Architectural Transcription Factor HMGI(Y) Promotes Tumor Progression and Mesenchymal Transition of Human Epithelial Cells

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Molecular and Cellular Biology

• Publication date

  2001-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.21.2.575-594.2001PMID 11134344PMCID PMC86623
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer

  2005cited by this paper
• Matrix degrading metalloproteinases

  2005cited by this paper
• Epithelial Cell Plasticity in Development and Tumor Progression

  2004cited by this paper
• Differentiation state and invasiveness of human breast cancer cell lines

  2004cited by this paper
• Differential in vivo modifications of the HMGI(Y) nonhistone chromatin proteins modulate nucleosome and DNA interactions.

  2000cited by this paper
• HMG-I/Y, a New c-Myc Target Gene and Potential Oncogene

  2000cited by this paper
• Genomic structure and expression of the murine Hmgi(y) gene.

  2000cited by this paper
• Genomic analysis of metastasis reveals an essential role for RhoC

  2000cited by this paper
• Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

  2000cited by this paper
• The oncogenic properties of the HMG-I gene family.

  2000cited by this paper
• Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias.

  2000cited by this paper
• Structure and function of the HMGI(Y) family of architectural transcription factors.

  2000cited by this paper
• The Role of High-Mobility Group I(Y) Proteins in Expression of IL-2 and T Cell Proliferation1

  2000cited by this paper
• Molecular portraits of human breast tumours

  2000influential reference
• alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression.

  1999cited by this paper
• Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling.

  1999cited by this paper
• Membrane associated matrix metalloproteinases in metastasis.

  1999influential reference
• In vivo gene expression profile analysis of human breast cancer progression.

  1999cited by this paper
• Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast.

  1999cited by this paper
• The transcriptional program in the response of human fibroblasts to serum.

  1999cited by this paper
• The Integrin α9β1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1

  1999cited by this paper
• Induction of Cell Scattering by Expression of β1 Integrins in β1-Deficient Epithelial Cells Requires Activation of Members of the Rho Family of Gtpases and Downregulation of Cadherin and Catenin Function

  1999influential reference
• HMGI(Y) and HMGI-C dysregulation: a common occurrence in human tumors.

  1999cited by this paper
• Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes.

  1999cited by this paper
• Directional binding of HMG-I(Y) on four-way junction DNA and the molecular basis for competitive binding with HMG-1 and histone H1.

  1999influential reference
• The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis.

  1999influential reference
• HMG-I(Y) recognizes base-unpairing regions of matrix attachment sequences and its increased expression is directly linked to metastatic breast cancer phenotype.

  1999cited by this paper
• Induction of high mobility group-I(Y) protein by endotoxin and interleukin-1beta in vascular smooth muscle cells. Role in activation of inducible nitric oxide synthase.

  1999cited by this paper
• Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice

  1999cited by this paper
• Purification and assays for high mobility group HMG-I(Y) protein function.

  1999influential reference
• Retinoid-dependent Recruitment of a Histone H1 Displacement Activity by Retinoic Acid Receptor*

  1999cited by this paper
• Combining serial analysis of gene expression and array technologies to identify genes differentially expressed in breast cancer.

  1999cited by this paper
• Determination of high mobility group I(Y) expression level in colorectal neoplasias: a potential diagnostic marker.

  1999cited by this paper
• Cell-Extracellular Matrix Interactions Stimulate the AP-1 Transcription Factor in an Integrin-Linked Kinase- and Glycogen Synthase Kinase 3-Dependent Manner

  1999cited by this paper
• α9β1 Integrin is expressed on human neutrophils and contributes to neutrophil migration through human lung and synovial fibroblast barriers

  1999cited by this paper
• PTEN gene and integrin signaling in cancer.

  1999cited by this paper
• Integrin Function in Breast Carcinoma Progression

  1999cited by this paper
• Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo

  1999cited by this paper
• Integrin signaling.

  1999cited by this paper
• Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

  1998cited by this paper
• Enhancement of Serum-response Factor-dependent Transcription and DNA Binding by the Architectural Transcription Factor HMG-I(Y)*

  1998cited by this paper
• A matter of life and cell death.

  1998cited by this paper
• Expression of HMGI(Y) proteins in squamous intraepithelial and invasive lesions of the uterine cervix.

  1998cited by this paper
• Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not -resistant cells

  1998cited by this paper
• Identification of c-MYC as a target of the APC pathway.

  1998cited by this paper
• Targeted disruption of the beta1 integrin gene in a lymphoma cell line greatly reduces metastatic capacity.

  1998cited by this paper
• Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts

  1998cited by this paper
• Rho GTPases and the actin cytoskeleton.

  1998cited by this paper
• Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma.

  1998cited by this paper
• Signaling by integrin receptors

  1998cited by this paper
• Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways.

  1998cited by this paper
• Extracellular matrix signaling: integration of form and function in normal and malignant cells.

  1998cited by this paper
• Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.

  1998cited by this paper
• Focal adhesion kinase and its potential involvement in tumor invasion and metastasis

  1998cited by this paper
• Chromosomal translocations in benign tumors: the HMGI proteins.

  1998cited by this paper
• Integrin-linked Protein Kinase Regulates Fibronectin Matrix Assembly, E-cadherin Expression, and Tumorigenicity*

  1998cited by this paper
• Effects of Epidermal Growth Factor and Estrogen on the Regulation of the HMG-I/Y Gene in Human Mammary Epithelial Cell Lines

  1997influential reference
• Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactions.

  1997influential reference
• Functional Interaction between the DNA Binding Subunit Trimerization Domain of NF-Y and the High Mobility Group Protein HMG-I(Y)*

  1997cited by this paper
• Rho GTPases and signaling networks.

  1997cited by this paper
• Protein kinase mediators of integrin signal transduction

  1997cited by this paper
• Aggressive breast cancer leads to discrepant serum levels of the type I procollagen propeptides PINP and PICP.

  1997cited by this paper
• The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif

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• Overexpression of the Integrin-linked Kinase Promotes Anchorage-independent Cell Cycle Progression*

  1997cited by this paper
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  1997cited by this paper
• Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

  1997cited by this paper
• Competition between HMG-I(Y), HMG-1 and histone H1 on four-way junction DNA.

  1997influential reference
• MCF-7: the first hormone-responsive breast cancer cell line.

  1997cited by this paper
• Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

  1996influential reference
• Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains.

  1996influential reference
• Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

  1996cited by this paper
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  1996influential reference
• Epithelial differentiation and the control of metastasis in carcinomas.

  1996influential reference
• Epithelial-mesenchymal transitions in cancer progression.

  1996influential reference
• High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters.

  1996cited by this paper
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• Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

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• The adaptor protein Shc couples a class of integrins to the control of cell cycle progression.

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  1996cited by this paper
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  1996cited by this paper
• The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression.

  1995cited by this paper
• Use of tetracycline operator system to regulate oncogene expression in mammalian cells.

  1995cited by this paper
• Changes in Superhelicity Are Introduced into Closed Circular DNA by Binding of High Mobility Group Protein I/Y (*)

  1995cited by this paper
• Differential Regulation of a Multipromoter Gene.

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• An overview of epithelio-mesenchymal transformation.

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• MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.

  1995cited by this paper
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• Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y).

  1995cited by this paper
• Integrins and signal transduction pathways: the road taken.

  1995cited by this paper
• Mini-mouse: phenotypic characterization of a transgenic insertional mutant allelic to pygmy.

  1994cited by this paper
• Modulation of breast cancer progression and differentiation by the gp30/heregulin [correction of neregulin].

  1994cited by this paper
• Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-�B Family Proteins

  1994cited by this paper
• Regulation of vimentin gene transcription in human breast cancer cell lines.

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• Cooperativity between two NF-kappa B complexes, mediated by high-mobility-group protein I(Y), is essential for cytokine-induced expression of the E-selectin promoter.

  1994cited by this paper
• Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer.

  1994cited by this paper

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• Targeting HMGA1 contributes to immunotherapy in aggressive breast cancer while suppressing EMT.

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• A parasite DNA binding protein with potential to influence disease susceptibility acts as an analogue of mammalian HMGA transcription factors

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  2015cites this paper
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  2013cites this paper
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