Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein.

We have investigated the possible effect of estrogen on the metabolism of the Alzheimer amyloid precursor protein (APP). Using a cell line that contains high levels of estrogen receptors, we have found that treatment with physiological concentrations of 17 beta-estradiol is associated with accumulation in the conditioned medium of an amino-terminal cleavage product of APP (soluble APP or protease nexin-2), indicative of non-amyloidogenic processing. There were no obvious changes in the levels of intracellular immature or mature APP holoproteins, suggesting that estrogen may increase the secretory metabolism of APP.

• Publication year

  1994

• Venue

  Journal of Biological Chemistry

• Publication date

  1994-05-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0021-9258(17)36796-0PMID 8175728
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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