Structural Analysis of Spatial Dendritic Spines Distribution Patterns in Norm and Alzheimer’s Disease Pathology

Dendritic spines are crucial for synaptic plasticity, learning and memory, and their spatial organization influences neuronal network efficiency. However, the patterns of their distribution in normal and in neurodegenerative conditions such as Alzheimer’s disease (AD) remain unclear. In this study, we analyzed the location of spines on dendrites in wild-type (Wt) and AD model hippocampal neurons exposed to low levels of beta-amyloid (Ab) toxicity. Spatial clustering methods such as mean distance to nearest neighbor, pairwise correlation function and Moran’s index were used to evaluate grouping, and spatial clustering and spine neighborhoods were also analyzed. The results showed differences in spine density, their mutual distances and clustering between WT and Aβ dendrites, indicating a change in spatial organization during neurodegeneration. The developed methodology allows us to quantify spine clustering and obtain a set of dendrite features, including a probability matrix of spatial arrangement of spines with different morphological features. The results of the analysis demonstrated that there are exact differences in the structure of Ab and Wt dendrites. In addition, a correlation between the morphological features of the spines and their relative position was found.

• Publication year

  2025

• Venue

  2025 Systems and Technologies of the Digital HealthCare (STDH)

• Publication date

  2025-06-02

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1109/STDH66836.2025.11227459
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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