered Neuronal Discharge in the Organum Vasculosum of the Lamina Terminalis Contributes to Dahl Salt-Sensitive Hypertension

  2023cited by this paper
• Cardiogenic control of affective behavioural state

  2023cited by this paper
• Imaging in Interventional Radiology: 2043 and Beyond.

  2023cited by this paper
• Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis.

  2023cited by this paper
• Neuroimmunomodulation of vagus nerve stimulation and the therapeutic implications

  2023cited by this paper
• Advancements and challenges in neuromodulation technology: interdisciplinary opportunities and collaborative endeavors.

  2023cited by this paper
• The role of prefrontal cortex and temporoparietal junction in interpersonal comfort and emotional approach

  2023cited by this paper
• Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia

  2023cited by this paper
• Capsaicin improves hypertension and cardiac hypertrophy via SIRT1/NF-κB/MAPKs pathway in the hypothalamic paraventricular nucleus.

  2023cited by this paper
• Cardiovascular disease and depression: a narrative review

  2023cited by this paper
• Electroacupuncture promotes the repair of the damaged spinal cord in mice by mediating neurocan‐perineuronal net

  2023cited by this paper
• Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation

  2023cited by this paper
• Thalamocortical Mechanisms Underlying Real and Imagined Acupuncture

  2023cited by this paper
• Functional network dynamics between the anterior thalamus and the cortex in deep brain stimulation for epilepsy.

  2023cited by this paper
• Age at cardiovascular disease onset, dementia risk, and the role of lifestyle factors

  2023cited by this paper
• Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway.

  2023cited by this paper
• Participation of the nucleus tractus solitarius in the therapeutic effect of electroacupuncture on post‐stroke dysphagia through the primary motor cortex

  2023cited by this paper
• Inflammation and cholesterol as predictors of cardiovascular events among patients receiving statin therapy: a collaborative analysis of three randomised trials.

  2023cited by this paper
• The regulations on cortical activation and functional connectivity of the dorsolateral prefrontal cortex-primary somatosensory cortex elicited by acupuncture with reinforcing-reducing manipulation

  2023cited by this paper
• Puerarin prevents sepsis-associated encephalopathy by regulating the AKT1 pathway in microglia.

  2023cited by this paper
• The Brain–Heart Axis: Neuroinflammatory Interactions in Cardiovascular Disease

  2023cited by this paper
• Stress induced proinflammatory adaptations: Plausible mechanisms for the link between stress and cardiovascular disease

  2023cited by this paper
• Neuroimmune cardiovascular interfaces control atherosclerosis

  2022cited by this paper
• Microglia-mediated neuroinflammation and neuroplasticity after stroke

  2022cited by this paper
• Psychological Stress and Heart Disease: Fact or Folklore?

  2022cited by this paper
• New Insights Into the Role of Inflammation in the Brain in Heart Failure

  2022cited by this paper
• Systemic inflammation after stroke: implications for post‐stroke comorbidities

  2022cited by this paper
• New Mechanisms and Targets of Subarachnoid Hemorrhage: A Focus on Mitochondria

  2022cited by this paper
• Cardiovascular therapeutics: A new potential for anxiety treatment?

  2022cited by this paper
• Crosstalk between the Gut and Brain in Ischemic Stroke: Mechanistic Insights and Therapeutic Options

  2022cited by this paper
• Real-world data of non-invasive stimulation of the human insula-prefrontal cortices using deep TMS to treat anxiety for occupational stress and generalized anxiety disorder.

  2022cited by this paper
• Adipsin as a novel prognostic biomarker for cardiovascular diseases

  2022cited by this paper
• Takotsubo syndrome: A current review of presentation, diagnosis, and management.

  2022cited by this paper
• Mental Stress-Induced Myocardial Ischemia

  2022cited by this paper
• Transition metal–free ketene formation from carbon monoxide through isolable ketenyl anions

  2022cited by this paper
• The hippocampus, ventromedial prefrontal cortex, and episodic and semantic memory.

  2022cited by this paper
• Molecular imaging of the brain–heart axis provides insights into cardiac dysfunction after cerebral ischemia

  2022cited by this paper
• Do any kinds of perceived stressors lead to hypertension? A longitudinal cohort study

  2022cited by this paper
• Takotsubo Syndrome: Pathophysiology, Emerging Concepts and Clinical Implications

  2022cited by this paper
• Allostatic Load and Mortality: A Systematic Review and Meta-Analysis.

  2022cited by this paper
• CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats

  2022cited by this paper
• Novel Mechanisms and Therapeutic Targets for Ischemic Stroke: A Focus on Gut Microbiota

  2022cited by this paper
• Neurometabolism and Ventricular Dyssynchrony in Patients With Heart Failure and Reduced Ejection Fraction.

  2022cited by this paper
• Autonomic Neural Circuit and Intervention for Comorbidity Anxiety and Cardiovascular Disease

  2022cited by this paper
• OUP accepted manuscript

  2022cited by this paper
• Summary of Global Burden of Disease Study Methods.

  2022cited by this paper
• Stroke–Heart Syndrome: Recent Advances and Challenges

  2022influential reference
• Heart-brain interactions in cardiac and brain diseases: why sex matters.

  2022cited by this paper
• Mental Stress and Its Effects on Vascular Health

  2022cited by this paper
• [Role of the Vagus Nerve in the Gut-Brain Axis: Development and Maintenance of Gut Regulatory T Cells via the Liver-Brain-Gut Vago-Vagal Reflex].

  2022cited by this paper
• The association between cardiovascular drugs and depression/anxiety in patients with cardiovascular disease: a meta-analysis.

  2021cited by this paper
• Activation of the Organum Vasculosum of the Lamina Terminalis Produces a Sympathetically Mediated Hypertension

  2021cited by this paper
• The World Stroke Organization Brain & Heart Task Force: collaborations between stroke physicians and cardiologists.

  2021cited by this paper
• Expressions of emotions across species

  2021cited by this paper
• Vagus nerve stimulation activates nucleus of solitary tract neurons via supramedullary pathways

  2021cited by this paper
• Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation

  2021cited by this paper
• Heart health meets cognitive health: evidence on the role of blood pressure.

  2021cited by this paper
• Macrophage depletion in stellate ganglia alleviates cardiac sympathetic overactivation and ventricular arrhythmogenesis by attenuating neuroinflammation in heart failure

  2021cited by this paper
• The brain remembers where and how inflammation struck.

  2021cited by this paper
• Inflammation in Human Heart Failure: Major Mediators and Therapeutic Targets

  2021cited by this paper
• The role of prefrontal cortex in cognitive control and executive function

  2021cited by this paper
• The heart is lost without the hypothalamus.

  2021cited by this paper
• Chronic Stress and Endothelial Dysfunction: Mechanisms, Experimental Challenges and Way Ahead.

  2020cited by this paper
• Cell-Type-Specific Outcome Representation in the Primary Motor Cortex.

  2020cited by this paper
• Impact of Acute and Chronic Stress on Thrombosis in Healthy Individuals and Cardiovascular Disease Patients

  2020cited by this paper
• Inflammation and cardiovascular disease: From mechanisms to therapeutics

  2020cited by this paper
• Good taste or gut feeling? A new method in rats shows oro‐sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns

  2020cited by this paper
• Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in Psoriasis: A Prospective Cohort Study.

  2020cited by this paper
• First-ever ischemic stroke and increased risk of incident heart disease in older adults

  2020cited by this paper

• Blood Pressure Management in Acute Ischemic Stroke

  2025cites this paper