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Harnessing the connection of the Wnt/beta-catenin pathway and other signaling pathways in glioblastoma multiforme.

A. Nakhaei,Sadaf Afshari,Elmira Mohatshami,Mohammad Jalili-Nik,Mahsa Jalali,Kasim Sakran Abass,Amir R. Afshari,Prashant Kesharwani,A. Sahebkar

Published 2026 in Critical reviews in oncology/hematology

ABSTRACT

Finding the proper and most effective treatment is significant because glioblastoma (GB), the most common and aggressive type of brain tumor, has been very hard for the healthcare system to deal with. Usually, standard treatments for this type of tumor take a long time to work. Even when they do, they can cause a lot of harmful side effects. One possible way to do this is to look at essential signaling pathways, especially the Wnt/beta-catenin pathway. This pathway controls some cellular connections in both healthy and unhealthy states of development. Recent findings have clarified the unique anticancer characteristics of the Wnt/beta-catenin pathway and its interrelations with other cellular pathways. These advantages have increased hopes for finding the right treatments for all types of cancer, even GB. A suggested answer focuses on critical signaling pathways, especially the Wnt/beta-catenin pathway. This pathway regulates various cellular interactions in both normal development and disease states. Recent discoveries have elucidated the distinctive anticancer properties of the Wnt/beta-catenin pathway and its interactions with other cellular pathways. These benefits have made people hopeful that they will be able to find the best treatment for all types of cancer, including GB. ‎.

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