Succinate Modulation as a Biochemical Correlate of Metabolic and Neurobehavioral Changes Associated With Intermittent Fasting in Obesity

Andrea Tognozzi,F. Carli,Sherif Abdelkarim,Sara Cornuti,Francesca Damiani,Maria Grazia Giuliano,Alice Miniati,Martina Nasisi,Lia De Benedictis,Kousha Changizi Ashtiani,G. Scabia,M. Maffei,Pierre Baldi,A. Gastaldelli,Paola Tognini

Published 2025 in Acta Physiologica

ABSTRACT

Obesity significantly impacts the central nervous system (CNS), increasing the risks of neuropsychiatric disorders and dementia. Intermittent fasting (IF) shows promise for improving peripheral and CNS health, but its mechanisms are unclear.

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