Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Hippocampus

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/HIPO.10130PMID 14750653
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome.

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  2002influential reference
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  2002influential reference
• Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

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• Going new places using an old MAP: tau, microtubules and human neurodegenerative disease.

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• Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function.

  2001influential reference
• Motor learning in Ts65Dn mice, a model for Down syndrome.

  2001influential reference
• Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.

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  1999influential reference
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  1998cited by this paper
• Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice.

  1998influential reference
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  1998cited by this paper
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  1998influential reference
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  1998cited by this paper
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  1997cited by this paper
• The cholinergic system in Alzheimer's disease.

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  1992cited by this paper
• Alzheimer Lesions in the Entorhinal Region and Isocortex in Parkinson's and Alzheimer's Diseases a

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  1990cited by this paper
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• Abnormalities of the nucleus basalis in Down's syndrome

  1985cited by this paper
• Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

  1985cited by this paper
• Alzheimer-like cholinergic deficiency in Down syndrome.

  1980cited by this paper
• Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.

  1978cited by this paper
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• PRELIMINARY CHARACTERIZATION

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