Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Journal of Virology

• Publication date

  1996-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/jvi.70.8.4953-4960.1996PMID 8764000PMCID PMC190447
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1995influential reference
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  1995influential reference
• Unique cytokine production profile of anergic human T cells in SCID-hu mice after staphylococcal enterotoxin B administration.

  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1984cited by this paper
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  1984cited by this paper

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