Insights into the Multifaceted Roles and Pleiotropic Functions of ALDH1L2 with Implications in Gastrointestinal Diseases and Cancer

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Current Genetic Medicine Reports

• Publication date

  2025-11-27

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1007/s40142-025-00227-0
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• ALDH1L2 drives HCC progression through TAM polarization

  2024cited by this paper
• Aldehyde dehydrogenase in solid tumors and other diseases: Potential biomarkers and therapeutic targets

  2023cited by this paper
• Pyridoxine-dependent epilepsy: Current perspectives and questions for future research

  2023cited by this paper
• Identifying the Molecular Drivers of Pathogenic Aldehyde Dehydrogenase Missense Mutations in Cancer and Non-Cancer Diseases

  2023cited by this paper
• ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis.

  2023influential reference
• Evaluation and analysis of novel germline variants in ethanol metabolism pathway genes predisposition to liver disease.

  2023cited by this paper
• Acetaldehyde Dehydrogenases in Liver Zonation and Liver Cancer

  2023cited by this paper
• Cellular Adaptation Takes Advantage of Atavistic Regression Programs during Carcinogenesis

  2023cited by this paper
• Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular redox balance and the chemosensitivity of colorectal cancer to 5-fluorouracil

  2023cited by this paper
• TXN inhibitor impedes radioresistance of colorectal cancer cells with decreased ALDH1L2 expression via TXN/NF-κB signaling pathway

  2022cited by this paper
• Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol‐related disorder and cancer

  2022cited by this paper
• ALDH1L2 Knockout in U251 Glioblastoma Cells Reduces Tumor Sphere Formation by Increasing Oxidative Stress and Suppressing Methionine Dependency

  2022cited by this paper
• Mitochondrial Dysfunction and Chronic Liver Disease

  2022cited by this paper
• Comprehensive Analysis of Aldehyde Dehydrogenases (ALDHs) and Its Significant Role in Hepatocellular Carcinoma

  2021cited by this paper
• Insights into Aldehyde Dehydrogenase Enzymes: A Structural Perspective

  2021cited by this paper
• Reactive oxygen species in cancer: Current findings and future directions

  2021cited by this paper
• Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD)

  2021cited by this paper
• Associations between ALDH Genetic Variants, Alcohol Consumption, and the Risk of Nasopharyngeal Carcinoma in an East Asian Population

  2021cited by this paper
• Alcohol associated liver cirrhotics have higher mortality after index hospitalization: Long-term data of 5,138 patients

  2020influential reference
• Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

  2020influential reference
• The Roles of Mitochondrial Folate Metabolism in Supporting Mitochondrial DNA Synthesis, Oxidative Phosphorylation, and Cellular Function

  2020cited by this paper
• Survey of Addiction Specialists’ Use of Medications to Treat Alcohol Use Disorder

  2020cited by this paper
• Alcohol-Associated Liver Disease

  2020cited by this paper
• Deleterious mutations in ALDH1L2 suggest a novel cause for neuro-ichthyotic syndrome

  2019cited by this paper
• Aldehyde Dehydrogenase Inhibitors for Cancer Therapeutics.

  2019cited by this paper
• ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA enriched extracellular vesicles.

  2019cited by this paper
• Alcoholic Liver Disease: Alcohol Metabolism, Cascade of Molecular Mechanisms, Cellular Targets, and Clinical Aspects

  2018cited by this paper
• Toward a better understanding of folate metabolism in health and disease

  2018cited by this paper
• The mitochondrial one-carbon metabolic pathway is associated with patient survival in pancreatic cancer.

  2018cited by this paper
• Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis

  2018cited by this paper
• Deletion of the neural tube defect–associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos

  2018cited by this paper
• ALDH1L1 and ALDH1L2 Folate Regulatory Enzymes in Cancer.

  2018cited by this paper
• Association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer

  2017cited by this paper
• ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective

  2017cited by this paper
• The importance of mitochondrial folate enzymes in human colorectal cancer.

  2017cited by this paper
• Pan-cancer analysis of whole genomes

  2017cited by this paper
• One-Carbon Metabolism in Health and Disease.

  2017cited by this paper
• Neonatal hydrocephalus is a result of a block in folate handling and metabolism involving 10‐formyltetrahydrofolate dehydrogenase

  2016cited by this paper
• Serine and one-carbon metabolism in cancer

  2016cited by this paper
• Treatment of alcohol use disorders in patients with alcoholic liver disease.

  2016cited by this paper
• Cancer stem cell markers in prostate cancer: an immunohistochemical study of ALDH1, SOX2 and EZH2

  2015cited by this paper
• Oxidative stress inhibits distant metastasis by human melanoma cells

  2015cited by this paper
• RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics

  2015cited by this paper
• Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A1.

  2015cited by this paper
• The Epidemiology of Cirrhosis in the United States: A Population-based Study

  2015influential reference
• Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.

  2015cited by this paper
• Cancer stem cells in progression of colorectal cancer

  2015cited by this paper
• Molecular Mechanisms of Aldehyde Toxicity: A Chemical Perspective

  2014cited by this paper
• Expression of ALDH1 and TGFβ2 in benign and malignant breast tumors and their prognostic implications.

  2014cited by this paper
• Folate: metabolism, genes, polymorphisms and the associated diseases.

  2014cited by this paper
• ALDH‐1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients

  2014cited by this paper
• Dominance of the inactive Asian variant over activity and protein contents of mitochondrial aldehyde dehydrogenase 2 in human liver.

  2014cited by this paper
• Quantitative flux analysis reveals folate-dependent NADPH production

  2014cited by this paper
• ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway

  2013cited by this paper
• Aldehyde Dehydrogenase Inhibitors: a Comprehensive Review of the Pharmacology, Mechanism of Action, Substrate Specificity, and Clinical Application

  2012cited by this paper
• ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets

  2012cited by this paper
• EASL clinical practical guidelines: management of alcoholic liver disease.

  2012cited by this paper
• 3-Hydroxyisobutyrate aciduria and mutations in the ALDH6A1 gene coding for methylmalonate semialdehyde dehydrogenase

  2012cited by this paper
• Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate's role.

  2012cited by this paper
• Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase.

  2011cited by this paper
• Phylogeny and evolution of aldehyde dehydrogenase-homologous folate enzymes.

  2011cited by this paper
• Update on the aldehyde dehydrogenase gene (ALDH) superfamily

  2011influential reference
• Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis

  2011cited by this paper
• Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform

  2011cited by this paper
• Acetaldehyde and gastric cancer

  2011cited by this paper
• ALDH1L2 Is the Mitochondrial Homolog of 10-Formyltetrahydrofolate Dehydrogenase*

  2010influential reference
• FDH: an aldehyde dehydrogenase fusion enzyme in folate metabolism.

  2009cited by this paper
• ALDH1A1 and ALDH3A1 expression in lung cancers: correlation with histologic type and potential precursors.

  2008cited by this paper
• Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

  2008cited by this paper
• Multiple and Additive Functions of ALDH3A1 and ALDH1A1

  2007cited by this paper
• The Status of Disulfiram: A Half of a Century Later

  2006cited by this paper
• Mitochondrial metabolism of reactive oxygen species

  2005cited by this paper
• Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family

  2005cited by this paper
• Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.

  2004cited by this paper
• Pre-mRNA splicing and human disease.

  2003cited by this paper
• Human aldehyde dehydrogenases: Potential pathological, pharmacological, and toxicological impact

  2003cited by this paper
• Aldehyde dehydrogenase gene superfamily: the 2002 update.

  2003cited by this paper
• Comparison of cyanamide and disulfiram in effects on liver function.

  2000cited by this paper
• Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping.

  1999cited by this paper
• Human aldehyde dehydrogenase gene family.

  1998cited by this paper
• Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters.

  1997cited by this paper
• Inter-individual and intra-individual variability of ethanol concentration-time profiles: comparison of ethanol ingestion before or after an evening meal.

  1995cited by this paper
• 8 Congenital errors of folate metabolism

  1995cited by this paper
• Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study.

  1986cited by this paper
• Respiratory tract tumours in hamsters exposed to acetaldehyde vapour alone or simultaneously to benzo(a)pyrene or diethylnitrosamine.

  1982cited by this paper
• Oncotargets and Therapy Dovepress Dovepress Prognostic Values of Aldehyde Dehydrogenase 1 Isoenzymes in Ovarian Cancer

  year unknowncited by this paper

• No citing papers are available for this paper.