Structural basis of long-term potentiation in single dendritic spines

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature

• Publication date

  2004-06-17

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nature02617PMID 15190253PMCID PMC4158816
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1995cited by this paper
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  1992cited by this paper
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  1973cited by this paper
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  1937cited by this paper
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  year unknowncited by this paper

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