Autoimmune skin disease pathogenesis: a chronological immune cascade and multi-hit model

No abstract is available for this paper.

• Publication year

  2026

• Venue

  Immunity & Inflammation

• Publication date

  2026-01-20

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1007/s44466-025-00017-x
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo.

  2025cited by this paper
• A Temporal and Spatial Atlas of Adaptive Immune Responses in the Lymph Node Following Viral Infection

  2025cited by this paper
• PLZF-expressing CD4+ T cells promote tissue-resident memory T cells in breaking immune tolerance in allergic asthma via IL-15/IL-15Rα signaling

  2025cited by this paper
• Systemic rewiring of dendritic cells by melanoma-secreted midkine impairs immune surveillance and response to immune checkpoint blockade

  2025cited by this paper
• CD8+T cell exhaustion: the potential for treating autoimmune diseases.

  2025cited by this paper
• Trained Immunity Affecting Dendritic Cell Differentiation and Function in Rheumatoid Arthritis

  2025cited by this paper
• Immune Memory: A New Frontier in Treating Recurrent Inflammatory Skin Diseases

  2025cited by this paper
• Recent clinical and mechanistic insights into vitiligo offer new treatment options for cell-specific autoimmunity

  2025cited by this paper
• Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8+ T cells to cytokine deficiency.

  2025cited by this paper
• Effectiveness and safety of ruxolitinib cream in Chinese patients with nonsegmental vitiligo.

  2025cited by this paper
• Melanocyte-dependent macrophage redistribution enhances skin immunity upon acute stress

  2025cited by this paper
• Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo.

  2025cited by this paper
• CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence

  2025cited by this paper
• Transcriptomic profiling of vitiligo patients shows polar immune dysregulation in involved and uninvolved skin.

  2025cited by this paper
• Tissue-resident memory CD4+ T cells infiltrate the CNS in progressive multiple sclerosis and contribute to chronic autoimmunity in mice.

  2025cited by this paper
• Scalable TCR synthesis and screening enables antigen reactivity mapping in vitiligo

  2025cited by this paper
• Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.

  2025cited by this paper
• Therapeutic Advancements in Psoriasis and Psoriatic Arthritis

  2025cited by this paper
• The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes.

  2024cited by this paper
• Restoring tolerance with antigen delivery

  2024cited by this paper
• Oxidized Melanoma Antigens Promote Activation and Proliferation of Cytotoxic T‐Cell Subpopulations

  2024cited by this paper
• Inflammatory Memory in Psoriasis: From Remission to Recurrence.

  2024cited by this paper
• Inflammatory Memory in Chronic Skin Disease

  2024cited by this paper
• Disorganisation of basement membrane zone architecture impairs melanocyte residence in vitiligo

  2024cited by this paper
• The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects.

  2024cited by this paper
• Conversion of dendritic cells into tolerogenic or inflammatory cells depends on the activation threshold and kinetics of the mTOR signaling pathway

  2024cited by this paper
• The extracellular matrix integrates mitochondrial homeostasis

  2024cited by this paper
• The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program.

  2024cited by this paper
• Immune Checkpoint Inhibitor-Induced Vitiligo-Like Depigmentation.

  2024cited by this paper
• CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8+ T cells in diabetic autoimmunity.

  2024cited by this paper
• Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines.

  2024cited by this paper
• Pemphigus relapse: Mechanisms, risk factors, and agents associated with disease recurrence

  2024cited by this paper
• Beyond The Skin: B Cells in Pemphigus Vulgaris, Tolerance and Treatment.

  2024cited by this paper
• Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy

  2024cited by this paper
• DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways

  2024influential reference
• Long-Term Risk of Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19.

  2024cited by this paper
• Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences

  2024cited by this paper
• Single-cell sequencing reveals distinct immune cell features in cutaneous lesions of pemphigus vulgaris and bullous pemphigoid.

  2024influential reference
• Bridging Molecular Mechanism and Clinical Practice in Vitiligo Treatment: An Updated Review

  2024cited by this paper
• Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells

  2024cited by this paper
• Exploring new perspectives in immunology.

  2024cited by this paper
• The state of the art in the treatment of severe aplastic anemia: immunotherapy and hematopoietic cell transplantation in children and adults

  2024cited by this paper
• An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy

  2024cited by this paper
• Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes.

  2024cited by this paper
• Spatial programming of fibroblasts promotes resolution of tissue inflammation through immune cell exclusion

  2024cited by this paper
• Single-cell spatiotemporal analysis reveals alveolar dendritic cell–T cell immunity hubs defending against pulmonary infection

  2024cited by this paper
• Innate immune sensing of cell death in disease and therapeutics

  2024cited by this paper
• Microneedle‐Mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia

  2024cited by this paper
• Membranal Expression of Calreticulin Induced by Unfolded Protein Response in Melanocytes: A Mechanism Underlying Oxidative Stress-induced Autoimmunity in Vitiligo.

  2024cited by this paper
• Impaired autophagy in myeloid cells aggravates psoriasis-like skin inflammation through the IL-1β/CXCL2/neutrophil axis

  2024cited by this paper
• Teplizumab induces persistent changes in the antigen-specific repertoire in individuals at risk for type 1 diabetes

  2024cited by this paper
• Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics.

  2024cited by this paper
• CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.

  2024cited by this paper
• Lymphangiogenesis: novel strategies to promote cutaneous wound healing

  2024cited by this paper
• Immunopeptidome mining reveals a novel ERS-induced target in T1D

  2024cited by this paper
• Virus as the cause of type 1 diabetes.

  2024cited by this paper
• Single-cell transcriptomic analysis identifies infiltrating plasmacytoid dendritic cells in psoriasis epidermis.

  2024cited by this paper
• Immune interplay from circulation to local lesion in pemphigus pathogenesis.

  2024cited by this paper
• The correlation analysis between alterations of serum vitamin D, IL‐33 levels, and clinical improvement after narrow‐band UVB treatment in vitiligo patients: A case–control study

  2024cited by this paper
• High-dimensional profiling of regulatory T cells in psoriasis reveals an impaired skin-trafficking property

  2024cited by this paper
• Immune disease dialogue of chemokine-based cell communications as revealed by single-cell RNA sequencing meta-analysis

  2024cited by this paper
• Single-cell transcriptome analysis reveals interaction between CCL19+ inflammatory keratinocytes and CCR7+ dendritic cells and B cells in pemphigus.

  2024cited by this paper
• Hair regrowth in alopecia areata and re‐pigmentation in vitiligo in response to treatment: Commonalities and differences

  2024cited by this paper
• Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential

  2024cited by this paper
• The Immunology of Psoriasis—Current Concepts in Pathogenesis

  2024cited by this paper
• Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis.

  2024cited by this paper
• Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during inflammation

  2024cited by this paper
• Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics

  2023cited by this paper
• Impact of COVID-19 Vaccine and COVID-19 Infection on Vitiligo Activity and Progression

  2023cited by this paper
• Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a.

  2023cited by this paper
• B Cell-Directed Therapy in Autoimmunity.

  2023cited by this paper
• A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas.

  2023cited by this paper
• Single-cell transcriptomics suggest distinct upstream drivers of IL-17A/F in hidradenitis versus psoriasis.

  2023cited by this paper
• Differential expression of extracellular matrix proteins in the lesional skin of vitiligo patients

  2023cited by this paper
• Structural basis of NINJ1-mediated plasma membrane rupture in cell death

  2023cited by this paper
• Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters

  2023influential reference
• ISG15-USP18 dysregulation by oxidative stress promotes IFN-γ secretion from CD8+ T cells in vitiligo.

  2023cited by this paper
• The tissue-resident regulatory T cell pool is shaped by transient multi-tissue migration and a conserved residency program

  2023cited by this paper
• Systems immunology of regulatory T cells: can one circuit explain it all?

  2023cited by this paper
• CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients

  2023cited by this paper
• Cardinal features of immune memory in innate lymphocytes

  2023cited by this paper
• An IGFBP7hi endothelial cell subset drives T cell extravasation in psoriasis via endothelial glycocalyx degradation

  2023cited by this paper
• Toward a general model of CD4+ T cell subset specification and memory cell formation.

  2023cited by this paper
• Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15

  2023cited by this paper
• Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity

  2023cited by this paper
• Defining the landscape of human epidermal mononuclear phagocytes.

  2023cited by this paper
• Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

  2023cited by this paper
• Mitophagy and immune infiltration in vitiligo: evidence from bioinformatics analysis

  2023influential reference
• Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy.

  2023cited by this paper
• Glycyl-tRNA synthetase induces psoriasis-like skin by facilitating skin inflammation and vascular endothelial cell angiogenesis.

  2023cited by this paper
• The extracellular matrix and the immune system: A mutually dependent relationship

  2023cited by this paper
• CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence

  2023cited by this paper
• Using mass spectrometry to identify neoantigens in autoimmune diseases: The type 1 diabetes example.

  2023cited by this paper
• Efficacy and safety of oral upadacitinib monotherapy in patients with recalcitrant vitiligo.

  2023cited by this paper
• Resident memory T cell precursors in tumor draining lymph nodes require type-1 IFN for optimal differentiation

  2023cited by this paper
• A virtual memory CD8^+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity

  2023cited by this paper
• Functional interrogation of lymphocyte subsets in alopecia areata using single-cell RNA sequencing.

  2023cited by this paper
• Childhood vitiligo developing after COVID-19 infection

  2023cited by this paper
• PD-1 maintains CD8 T cell tolerance towards cutaneous neoantigens

  2023cited by this paper
• Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells

  2023cited by this paper

• No citing papers are available for this paper.