Multivalently engineered glyco-nanoplatforms for targeted therapy and diagnostics

Glyco-nanoplatforms have emerged as powerful nanosystems that exploit glycan–lectin interactions for targeted therapy, diagnostics, and immunomodulation. By presenting glycans in multivalent architectures, glyco-nanoplatforms enhance binding affinity and specificity toward glycan-recognizing receptors on mammalian and bacterial cells. This perspective highlights recent advances in the design and synthesis of glyco-nanoplatforms across four key classes, including glyco-gold nanoparticles, glycopolymer-based nanoplatforms, glyco-functionalized quantum dots, and glycan-based magnetic nanocomposites. Through diverse synthetic strategies, structurally distinct glyco-nanoplatforms have been developed with improved binding affinities, stability, and biodistribution. Moreover, we further discuss their diverse biomedical applications in both mammalian and bacterial cells, ranging from targeted cancer therapy and biosensing to immunomodulation and antimicrobial treatment. Finally, we outline key challenges and provide an outlook on further directions in this field, aiming to unlock the therapeutic potential of the glyco-code.

• Publication year

  2025

• Venue

  Chemical Science

• Publication date

  2025-11-10

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1039/d5sc05780aPMID 41245763PMCID 12614179
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Combination of mannoside and phenylboronic acid polycaprolactone polymers for doxorubicin-encapsulated polymersome nanomedicine targeting MDA-MB-231 cancer cells

  2025cited by this paper
• All-in-one multifunctional tri-block glycopolymers for targeted delivery of cisplatin and cancer chemotherapy.

  2025cited by this paper
• Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles

  2025cited by this paper
• Solid Lipid Nanoparticles Coated with Glucosylated poly(2-oxazoline)s: A Supramolecular Toolbox Approach

  2025cited by this paper
• Gold nanoparticles functionalized with ABO blood sugar antigen as nanotools for biomedical applications.

  2025cited by this paper
• Glyco-nanomaterials as a therapeutic target in drug delivery and biomedicine: A review.

  2025cited by this paper
• Enhancing cancer immunotherapy with mannose mimicking glycopolymer nanoparticles induced activation of Dendritic cells.

  2024cited by this paper
• Integrating Metabolic Oligosaccharide Engineering and SPAAC Click Chemistry for Constructing Fibrinolytic Cell Surfaces.

  2024cited by this paper
• Highly Sensitive Spatial Glycomics at Near-Cellular Resolution by On-Slide Derivatization and Mass Spectrometry Imaging

  2024cited by this paper
• Glycosylated stimuli responsive polyacrylamide microspheres with in-situ formed AgNPs for bacterial capture, detection and killing

  2024cited by this paper
• Active Targeting Hyaluronan Conjugated Nanoprobe for Magnetic Particle Imaging and Near-Infrared Fluorescence Imaging of Breast Cancer and Lung Metastasis

  2024cited by this paper
• Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms

  2024cited by this paper
• Donor Preactivation-Based Glycan Assembly: from Manual to Automated Synthesis.

  2024cited by this paper
• Exploring glycans as vital biological macromolecules: A comprehensive review of advancements in biomedical frontiers.

  2024cited by this paper
• Multinozzle Emitter for Improved Negative Mode Analysis of Reduced Native N-Glycans by Microflow Porous Graphitized Carbon Liquid Chromatography Mass Spectrometry

  2024cited by this paper
• Robust Synthesis of Targeting Glyco‐Nanoparticles for Surface Enhanced Resonance Raman Based Image‐Guided Tumor Surgery

  2024cited by this paper
• Glucose Functionalized Magnetic Iron Oxide Nanoparticles for Protein Detection and Separation

  2024cited by this paper
• Review of Advances in Coating and Functionalization of Gold Nanoparticles: From Theory to Biomedical Application

  2024cited by this paper
• Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery

  2024cited by this paper
• Inhibition of iRhom1 by CD44-targeting nanocarrier for improved cancer immunochemotherapy

  2024cited by this paper
• CRISPR screens and lectin microarrays identify high mannose N-glycan regulators

  2024cited by this paper
• Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma

  2024cited by this paper
• Recent advances in surface decoration of nanoparticles in drug delivery

  2024cited by this paper
• Polyvalent Glycomimetic-Gold Nanoparticles Revealing Critical Roles of Glycan Display on Multivalent Lectin–Glycan Interaction Biophysics and Antiviral Properties

  2024cited by this paper
• A Review of Biomimetic and Biodegradable Magnetic Scaffolds for Bone Tissue Engineering and Oncology

  2023cited by this paper
• Silver telluride colloidal quantum dot infrared photodetectors and image sensors

  2023cited by this paper
• Enabling Chemoenzymatic Strategies and Enzymes for Synthesizing Sialyl Glycans and Sialyl Glycoconjugates

  2023cited by this paper
• Rapid Isolation of Low-Level Carbapenem-Resistant E. coli from Water and Foods Using Glycan-Coated Magnetic Nanoparticles

  2023cited by this paper
• Glycopolymer-grafted nanoparticles as glycosaminoglycan mimics with cell proliferation and anti-tumor metastasis activities.

  2023cited by this paper
• Synthesis of magnetic chitosan/hyaluronic acid/κ-carrageenan nanocarriers for drug delivery.

  2023cited by this paper
• Programmable Monodisperse Glyco-Multivalency Using Self-Assembled Coordination Cages as Scaffolds

  2023cited by this paper
• Establishing mammalian GLUT kinetics and lipid composition influences in a reconstituted-liposome system

  2023cited by this paper
• A Label-Free Carbohydrate-Based Electrochemical Sensor to Detect Escherichia coli Pathogenic Bacteria Using D-mannose on a Glassy Carbon Electrode

  2023cited by this paper
• Chitosan based sorafenib tosylate loaded magnetic nanoparticles: Formulation and in-vitro characterization.

  2023cited by this paper
• Green synthesis of glyco-CuInS2 QDs with visible/NIR dual emission for 3D multicellular tumor spheroid and in vivo imaging

  2023cited by this paper
• Highly-sensitive label-free deep profiling of N-glycans released from biomedically-relevant samples

  2023cited by this paper
• Polyvalent Glycan Functionalized Quantum Nanorods as Mechanistic Probes for Shape-Selective Multivalent Lectin-Glycan Recognition

  2023cited by this paper
• Magnetic nanoparticle embedded chitosan-based polymeric network for the hydrophobic drug delivery of paclitaxel.

  2023cited by this paper
• Turning on the Antimicrobial Activity of Gold Nanoclusters Against Multidrug-resistant Bacteria.

  2023cited by this paper
• Importance of GLUT Transporters in Disease Diagnosis and Treatment

  2022cited by this paper
• Recent advances in synthetic glycoengineering for biological applications.

  2022cited by this paper
• Tween 80 Improves the Acid-Fast Bacilli Quantification in the Magnetic Nanoparticle-Based Colorimetric Biosensing Assay (NCBA)

  2022cited by this paper
• Bacterial identification and adhesive strength evaluation based on a mannose biosensor with dual-mode detection.

  2022cited by this paper
• Angiogenic Hyaluronic Acid Hydrogels with Curcumin-Coated Magnetic Nanoparticles for Tissue Repair.

  2022cited by this paper
• Molecularly imprinted polymers outperform lectin counterparts and enable more precise cancer diagnosis

  2022cited by this paper
• Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates

  2022cited by this paper
• CD44-Targeted Nanocarrier for Cancer Therapy

  2022cited by this paper
• Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects.

  2022cited by this paper
• The Shape of Nanostructures Encodes Immunomodulation of Carbohydrate Antigen and Vaccine Development.

  2022cited by this paper
• Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop N-glycan modulators as anticancer agents

  2022cited by this paper
• Biocompatible Nanoparticles Based on Amphiphilic Random Polypeptides and Glycopolymers as Drug Delivery Systems

  2022cited by this paper
• Nanococktail Based on Supramolecular Glyco-Assembly for Eradicating Tumors In Vivo.

  2022cited by this paper
• Starch-Coated Magnetic Iron Oxide Nanoparticles for Affinity Purification of Recombinant Proteins

  2022cited by this paper
• Polyaniline-Based Glyco-Condensation on Au Nanoparticles Enhances Immunotherapy in Lung Cancer.

  2022cited by this paper
• Reading the glyco-code: New approaches to studying protein–carbohydrate interactions

  2022cited by this paper
• Host-directed immunotherapy of viral and bacterial infections: past, present and future

  2022cited by this paper
• Glycopolymers for Drug Delivery: Opportunities and Challenges

  2022cited by this paper
• Pharmacokinetics of magnetic iron oxide nanoparticles for medical applications

  2022cited by this paper
• Immunotherapy: an alternative promising therapeutic approach against cancers

  2022cited by this paper
• Mannose modified co-loaded zoledronic liposomes deplete M2-tumor-associated macrophages to enhance anti-tumor effect of doxorubicin on TNBC

  2022cited by this paper
• Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

  2022cited by this paper
• Polymer-tethered glycosylated gold nanoparticles recruit sialylated glycoproteins into their protein corona, leading to off-target lectin binding

  2022cited by this paper
• Clinical translation of gold nanoparticles

  2022cited by this paper
• Novel approaches to design glycan‐based antibacterial inhibitors

  2022cited by this paper
• Clinical cancer immunotherapy: Current progress and prospects

  2022cited by this paper
• Smart and Multi-Functional Magnetic Nanoparticles for Cancer Treatment Applications: Clinical Challenges and Future Prospects

  2022cited by this paper
• Photo‐Induced Microfluidic Production of Ultrasmall Glyco Gold Nanoparticles

  2022cited by this paper
• Sugar-decorated carbon dots: a novel tool for targeting immunomodulatory receptors

  2022cited by this paper
• Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes

  2022cited by this paper
• Glycobiology of cellular expiry: Decrypting the role of glycan-lectin regulatory complex and therapeutic strategies focusing on cancer.

  2022cited by this paper
• Multivalent glycosystems for human lectins.

  2022cited by this paper
• Lactose-containing glycopolymer grafted onto magnetic titanium dioxide nanomaterials for targeted capture and photocatalytic killing of pathogenic bacteria

  2021cited by this paper
• Tumor-associated macrophages of the M1/M2 phenotype are involved in the regulation of malignant biological behavior of breast cancer cells through the EMT pathway

  2021cited by this paper
• Dynamic Glycopeptide Dendrimers: Synthesis and Their Controllable Self-Assembly into Varied Glyco-Nanostructures for the Biomimicry of Glycans.

  2021cited by this paper
• Glyco-Coated CdSe/ZnS Quantum Dots as Nanoprobes for Carbonic Anhydrase IX Imaging in Cancer Cells

  2021cited by this paper
• Glycan-Based Flow-Through Device for the Detection of SARS-COV-2

  2021cited by this paper
• The state of CD44 activation in cancer progression and therapeutic targeting

  2021cited by this paper
• Carbohydrate-Based Macromolecular Biomaterials.

  2021cited by this paper
• Current hurdles to the translation of nanomedicines from bench to the clinic

  2021cited by this paper
• The role of CD44 in cancer chemoresistance: a concise review.

  2021cited by this paper
• Construction of Highly Ordered Glyco‐Inside Nano‐Assemblies through RAFT Dispersion Polymerization of Galactose‐Decorated Monomer

  2021cited by this paper
• Exosome-mediated diagnosis of pancreatic cancer using lectin-conjugated nanoparticles bound to selective glycans.

  2021cited by this paper
• Dual pathway for promotion of stem cell neural differentiation mediated by gold nanocomposites.

  2020cited by this paper
• Precisely Regulated Luminescent Gold Nanoparticles for Identification of Cancer Metastases.

  2020cited by this paper
• Glycoprotein- and Lectin-Based Approaches for Detection of Pathogens

  2020cited by this paper
• Microfluidic Synthesis of Hybrid TiO2-Anisotropic Gold Nanoparticles with Visible and Near-Infrared activity.

  2020cited by this paper
• Magnetic nanoparticles coated with carbohydrates for 3D culture of bacteria.

  2020cited by this paper
• Nanovesicles displaying functional linear and branched oligomannose self-assembled from sequence-defined Janus glycodendrimers

  2020cited by this paper
• Macrophage Activation Markers, CD163 and CD206, in Acute-on-Chronic Liver Failure

  2020cited by this paper
• Multifunctional Glyco‐Nanosheets to Eradicate Drug‐Resistant Bacteria on Wounds

  2020cited by this paper
• Smart Glycopolymeric Nanoparticles for Multivalent Lectin Binding and Stimuli-Controlled Guest Release.

  2020cited by this paper
• Targeting and Inhibiting Plasmodium falciparum Using Ultra-small Gold Nanoparticles

  2020cited by this paper
• Activating Antibacterial Effect of 4,6-diamino-2-pyrimidinethiol-modified Gold Nanoparticles by Reducing their Sizes.

  2020cited by this paper
• Mannose-functionalized antigen nanoparticles for targeted dendritic cells, accelerated endosomal escape and enhanced MHC-I antigen presentation.

  2020cited by this paper
• An on-demand nanoplatform for enhanced elimination of drug-resistant bacteria.

  2020cited by this paper
• Fluorescent Carbon Dots Functionalized with Self-Assembled Glycan Monolayers for Probing Interactions across the Glyco-Interactome

  2020cited by this paper
• Recent advances in immunotherapies against infectious diseases

  2020cited by this paper
• Protein corona, understanding the nanoparticle-protein interactions and future perspectives: A critical review.

  2020cited by this paper
• Carbon Dots: A New Type of Carbon-Based Nanomaterial with Wide Applications

  2020cited by this paper
• A GSH-Responsive Nanoprodrug System Based on Self-Assembly of Lactose Modified Camptothecin for Targeted Drug Delivery and Combination Chemotherapy

  2020cited by this paper

• No citing papers are available for this paper.