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Revolutionizing Wound Care: The Role of Nanotechnology and Biopolymer-Based Materials.

Prajakta A Mane,Rahul M Sonavale,R. Phatak,N. Shukla,Zhengyou Li,O. Polozhentsev,Carol Y. Cárdenas,S. Belbekhouche

Published 2025 in ACS Applied Bio Materials

ABSTRACT

Wound infections represent a significant global healthcare burden, often complicating healing processes and leading to increased morbidity. These infections vary in type, ranging from acute to chronic, surgical site infections, and pressure ulcers, each presenting distinct pathological and microbiological profiles. The primary causative agents include Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes as well as Gram-negative pathogens such as Pseudomonas aeruginosa and Escherichia coli. Conventional treatment modalities largely rely on systemic or topical antibiotics, debridement of the wound, and antiseptics. However, rising antimicrobial resistance, slow tissue regeneration, and recurrent infections limit the efficacy of these approaches. Recent advances in nanotechnology- and biopolymer-based materials have enhanced wound care options. Biopolymers such as chitosan, alginate, and collagen are valued for their biocompatibility and biodegradability. Chitosan uniquely offers inherent antimicrobial activity, while collagen, alginate, and agarose mainly function as biocompatible scaffolds or drug delivery systems without significant antibacterial properties. When combined with metal nanoparticles, particularly silver, zinc oxide, and gold, these composites exhibit enhanced antibacterial activity, anti-inflammatory effects, and improved wound healing dynamics. Such nanocomposites can be engineered into films, hydrogels, and scaffolds that facilitate moisture retention, controlled drug release, and tissue regeneration, while minimizing cytotoxicity. The integration of nanotechnology with biopolymer science represents a paradigm shift in wound management strategies. This multidisciplinary approach not only addresses the limitations of conventional therapies but also offers tailored, responsive, and effective wound healing platforms. Continued research into the synergistic effects of nanoparticles and natural polymers is essential to fully realize their clinical potential. Ultimately, these innovations could transform wound care, offering patients faster recovery, reduced infection rates, and an improved quality of life. Additionally, hybrid nanocomposites such as hydroxyapatite-based systems have shown enhanced bioactive properties.

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