Stress-Induced Dysregulation of Brain Iron Metabolism and Its Links to Neurological Disorders

Simple Summary Iron is an essential trace element whose homeostasis is critical for normal nervous system function. Increasing evidence indicates that stress perturbs iron metabolism and thereby contributes to the onset and progression of a spectrum of neurological diseases. Here, we synthesize the current knowledge of how iron levels change under stress, how those alterations reshape brain function, and the underlying molecular mechanisms. We focus on abnormal cerebral iron accumulation during stress and routes for iron entry across the blood–brain barrier. We further discuss the therapeutic potential of iron chelators and explore the three-way relationship among stress, iron metabolism, and neurological disease.

• Publication year

  2025

• Venue

  Biology

• Publication date

  2025-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/biology14111575PMID 41300365PMCID 12650124
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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