Novel Therapeutic Approach to Preserving or Reversing Pancreatic Islet Beta Cells in Patients With Type 1 Diabetes: A Bayesian Network Meta‐Analysis of Comparative Efficacy

Cheng Zheng,Sibiao Lu,Di Qiang,Jiale Xu,Yingying Xu

Published 2026 in Diabetes/Metabolism Research Reviews

ABSTRACT

Type 1 diabetes accounts for approximately 10% of all diabetes cases, meaning that a substantial number of patients require lifelong insulin therapy. Although many individuals adapt to the demands of daily injections, they remain vulnerable to hypoglycaemia and long‐term complications, particularly when glycaemic control is suboptimal. These persistent challenges have driven the search for effective treatments that may improve quality of life and potentially induce clinical remission. To address this need, we conducted a Bayesian network meta‐analysis to evaluate the capacity of non‐insulin therapies to preserve pancreatic β‐cell function in type 1 diabetes.

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