Extracellular Vesicles from the Myocyte Secretome Contribute In Vitro to Creating an Unfavourable Environment for Migrating Lung Carcinoma Cells

Simple Summary Skeletal muscle is rarely affected by cancer, which indicates that these muscle cells contain cancer-resistant properties. Cells release small membrane vesicles, extracellular vesicles (EVs), which are important for communication between cells, and may be protective if released from certain cells, but can also contribute to disease signalling, including in cancer. In this study, we isolated EVs from skeletal muscle cells and applied them to lung cancer cells. We found that the skeletal muscle EVs have anti-cancer signatures and stopped the cancer cells from spreading and caused them to die. Our findings highlight the potential of skeletal muscle EVs as anti-cancer agents and the importance of skeletal muscle and their EVs in healthy ageing and to protect human health in conditions when skeletal muscle mass is compromised.

• Publication year

  2025

• Venue

  Biology

• Publication date

  2025-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/biology14111578PMID 41300368PMCID 12650371
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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