Erythropoietin: Physiology and Pharmacology Update 2

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Experimental biology and medicine

• Publication date

  2003-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1177/153537020322800101PMID 12524467
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A good response rate to recombinant erythropoietin alone may be expected in selected myelodysplastic patients. A preliminary clinical study

  2009cited by this paper
• Haemopoietic stem cells.

  2004cited by this paper
• Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin.

  2002cited by this paper
• New insights into erythropoiesis

  2002cited by this paper
• Erythropoietin in the central nervous system, and its use to prevent hypoxic‐ischemic brain damage

  2002cited by this paper
• An overview of the efficacy and safety of novel erythropoiesis stimulating protein (NESP).

  2001cited by this paper
• The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif.

  2001cited by this paper
• HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

  2001cited by this paper
• Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

  2001cited by this paper
• Effects of epoetin alfa on hematologic parameters and quality of life in cancer patients receiving nonplatinum chemotherapy: results of a randomized, double-blind, placebo-controlled trial.

  2001cited by this paper
• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

  2001cited by this paper
• Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain

  2001cited by this paper
• Development and characterization of novel erythropoiesis stimulating protein (NESP)

  2001cited by this paper
• HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

  2001cited by this paper
• Cardiovascular effects of erythropoietin and anemia correction

  2001cited by this paper
• Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor.

  2001cited by this paper
• Signal transduction. How do cells sense oxygen?

  2001cited by this paper
• [Do cells sense oxygen?].

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• A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF

  2001cited by this paper
• Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin.

  2001cited by this paper
• Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing.

  2001cited by this paper
• Adenosine A(2A) and A(2B) receptor activation of erythropoietin production.

  2001cited by this paper
• Role of uremic toxins in exacerbating anemia in renal failure.

  2001cited by this paper
• Novel erythropoiesis stimulating protein for treatment of anemia in chronic renal insufficiency.

  2001cited by this paper
• Independent function of two destruction domains in hypoxia‐inducible factor‐α chains activated by prolyl hydroxylation

  2001cited by this paper
• The distal region and receptor tyrosines of the Epo receptor are non‐essential for in vivo erythropoiesis

  2001cited by this paper
• Sports Haematology

  2000cited by this paper
• NOVEL ERYTHROPOIESIS STIMULATING PROTEIN (NESP) MAINTAINS HAEMOGLOBIN IN ESRD PATIENTS WHEN ADMINISTERED ONCE WEEKLY OR ONCE EVERY OTHER WEEK

  2000cited by this paper
• Early epoetin treatment in patients with renal insufficiency.

  2000cited by this paper
• Current concepts of anemia management in chronic renal failure: impact of NKF-DOQI.

  2000cited by this paper
• European best practice guidelines 5: target haemoglobin.

  2000cited by this paper
• Erythropoietin test methods.

  2000cited by this paper
• JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells.

  2000cited by this paper
• Erythropoietin regulates vascular smooth muscle cell apoptosis by a phosphatidylinositol 3 kinase-dependent pathway.

  2000cited by this paper
• Current concepts of anemia management in chronic renal failure: impact of NKF-DOQI.

  2000cited by this paper
• Protein Kinase C α Controls Erythropoietin Receptor Signaling*

  2000cited by this paper
• Novel erythropoiesis stimulating protein.

  2000cited by this paper
• An In Vitro Model for the Study of Human Bone Marrow Angiogenesis: Role of Hematopoietic Cytokines

  2000cited by this paper
• Use of recombinant human erythropoietin as an antianemic and performance enhancing drug.

  2000cited by this paper
• Morphologic and Functional Changes of Left Ventricle in Dialyzed Patients After Treatment with Recombinant Human Erythropoietin (r-HuEPO)

  2000cited by this paper
• Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

  2000cited by this paper
• Erythropoietin Receptors That Signal Through Stat5 or Stat3 Support Fetal Liver and Adult Erythropoiesis: Lack of Specificity of Stat Signals During Red Blood Cell Development

  2000cited by this paper
• Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo.

  1999cited by this paper
• Erythropoietin receptor activation by a ligand-induced conformation change.

  1999cited by this paper
• Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation.

  1999cited by this paper
• Inhibition of CFU-E colony formation in uremic patients with inflammatory disease: role of IFN-gamma and TNF-alpha.

  1999cited by this paper
• Pharmacokinetics of novel erythropoiesis stimulating protein compared with epoetin alfa in dialysis patients.

  1999cited by this paper
• Differential effects of endothelin-1 antagonists on erythropoietin-induced hypertension in renal failure.

  1999cited by this paper
• Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

  1999cited by this paper
• Stimulation of Expression for the Adenosine A2A Receptor Gene by Hypoxia in PC12 Cells

  1999cited by this paper
• Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1.

  1999cited by this paper
• The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

  1999cited by this paper
• Mechanisms of the potentiation by adenosine of adenosine triphosphate-induced calcium release in tracheal smooth-muscle cells.

  1999cited by this paper
• Microelectrode measurements of the effects of basolateral adenosine in polarized human intestinal epithelial cells in culture

  1999cited by this paper
• Distinct roles of JNKs/p38 MAP kinase and ERKs in apoptosis and survival of HCD-57 cells induced by withdrawal or addition of erythropoietin.

  1999cited by this paper
• Erythropoietin therapy in chronic uremia: the impact of normalization of hematocrit.

  1999cited by this paper
• SUBCUTANEOUS COMPARED WITH INTRAVENOUS EPOETIN IN PATIENTS RECEIVING HEMODIALYSIS

  1998cited by this paper
• Activation of protein kinase C in human hepatocellular carcinoma (HEP3B) cells increases erythropoietin production.

  1998cited by this paper
• Homodimerization Restores Biological Activity to an Inactive Erythropoietin Mutant*

  1998cited by this paper
• Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

  1998cited by this paper
• Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia.

  1998cited by this paper
• Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of theCBP/p300 coactivator by the hypoxia‐induciblefactor‐1α

  1998cited by this paper
• Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases.

  1998cited by this paper
• Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer*

  1998cited by this paper
• Subcutaneous compared with intravenous epoetin in patients receiving hemodialysis. Department of Veterans Affairs Cooperative Study Group on Erythropoietin in Hemodialysis Patients.

  1998cited by this paper
• NKF-DOQI clinical practice guidelines for the treatment of anemia of chronic renal failure. National Kidney Foundation-Dialysis Outcomes Quality Initiative.

  1997cited by this paper
• Post-transcriptional Regulation of Erythropoietin mRNA Stability by Erythropoietin mRNA-binding Protein*

  1997cited by this paper
• [Value of early management of patients with chronic renal failure].

  1997cited by this paper
• Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

  1997cited by this paper
• Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species.

  1997cited by this paper
• Erythropoietin Induces the Tyrosine Phosphorylation of Insulin Receptor Substrate-2

  1997cited by this paper
• Distinct Signaling from Stem Cell Factor and Erythropoietin in HCD57 Cells*

  1997cited by this paper
• Adenosine A2B receptors.

  1997cited by this paper
• Erythropoietin: Physiologic and Pharmacologic Aspects

  1997cited by this paper
• Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis.

  1996cited by this paper
• Erythropoietin‐induced erythroid differentiation of the human erythroleukemia cell line TF‐1 correlates with impaired STAT5 activation.

  1996cited by this paper
• A safety and efficacy comparison study of two dosing regimens of epoetin alfa in patients undergoing major orthopedic surgery.

  1996cited by this paper
• Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction.

  1996cited by this paper
• Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5.

  1996cited by this paper
• Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response

  1996cited by this paper
• The combination of erythropoietin and granulocyte colony‐stimulating factor increases the rate of haemopoietic recovery with clinical benefit after peripheral blood progenitor cell transplantation

  1996cited by this paper
• Erythropoietin treatment of erythropoietin-deficient anemia without renal disease during pregnancy.

  1996cited by this paper
• Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

  1996cited by this paper
• Consensus conference on autologous transfusion. Preoperative autologous donation

  1996cited by this paper
• Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1*

  1996cited by this paper
• Recombinant human erythropoietin enhances vasoconstrictor tone via endothelin-1 and constrictor prostanoids.

  1996cited by this paper
• Erythropoietin production by interstitial cells of hypoxic monkey kidneys

  1996cited by this paper
• Baseline hemoglobin as a predictor of risk of transfusion and response to Epoetin alfa in orthopedic surgery patients.

  1996cited by this paper
• The effect of recombinant human erythropoietin on the efficacy of autologous blood donation in patients with low hematocrits: a multicenter, randomized, double‐blind, controlled trial

  1996cited by this paper
• Role of nitric oxide resistance in erythropoietin-induced hypertension in rats with chronic renal failure.

  1996cited by this paper
• Decreased ferritin levels, despite iron supplementation, during erythropoietin therapy in anaemia of prematurity

  1996cited by this paper
• Oxford textbook of medicine

  1996cited by this paper
• Activation of protein kinase C increases adenosine production in the hypoxic canine coronary artery through the extracellular pathway.

  1995cited by this paper
• Cytokine receptor signalling

  1995cited by this paper
• Interaction of the erythropoietin and stem-cell-factor receptors

  1995cited by this paper
• The signal transduction pathway of erythropoietin involves three forms of mitogen-activated protein (MAP) kinase in UT7 erythroleukemia cells.

  1995cited by this paper
• Recombinant human erythropoietin stimulates angiogenesis in vitro.

  1995cited by this paper
• Erythropoietin gene expression in fetal and adult sheep kidney

  1995cited by this paper
• The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site.

  1995cited by this paper
• Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.

  1995cited by this paper

• Simvastatin and EPO in feline ovarian grafting: Distinct effects on cell and follicle survival.

  2026cites this paper
• Increased plasma levels of erythropoietin after renal denervation in patients with resistant hypertension

  2025cites this paper
• Overview of preclinical and phase II clinical studies on Pegmolesatide’s long-term erythropoiesis stimulating effect via EPOR-mediated signal transduction

  2025cites this paper
• The Recurrence of Venous Thromboembolism in Obstructive Sleep Apnea: A Narrative Review

  2025cites this paper
• Potential Association Between Darbepoetin Alfa Administration and Reduced Proteinuria in Real‐World Clinical Practice: A Post Hoc Analysis of the BRIGHTEN Study

  2025cites this paper
• Erythropoietin for Seizures and Epilepsy: Neuroprotective Effects, Mechanisms, and Contradictory Risks.

  2025cites this paper
• Erythropoietin promotes cell proliferation in Neuro-2A mouse neuroblastoma cells

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• In Vivo Study on 3D-Printed Polylactic Acid Nerve Tubes for Sciatic Nerve Injury Treatment

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• PHARMACOLOGICAL TRIGGERS OF SECONDARY ERYTHROCYTOSIS

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• Anemias in endocrine diseases

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• Advancing erythropoietin charge heterogeneity characterization by integrating ion exchange chromatography and imaged capillary isoelectric focusing coupled with online high-resolution mass spectrometry detection.

  2025cites this paper
• Morphology and Bioproduction Potential of DCB-Induced Cell Wall-Deficient Tobacco BY-2 Cells and Transcriptomic Analysis.

  2025cites this paper
• Erythropoietin Attenuates Insulin Resistance and Renal Inflammation in High-Sucrose-Treated Rats

  2025cites this paper
• Erythrocytosis and CKD.

  2024cites this paper
• Chronic Administration of Recombinant Human Erythropoietin Induces Angiogenesis in Healthy Mouse Brain

  2024cites this paper
• Hydrogen sulfide upregulates hypoxia inducible factors and erythropoietin production in chronic kidney disease induced by 5/6 nephrectomized rats

  2024cites this paper
• NGF, EPO, and IGF-1 in the Male Reproductive System

  2024cites this paper
• The role of erythropoietin in the treatment of ocular disorders: A literature review

  2024cites this paper
• Impact of Vitamin A Deficiency on Iron Metabolism and Anemia: A Historical Perspective and Research Advances.

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• Methanol Induced Optic Neuropathy: Molecular Mysteries, Public Health Perspective, Clinical Insights and Treatment Strategies

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• Erythropoietin-mediated IL-17 F attenuates sepsis-induced gut microbiota dysbiosis and barrier dysfunction.

  2023cites this paper
• Microdoses of Recombinant Human Erythropoietin Enhance Time Trial Performance in Trained Males and Females

  2022cites this paper
• Liquid chromatography-tandem mass spectrometry methods for quantification of roxadustat (FG-4592) in human plasma and urine and the applications in two clinical pharmacokinetic studies.

  2022cites this paper
• Erythropoietin administration exerted neuroprotective effects against cardiac ischemia/reperfusion injury

  2022cites this paper
• High yield secretion of human erythropoietin from tobacco cells for ex vivo differentiation of hematopoietic stem cells towards red blood cells.

  2022cites this paper
• Erythropoietin Enhances Post-ischemic Migration and Phagocytosis and Alleviates the Activation of Inflammasomes in Human Microglial Cells

  2022cites this paper
• Obstructive Sleep Apnea as a Risk Factor for Venous Thromboembolism: A Systematic Review

  2022cites this paper
• Erythropoietin as a Neuroprotective Drug for Newborn Infants: Ten Years after the First Use

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• Recombinant human erythropoietin and interferon-β-1b protect against 3-nitropropionic acid-induced neurotoxicity in rats: possible role of JAK/STAT signaling pathway

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• Adding erythropoietin to intravenous methylprednisolone in acute treatment of attacks of neuromyelitis optica spectrum disorders: A randomized controlled trial

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• The extracellular signal-regulated kinase 1/2 modulates the intracellular localization of DNA methyltransferase 3A to regulate erythrocytic differentiation.

  2020cites this paper
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• Proof-of-concept study on improved efficacy of rHuEPO administered as a long-term infusion in rats

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• [Characterisation of the protective role of erythropoetin in a murine model of acute lung injury].

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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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