Hormones and RNP granules – crosstalk in gene regulation across species

Hormones typically regulate physiology by modulating transcriptional programmes. However, post-transcriptional mechanisms offer an additional layer of control, enabling rapid and context-specific regulation of gene expression. Among these mechanisms, cytoplasmic ribonucleoprotein granules (RNPGs) – a type of membraneless condensate that includes stress granules and processing bodies – have emerged as dynamic regulators of RNA fate. These granules could serve as integrative hubs that modulate mRNA translation, stability and storage in response to endocrine signals, thereby fine-tuning hormone-driven cellular responses. This Hypothesis article proposes that hormonal cues can influence RNPG assembly, composition and physical state through transcriptional regulation of granule components or via rapid, non-genomic mechanisms, including kinase cascades or ligand-induced conformational changes in granule proteins. In turn, RNPGs can regulate hormone-driven cellular responses by selectively sequestering, releasing or degrading specific mRNAs. Furthermore, these granules can regulate hormonal pathways by controlling the availability of hormone-related transcripts and signalling components, establishing a bidirectional regulatory network. This dynamic interaction, illustrated by examples from plants, invertebrates and mammals, is hypothesised to add complexity and versatility to endocrine regulation, enabling rapid and adaptive responses to physiological demands.

• Publication year

  2025

• Venue

  Journal of Cell Science

• Publication date

  2025-11-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1242/jcs.264150
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• RNA m6A modification meets plant hormones

  2025cited by this paper
• Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B

  2025cited by this paper
• Drosophila and human Headcase define a new family of ribonucleotide granule proteins required for stress response

  2025cited by this paper
• G3BP1 Phosphorylation Regulates Plant Immunity in Arabidopsis

  2025cited by this paper
• Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells

  2025cited by this paper
• Lsm14b controls zebrafish oocyte growth by regulating polyadenylation of the mRNA poly(A) tail

  2024cited by this paper
• RNA sequestration in P-bodies sustains myeloid leukaemia

  2024cited by this paper
• Biomolecular condensates as stress sensors and modulators of bacterial signaling

  2024cited by this paper
• Emerging insights into transcriptional condensates

  2024cited by this paper
• The m6A reader ECT8 is an abiotic stress sensor that accelerates mRNA decay in Arabidopsis

  2024cited by this paper
• Salicylic acid (SA)-mediated plant immunity against biotic stresses: An insight on molecular components and signaling mechanism

  2024cited by this paper
• Plant RNA-binding proteins: phase-separation dynamics and functional mechanisms underlying plant development and stress responses.

  2024cited by this paper
• Androgen receptor interactions provide insight into steroid mediated metabolic shifts in endocrine resistant breast cancer

  2024cited by this paper
• Transcriptome-wide analysis for glucocorticoid receptor-mediated mRNA decay reveals various classes of target transcripts

  2024cited by this paper
• The RasGAP-associated endoribonuclease G3BP mediates stress granule assembly

  2023cited by this paper
• LSM14B coordinates protein component expression in the P-body and controls oocyte maturation.

  2023cited by this paper
• The proteome and transcriptome of stress granules and P bodies during human T lymphocyte activation.

  2023cited by this paper
• Post-Transcriptional and Epigenetic Regulation of Estrogen Signaling

  2023cited by this paper
• The m6A reader ECT1 drives mRNA sequestration to dampen salicylic acid-dependent stress responses in Arabidopsis.

  2023cited by this paper
• Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion

  2023cited by this paper
• Formation, function, and pathology of RNP granules.

  2023cited by this paper
• Phenolic acid-induced phase separation and translation inhibition mediate plant interspecific competition

  2023cited by this paper
• A guide to membraneless organelles and their various roles in gene regulation

  2022cited by this paper
• Dynamic phase separation of the androgen receptor and its coactivators key to regulate gene expression

  2022cited by this paper
• Composition and function of stress granules and P-bodies in plants.

  2022cited by this paper
• Novel roles for RNA binding proteins squid, hephaesteus, and Hrb27C in Drosophila oogenesis

  2022cited by this paper
• How Retinoic Acid and Arsenic Transformed Acute Promyelocytic Leukemia Therapy.

  2022cited by this paper
• Role of thyroid hormones-induced oxidative stress on cardiovascular physiology.

  2022cited by this paper
• TRIM24 is an insulin-responsive regulator of P-bodies

  2022cited by this paper
• mRNAs sequestered in stress granules recover nearly completely for translation

  2022cited by this paper
• Glucocorticoids enhance chemotherapy-driven stress granule assembly and impair granule dynamics, leading to cell death

  2022cited by this paper
• The androgen receptor messenger RNA: what do we know?

  2022cited by this paper
• Ethylene modulates translation dynamics in Arabidopsis under submergence via GCN2 and EIN2

  2022cited by this paper
• OUP accepted manuscript

  2022cited by this paper
• microRNA-34 Family: From Mechanism to Potential Applications.

  2022cited by this paper
• Systemic and local effect of the Drosophila headcase gene and its role in stress protection of Adult Progenitor Cells

  2021cited by this paper
• Dihydrocapsaicin induces translational repression and stress granule through HRI-eIF2α phosphorylation axis.

  2021cited by this paper
• The emerging role of biomolecular condensates in plant immunity.

  2021cited by this paper
• ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance.

  2021cited by this paper
• Role of Liquid–Liquid Separation in Endocrine and Living Cells

  2021cited by this paper
• Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner

  2021cited by this paper
• Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability

  2021cited by this paper
• Connecting the "dots": RNP granule network in health and disease.

  2021cited by this paper
• Arabidopsis N6-methyladenosine reader CPSF30-L recognizes FUE signal to control polyadenylation site choice in liquid-like nuclear body.

  2021cited by this paper
• Estrogen‐Induced hsa‐miR‐10b‐5p Is Elevated in T Cells From Patients With Systemic Lupus Erythematosus and Down‐Regulates Serine/Arginine‐Rich Splicing Factor 1

  2021cited by this paper
• G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

  2021cited by this paper
• Redox regulation of the insulin signalling pathway

  2021cited by this paper
• Phase Separation during Germline Development.

  2021cited by this paper
• Hsp90‐mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling

  2021cited by this paper
• The regulation of RNA metabolism in hormone signaling and breast cancer.

  2021cited by this paper
• Insulin directly stimulates mitochondrial glucose oxidation in the heart

  2020cited by this paper
• Modulation of RNA Condensation by the DEAD-Box Protein eIF4A.

  2020cited by this paper
• Single-molecule imaging reveals translation of mRNAs localized to stress granules

  2020cited by this paper
• RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

  2020cited by this paper
• Molecular mechanisms of stress granule assembly and disassembly.

  2020cited by this paper
• G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.

  2020cited by this paper
• The nucleolus as a multiphase liquid condensate

  2020cited by this paper
• Phase‐separated bacterial ribonucleoprotein bodies organize mRNA decay

  2020cited by this paper
• Mammalian stress granules and P bodies at a glance

  2020cited by this paper
• Granule regulation by phase separation during Drosophila oogenesis

  2020cited by this paper
• The Diverse Functions of IMP2/IGF2BP2 in Metabolism.

  2020cited by this paper
• Properties of Stress Granule and P-Body Proteomes.

  2019cited by this paper
• Headcase and Unkempt Regulate Tissue Growth and Cell Cycle Progression in Response to Nutrient Restriction

  2019cited by this paper
• The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner

  2019cited by this paper
• UBAP2L arginine methylation by PRMT1 modulates stress granule assembly

  2019cited by this paper
• Overexpression of Lin28a delays Xenopus metamorphosis and down‐regulates albumin independently of its translational regulation domain

  2019cited by this paper
• SnRK2 Protein Kinases and mRNA Decapping Machinery Control Root Development and Response to Salt1[OPEN]

  2019cited by this paper
• PML nuclear bodies: from architecture to function.

  2018cited by this paper
• Friend or foe—Post-translational modifications as regulators of phase separation and RNP granule dynamics

  2018cited by this paper
• Coactivator condensation at super-enhancers links phase separation and gene control

  2018cited by this paper
• P-Bodies: Composition, Properties, and Functions

  2018cited by this paper
• Noncanonical Translation Initiation in Eukaryotes.

  2018cited by this paper
• The translational regulation of maternal mRNAs in time and space

  2018cited by this paper
• The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity

  2018cited by this paper
• A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response

  2017cited by this paper
• Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging

  2017cited by this paper
• The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer.

  2017cited by this paper
• CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses

  2017cited by this paper
• ABA-unresponsive SnRK2 protein kinases regulate mRNA decay under osmotic stress in plants

  2017cited by this paper
• G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-κB signaling pathway

  2017cited by this paper
• Role of G3BP1 in glucocorticoid receptor-mediated microRNA-15b and microRNA-23a biogenesis in endothelial cells

  2017cited by this paper
• Biomolecular condensates: organizers of cellular biochemistry

  2017cited by this paper
• The heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone function.

  2017cited by this paper
• AMP Kinase Activation Alters Oxidant-Induced Stress Granule Assembly by Modulating Cell Signaling and Microtubule Organization

  2016cited by this paper
• miR-34 Modulates Innate Immunity and Ecdysone Signaling in Drosophila

  2016cited by this paper
• A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis

  2016cited by this paper
• YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

  2015cited by this paper
• EIN2-directed translational regulation of ethylene signaling in Arabidopsis.

  2015cited by this paper
• Genetic analysis of zebrafish gonadotropin (FSH and LH) functions by TALEN-mediated gene disruption.

  2015cited by this paper
• Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2.

  2015cited by this paper
• Glucocorticoid receptor interacts with PNRC2 in a ligand-dependent manner to recruit UPF1 for rapid mRNA degradation

  2015cited by this paper
• Tristetraprolin is involved in the glucocorticoid-mediated interleukin 8 repression.

  2014cited by this paper
• From Oocyte to Fertilizable Egg

  2014cited by this paper
• Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)

  2014cited by this paper
• Coordinated Post-Transcriptional Regulation of the Chemokine System: Messages from CCL2

  2014cited by this paper
• The RNA-binding protein Y14 inhibits mRNA decapping and modulates processing body formation

  2013cited by this paper
• Non-Genomic Estrogen Regulation of Ion Transport and Airway Surface Liquid Dynamics in Cystic Fibrosis Bronchial Epithelium

  2013cited by this paper
• mTORC1 regulates the efficiency and cellular capacity for protein synthesis.

  2013cited by this paper
• The Arabidopsis tandem CCCH zinc finger proteins AtTZF4, 5 and 6 are involved in light-, abscisic acid- and gibberellic acid-mediated regulation of seed germination.

  2013cited by this paper
• Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies.

  2013cited by this paper

• No citing papers are available for this paper.