A WD-repeat protein stabilizes ORC binding to chromatin.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Molecules and Cells

• Publication date

  2010-10-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.molcel.2010.09.021PMID 20932478PMCID PMC5201136
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Expression of lrwd1 in mouse testis and its centrosomal localization.

  2010cited by this paper
• Dynamics of Pre-replicative Complex Assembly*

  2010cited by this paper
• Conserved nucleosome positioning defines replication origins.

  2010cited by this paper
• Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.

  2010cited by this paper
• Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.

  2010cited by this paper
• Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization

  2010cited by this paper
• Replication initiation point mapping: approach and implications.

  2009cited by this paper
• TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres.

  2009cited by this paper
• Purification of proteins associated with specific genomic Loci.

  2009cited by this paper
• Establishing the program of origin firing during S phase in fission Yeast.

  2009cited by this paper
• Diversity of WD-repeat proteins.

  2008cited by this paper
• Centromere mitotic recombination in mammalian cells

  2008cited by this paper
• Diverse functions of WD40 repeat proteins in histone recognition.

  2008cited by this paper
• Involvement of human ORC and TRF2 in pre‐replication complex assembly at telomeres

  2008cited by this paper
• Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins

  2008cited by this paper
• Cdt1 and geminin: role during cell cycle progression and DNA damage in higher eukaryotes.

  2007influential reference
• New cell lines from mouse epiblast share defining features with human embryonic stem cells

  2007cited by this paper
• Multiple functions of the origin recognition complex.

  2007cited by this paper
• The origin recognition complex localizes to telomere repeats and prevents telomere-circle formation.

  2007influential reference
• Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.

  2007cited by this paper
• ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

  2007cited by this paper
• Role of the Orc6 Protein in Origin Recognition Complex-Dependent DNA Binding and Replication in Drosophila melanogaster

  2007cited by this paper
• Derivation of pluripotent epiblast stem cells from mammalian embryos

  2007cited by this paper
• The origin recognition complex functions in sister-chromatid cohesion in Saccharomyces cerevisiae.

  2007cited by this paper
• The many faces of the origin recognition complex.

  2007cited by this paper
• ATP-dependent Assembly of the Human Origin Recognition Complex*♦

  2007cited by this paper
• Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells

  2006cited by this paper
• Self‐renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phase

  2006cited by this paper
• Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance

  2005cited by this paper
• A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo.

  2005cited by this paper
• Recruitment of ORC or CDC6 to DNA is sufficient to create an artificial origin of replication in mammalian cells.

  2005cited by this paper
• Cell Cycle Dependent Regulation of the Origin Recognition Complex

  2005cited by this paper
• Eukaryotic origins of DNA replication: could you please be more specific?

  2005cited by this paper
• From silencing to gene expression: real-time analysis in single cells.

  2004cited by this paper
• Dynamics of pre-replication complex proteins during the cell division cycle.

  2004cited by this paper
• Subnuclear distribution of the largest subunit of the human origin recognition complex during the cell cycle

  2004influential reference
• The ORC1 Cycle in Human Cells

  2003cited by this paper
• HP1/ORC Complex and Heterochromatin Assembly

  2003cited by this paper
• Alternative lengthening of telomeres, telomerase, and cancer.

  2003cited by this paper
• Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin.

  2003cited by this paper
• Sequence-independent DNA binding and replication initiation by the human origin recognition complex.

  2003cited by this paper
• Cell cycle‐dependent regulation of the association between origin recognition proteins and somatic cell chromatin

  2002cited by this paper
• DNA replication in eukaryotic cells.

  2002cited by this paper
• Role for a Drosophila Myb-containing protein complex in site-specific DNA replication

  2002influential reference
• Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.

  2002cited by this paper
• Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms

  2001cited by this paper
• The Human Origin Recognition Complex Protein 1 Dissociates from Chromatin during S Phase in HeLa Cells*

  2001cited by this paper
• Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

  2001influential reference
• Stability, chromatin association and functional activity of mammalian pre‐replication complex proteins during the cell cycle

  2001cited by this paper
• Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin.

  2001cited by this paper
• Nucleosomes positioned by ORC facilitate the initiation of DNA replication.

  2001influential reference
• Orc mutants arrest in metaphase with abnormally condensed chromosomes.

  2001cited by this paper
• Subsets of Human Origin Recognition Complex (ORC) Subunits Are Expressed in Non-proliferating Cells and Associate with Non-ORC Proteins*

  2000cited by this paper
• Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.

  2000cited by this paper
• Inhibition of Eukaryotic DNA Replication by Geminin Binding to Cdt1

  2000influential reference
• Specification of Regions of DNA Replication Initiation during Embryogenesis in the 65-KilobaseDNApolα-dE2F Locus of Drosophila melanogaster

  1999cited by this paper
• ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP.

  1999influential reference
• The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks.

  1999cited by this paper
• Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins.

  1999cited by this paper
• Geminin, an inhibitor of DNA replication, is degraded during mitosis.

  1998influential reference
• Regulated chromosomal DNA replication in the absence of a nucleus.

  1998cited by this paper
• Identification of a Preinitiation Step in DNA Replication That Is Independent of Origin Recognition Complex and cdc6, but Dependent on cdk2

  1998cited by this paper
• Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.

  1997cited by this paper
• Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing

  1996cited by this paper
• The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin.

  1996cited by this paper
• Two steps in the assembly of complexes at yeast replication origins in vivo.

  1994cited by this paper
• Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos.

  1993cited by this paper
• Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

  1992cited by this paper
• ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

  1992influential reference
• Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs.

  1986cited by this paper

• Dynamic histone modification patterns coordinating DNA processes.

  2025cites this paper
• License to Replicate: Mechanisms of Licensing Eukaryotic Origins for DNA Replication

  2025cites this paper
• Nanopore-based sequencing of active DNA replication reveals key principles of metazoan replication fork progression, origin and termination sites

  2025cites this paper
• Regulation of epigenetics and chromosome structure by human ORC2

  2025cites this paper
• A Novel Multi-Tiered Hybrid Virtual Screening Pipeline for the Discovery of WDR5-MLL1 Interaction Disruptors in Precision Cancer Therapy

  2025cites this paper
• Germline-specific deletion of testis-highly expressed Lrwd1 reveals nonessential roles in male fertility.

  2025cites this paper
• Regulation of epigenetics and chromosome structure by human ORC2

  2025cites this paper
• MANCR lncRNA Modulates Cell-Cycle Progression and Metastasis by Cis-Regulation of Nuclear Rho-GEF

  2024cites this paper
• Specialized replication of heterochromatin domains ensures self-templated chromatin assembly and epigenetic inheritance

  2024cites this paper
• Chromatin’s Influence on Pre-Replication Complex Assembly and Function

  2024cites this paper
• Histone variant macroH2A1 regulates synchronous firing of replication origins in the inactive X chromosome

  2024cites this paper
• Origins of DNA replication in eukaryotes.

  2023cites this paper
• DNA replication and replication stress response in the context of nuclear architecture

  2023cites this paper
• Sexual antagonism and sex determination in three syngnathid species alongside male pregnancy gradient and varying sex roles.

  2023cites this paper
• Ubiquitination and deubiquitination: Implications on cancer therapy.

  2023cites this paper
• Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease

  2023cites this paper
• A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin

  2023cites this paper
• ORChestra coordinates the replication and repair music

  2023cites this paper
• Striatin family proteins: The neglected scaffolds.

  2023cites this paper
• Mobile origin-licensing factors confer resistance to conflicts with RNA polymerase

  2022cites this paper
• Lrwd1 impacts cell proliferation and the silencing of repetitive DNA elements

  2022influential citation
• The consequences of differential origin licensing dynamics in distinct chromatin environments

  2022cites this paper
• Nucleoporins facilitate ORC loading onto chromatin

  2022cites this paper
• f = m*a: A Framework for Investigating the Regulation of Replication Timing

  2022cites this paper
• The Initiation of Eukaryotic DNA Replication.

  2022cites this paper
• DNA replication timing: Biochemical mechanisms and biological significance

  2022cites this paper
• LRWD1 expression is regulated through DNA methylation in human testicular embryonal carcinoma cells

  2021cites this paper
• Nuclear Transglutaminase 2 interacts with topoisomerase II⍺ to promote DNA damage repair in lung cancer cells

  2021cites this paper
• PRSS50 is a testis protease responsible for proper sperm tail formation and function.

  2021cites this paper
• The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin

  2021cites this paper
• Orc6 at replication fork enables efficient mismatch repair

  2021cites this paper
• The Fkh1 Forkhead associated domain promotes ORC binding to a subset of DNA replication origins in budding yeast

  2021cites this paper
• Defining Proximity Proteome of Histone Modifications by Antibody-mediated Protein A-APEX2 Labeling

  2021cites this paper
• Replication initiation: Implications in genome integrity.

  2021cites this paper
• Methylation of Histone 4's Lysine 20: A critical analysis of the state of the field.

  2020cites this paper
• Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6

  2020cites this paper
• Structural insight into the assembly and conformational activation of human origin recognition complex

  2020cites this paper
• The E3 ligase RFWD3 stabilizes ORC in a p53-dependent manner

  2020cites this paper
• Positive and Negative Regulation of DNA Replication Initiation.

  2020cites this paper
• ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization

  2020cites this paper
• The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

  2019cites this paper
• Correction: Origins of DNA replication

  2019cites this paper
• Methyl-Readers and Inhibitors

  2019cites this paper
• Lysine-specific demethylase 2A enhances binding of various nuclear factors to CpG-rich genomic DNAs by action of its CXXC-PHD domain

  2019cites this paper
• A new class of disordered elements controls DNA replication through initiator self-assembly

  2019cites this paper
• Origins of DNA replication

  2019cites this paper
• DNA through

  2019cites this paper
• Biophysical and structural characterization of the thermostable WD40 domain of a prokaryotic protein, Thermomonospora curvata PkwA

  2018cites this paper
• Nuclear factor erythroid-2-related factor regulates LRWD1 expression and cellular adaptation to oxidative stress in human embryonal carcinoma cells.

  2018cites this paper
• Replication timing and nuclear structure.

  2018cites this paper
• WD40 Repeat Proteins: Signalling Scaffold with Diverse Functions

  2018cites this paper
• Nonreplicative functions of the origin recognition complex

  2018cites this paper
• Control of DNA Replication Initiation by Ubiquitin

  2018cites this paper
• Polo-like kinase 1 (PLK1)-dependent phosphorylation of methylenetetrahydrofolate reductase (MTHFR) regulates replication via histone methylation

  2017influential citation
• High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability.

  2017cites this paper
• TRF2 recruits ORC through TRFH domain dimerization.

  2017cites this paper
• Methyllysine binding domains: Structural insight and small molecule probe development.

  2017cites this paper
• DNA Replication Origins and Fork Progression at Mammalian Telomeres

  2017cites this paper
• SG2NA is a regulator of endoplasmic reticulum (ER) homeostasis as its depletion leads to ER stress

  2017cites this paper
• Chromatin-dependent pre-replication complex positioning and activation in mammals

  2017cites this paper
• Implication of Pre-replication Complex Proteins in Human Disease

  2017cites this paper
• Étude du rôle des méthyltransférases de la Lysine 20 de l’Histone H4 dans la dynamique de la chromatine au cours du cycle cellulaire

  2017cites this paper
• Mechanisms and regulation of DNA replication initiation in eukaryotes

  2017cites this paper
• Mechanisms for initiating cellular DNA replication

  2017cites this paper
• Histone H4K20 tri‐methylation at late‐firing origins ensures timely heterochromatin replication

  2017cites this paper
• A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events

  2017cites this paper
• Molecular Mechanism for Chromatin Regulation During MCM Loading in Mammalian Cells.

  2017cites this paper
• Defining the Role of the Histone Methyltransferase, PR-Set7, in Maintaining the Genome Integrity of Drosophila Melanogaster

  2016cites this paper
• Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization

  2016cites this paper
• An Interaction Proteomics Perspective on Chromatin Biology

  2016cites this paper
• A Role of hIPI3 in DNA Replication Licensing in Human Cells

  2016cites this paper
• Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner

  2016cites this paper
• Orc1 Binding to Mitotic Chromosomes Precedes Spatial Patterning during G1 Phase and Assembly of the Origin Recognition Complex in Human Cells*

  2015cites this paper
• Les fonctions et rôles régulateurs de l'acétylation dans le maintien de l'intégrité du génome

  2015cites this paper
• A Computational and Informatics Framework for the Analysis of Affinity Purification Mass Spectrometry Data and Reconstruction of Protein Interaction Networks.

  2015cites this paper
• How the cell cycle impacts chromatin architecture and influences cell fate

  2015cites this paper
• Characteristics of Metazoan DNA Replication Origins

  2015cites this paper
• Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

  2015cites this paper
• proteome one methyl moiety at a time

  2015cites this paper
• Investigating the mechanism of geminin inactivation

  2015influential citation
• Peaks cloaked in the mist: The landscape of mammalian replication origins

  2015influential citation
• Association of ORCA/LRWD1 with repressive histone methyl transferases mediates heterochromatin organization

  2015cites this paper
• Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time*

  2015cites this paper
• The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin

  2015cites this paper
• Mind the Methyl: Methyllysine Binding Proteins in Epigenetic Regulation

  2014cites this paper
• Single‐nucleotide polymorphisms in the LRWD1 gene may be a genetic risk factor for Japanese patients with Sertoli cell‐only syndrome

  2014cites this paper
• Dynamic Phosphorylation of HP1α Regulates Mitotic Progression in Human Cells

  2014cites this paper
• Isolation of chromatin from dysfunctional telomeres reveals an important role for Ring1b in NHEJ-mediated chromosome fusions.

  2014cites this paper
• DNA replication and transcription programs respond to the same chromatin cues

  2014cites this paper
• Cellular senescence and protein degradation

  2014cites this paper
• Correlation between leucine rich domain and the stability of LRWD1 protein in human NT2/D1 cells.

  2014cites this paper
• Role of DNA replication in establishment and propagation of epigenetic states of chromatin.

  2014cites this paper
• Helicase loading: how to build a MCM2-7 double-hexamer.

  2014cites this paper
• Fundamentals of Chromatin

  2014cites this paper
• Systems Analysis of Chromatin-Related Protein Complexes in Cancer

  2014cites this paper
• Fonctions antitumorales de la voie ERK/MAPK et développement rationnel de nouvelles stratégies thérapeutiques

  2014cites this paper
• The epigenetic regulation of cell cycle and chromatin dynamic by sirtuins

  2014influential citation
• Exploring Chromatin Readers Using High-Accuracy Quantitative Mass Spectrometry-Based Proteomics

  2014cites this paper
• Reading Histone Modifications

  2014cites this paper
• Protéine impliquée dans la réplication de l'adn, et modulation de son activité

  2014cites this paper