The Loxtox protein family in Loxosceles intermedia (Mello-Leitão) venom.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Toxicon

• Publication date

  2007-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.TOXICON.2007.07.001PMID 17825864
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Two novel dermonecrotic toxins LiRecDT4 and LiRecDT5 from brown spider (Loxosceles intermedia) venom: from cloning to functional characterization.

  2007cited by this paper
• Structural insights into the catalytic mechanism of sphingomyelinases D and evolutionary relationship to glycerophosphodiester phosphodiesterases.

  2006cited by this paper
• North and South American Loxosceles spiders: development of a polyvalent antivenom with recombinant sphingomyelinases D as antigens.

  2006cited by this paper
• Molecular cloning and functional characterization of two isoforms of dermonecrotic toxin from Loxosceles intermedia (brown spider) venom gland.

  2006cited by this paper
• Functional characterization and epitope analysis of a recombinant dermonecrotic protein from Loxosceles intermedia spider.

  2006cited by this paper
• Brown spider dermonecrotic toxin directly induces nephrotoxicity.

  2006cited by this paper
• Molecular diversification in spider venoms: A web of combinatorial peptide libraries

  2006cited by this paper
• Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA).

  2005cited by this paper
• Sphingomyelinase D from venoms of Loxosceles spiders: evolutionary insights from cDNA sequences and gene structure.

  2005cited by this paper
• Were arachnids the first to use combinatorial peptide libraries?

  2005cited by this paper
• Proteome analysis of brown spider venom: Identification of loxnecrogin isoforms in Loxosceles gaucho venom

  2005cited by this paper
• Loxosceles sphingomyelinase induces complement-dependent dermonecrosis, neutrophil infiltration, and endogenous gelatinase expression.

  2005cited by this paper
• Enzymatic characterization, antigenic cross-reactivity and neutralization of dermonecrotic activity of five Loxosceles spider venoms of medical importance in the Americas.

  2005cited by this paper
• Conformational changes of Loxosceles venom sphingomyelinases monitored by circular dichroism.

  2005cited by this paper
• Characterization of the venom from the Brazilian Brown Spider Loxosceles similis Moenkhaus, 1898 (Araneae, Sicariidae).

  2005cited by this paper
• Analysis of the toxic potential of venom from Loxosceles adelaida, a Brazilian brown spider from karstic areas.

  2005cited by this paper
• Genetic and enzymatic characterization of sphingomyelinase D isoforms from the North American fiddleback spiders Loxosceles boneti and Loxosceles reclusa.

  2004cited by this paper
• Identification and molecular cloning of insecticidal toxins from the venom of the brown spider Loxosceles intermedia.

  2004cited by this paper
• Molecular cloning, expression, function and immunoreactivities of members of a gene family of sphingomyelinases from Loxosceles venom glands.

  2004cited by this paper
• Loxoscelism: old obstacles, new directions.

  2004cited by this paper
• Molecular cloning and characterization of Phoneutria nigriventer toxins active on calcium channels.

  2003cited by this paper
• Production of monoclonal antibodies capable of neutralizing dermonecrotic activity of Loxosceles intermedia spider venom and their use in a specific immunometric assay.

  2003cited by this paper
• Protection against dermonecrotic and lethal activities of Loxosceles intermedia spider venom by immunization with a fused recombinant protein.

  2003cited by this paper
• Identification of proteases in the extract of venom glands from brown spiders.

  2002cited by this paper
• Molecular cloning, expression and immunological properties of LiD1, a protein from the dermonecrotic family of Loxosceles intermedia spider venom.

  2002cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Screening of expression libraries using ELISA: identification of immunogenic proteins from Tityus bahiensis and Tityus serrulatus venom.

  2001cited by this paper
• MEGA2: molecular evolutionary genetics analysis software

  2001cited by this paper
• Sphingomyelinases in the venom of the spider Loxosceles intermedia are responsible for both dermonecrosis and complement-dependent hemolysis.

  1998cited by this paper
• Detection and characterization of metalloproteinases with gelatinolytic, fibronectinolytic and fibrinogenolytic activities in brown spider (Loxosceles intermedia) venom.

  1998cited by this paper
• Cloning of cDNAS encoding neurotoxic peptides from the spider Phoneutria nigriventer.

  1998cited by this paper
• ELISA for the detection of venom antigens in experimental and clinical envenoming by Loxosceles intermedia spiders.

  1998cited by this paper
• Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

  1997cited by this paper
• Identification and neutralization of biological activities in the venoms of Loxosceles spiders.

  1996cited by this paper
• Two-dimensional electrophoresis with immobilized pH gradients: current state.

  1993cited by this paper

• Predictive analysis of B-cell antigenic epitopes in phospholipase D toxins from Loxosceles spiders

  2025cites this paper
• Induction of ectosome formation by binding of phospholipases D from Loxosceles venoms to endothelial cell surface: Mechanism of interaction.

  2024cites this paper
• Subtranscriptome analysis of phospholipases D in Loxosceles venom glands: Confirmation of predominance, intra-species diversity, and description of novel isoforms.

  2024cites this paper
• A roadmap to the enzymes from spider venom: biochemical ecology, molecular diversity, and value for the bioeconomy

  2024cites this paper
• The C-terminal mutation beyond the catalytic site of brown spider phospholipase D significantly impacts its biological activities.

  2023cites this paper
• Analysis of NGS data from Peruvian Loxosceles laeta spider venom gland reveals toxin diversity.

  2022cites this paper
• Sphingomyelinases in a journey to combat arthropod‐borne pathogen transmission

  2021cites this paper
• Novel Mutant Phospholipase D from Hemiscorpius lepturus Acts as A Highly Immunogen in BALB/c Mice Against the Lethality of Scorpion Venom

  2020cites this paper
• Forty Years of the Description of Brown Spider Venom Phospholipases-D

  2020cites this paper
• Antigenic and Substrate Preference Differences between Scorpion and Spider Dermonecrotic Toxins, a Comparative Investigation

  2020cites this paper
• Biotechnological potential of Phospholipase D for Loxosceles antivenom development

  2020cites this paper
• Molecular cloning and functional characterization of recombinant Loxtox from Loxosceles similis venom.

  2020cites this paper
• Toxicological Characterization and Phospholipase D Activity of the Venom of the Spider Sicarius thomisoides

  2020cites this paper
• From taxonomy to molecular characterization of brown spider venom: an overview focused on Loxosceles similis.

  2019cites this paper
• Arthropod venoms: Biochemistry, ecology and evolution

  2019cites this paper
• Brown Spider (Loxosceles) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics

  2019cites this paper
• Spider's venom phospholipases D: A structural review.

  2018cites this paper
• Loxosceles gaucho Spider Venom: An Untapped Source of Antimicrobial Agents

  2018cites this paper
• Characteristics and Lethality of a Novel Recombinant Dermonecrotic Venom Phospholipase D from Hemiscorpius lepturus

  2017cites this paper
• Citotoxicidade e inflamação : a atividade da toxina dermonecrótica do veneno de aranha-marrom sobre membranas de células endoteliais in vitro

  2017cites this paper
• Highlights in the knowledge of brown spider toxins

  2017cites this paper
• Identificação de peptídeos ICK e de isoformas de uma proteína homóloga a alérgenos no veneno de aranhas do gênero loxosceles

  2016cites this paper
• Description of Loxtox protein family and identification of a new group of Phospholipases D from Loxosceles similis venom gland.

  2016cites this paper
• Active site mapping of Loxosceles phospholipases D: Biochemical and biological features.

  2016cites this paper
• Venom Genomics and Proteomics

  2016cites this paper
• Pattern of inflammatory response to Loxosceles intermedia venom in distinct mouse strains: a key element to understand skin lesions and dermonecrosis by poisoning.

  2015cites this paper
• Anti-loxoscelic horse serum produced against a recombinant dermonecrotic protein of Brazilian Loxosceles intermedia spider neutralize lethal effects of Loxosceles laeta venom from Peru.

  2015cites this paper
• Helminthes and insects: maladies or therapies

  2015cites this paper
• Estudo dos peptídeos pertencentes à família ICK presentes no veneno das aranhas do gênero Loxosceles

  2015cites this paper
• Brown spider (Loxosceles genus) venom toxins: Evaluation of biological conservation by immune cross-reactivity.

  2015cites this paper
• Not as docile as it looks? Loxosceles venom variation and loxoscelism in the Mediterranean Basin and the Canary Islands.

  2015cites this paper
• Loxosceles and Loxoscelism: Biology, Venom, Envenomation and Treatment

  2015cites this paper
• Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins.

  2014cites this paper
• Generation and molecular characterization of a monoclonal antibody reactive with conserved epitope in sphingomyelinases D from Loxosceles spider venoms.

  2014cites this paper
• Innovative immunization protocols using chimeric recombinant protein for the production of polyspecific loxoscelic antivenom in horses.

  2014cites this paper
• Spit and venom from scytodes spiders: a diverse and distinct cocktail.

  2014cites this paper
• Brown Spider Venom: The Identification and Biotechnological Potential of Venom Toxins

  2014cites this paper
• A novel ICK peptide from the Loxosceles intermedia (brown spider) venom gland: cloning, heterologous expression and immunological cross-reactivity approaches.

  2013cites this paper
• Lysophosphatidic acid mediates the release of cytokines and chemokines by human fibroblasts treated with loxosceles spider venom.

  2013cites this paper
• Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom.

  2013cites this paper
• Spider-venom peptides: structure, pharmacology, and potential for control of insect pests.

  2013cites this paper
• Generation and characterization of a recombinant chimeric protein (rCpLi) consisting of B-cell epitopes of a dermonecrotic protein from Loxosceles intermedia spider venom.

  2013cites this paper
• Brown spider phospholipase‐D containing a conservative mutation (D233E) in the catalytic site: Identification and functional characterization

  2013influential citation
• Biochemical and immunological characteristics of Peruvian Loxosceles laeta spider venom: neutralization of its toxic effects by anti-loxoscelic antivenoms.

  2013cites this paper
• Cloning, expression and characterization of a phospholipase D from Loxosceles gaucho venom gland.

  2013cites this paper
• Molecular cloning, heterologous expression and functional characterization of a novel translationally-controlled tumor protein (TCTP) family member from Loxosceles intermedia (brown spider) venom.

  2012cites this paper
• Sponge implant in Swiss mice as a model for studying loxoscelism.

  2012cites this paper
• Cutaneous loxoscelism caused by Loxosceles similis venom and neutralization capacity of its specific antivenom.

  2012cites this paper
• The relationship between calcium and the metabolism of plasma membrane phospholipids in hemolysis induced by brown spider venom phospholipase‐D toxin

  2011influential citation
• Brown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes

  2011cites this paper
• Crystallization and preliminary X-ray diffraction analysis of a class II phospholipase D from Loxosceles intermedia venom.

  2011cites this paper
• Phospholipase-D activity and inflammatory response induced by brown spider dermonecrotic toxin: endothelial cell membrane phospholipids as targets for toxicity.

  2011cites this paper
• CLONAGEM E EXPRESSÃO HETERÓLOGA DE UM PEPTÍDEO DA FAMÍLIA DAS NOTINAS PRESENTE NO VENENO DA ARANHA MARROM (Loxosceles intermedia)

  2011cites this paper
• Venom Composition and Strategies in Spiders: Is Everything Possible?

  2011cites this paper
• Protection against the toxic effects of Loxosceles intermedia spider venom elicited by mimotope peptides.

  2011cites this paper
• Structure of a novel class II phospholipase D: catalytic cleft is modified by a disulphide bridge.

  2011cites this paper
• Inflammatory mediators generated at the site of inoculation of Loxosceles gaucho spider venom.

  2010cites this paper
• Astacin-like metalloproteases are a gene family of toxins present in the venom of different species of the brown spider (genus Loxosceles).

  2010cites this paper
• Comparative analyses of venoms from American and African Sicarius spiders that differ in sphingomyelinase D activity.

  2010cites this paper
• Cardiotoxic effects of Loxosceles intermedia spider venom and the recombinant venom toxin rLiD1.

  2010cites this paper
• A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis.

  2010cites this paper
• A novel sphingomyelinase‐like enzyme in Ixodes scapularis tick saliva drives host CD4+ T cells to express IL‐4

  2009cites this paper
• Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase‐D (dermonecrotic toxin) from brown spider venom

  2009influential citation
• Analysis of therapeutic benefits of antivenin at different time intervals after experimental envenomation in rabbits by venom of the brown spider (Loxosceles intermedia).

  2009cites this paper
• An in vivo protective response against toxic effects of the dermonecrotic protein from Loxosceles intermedia spider venom elicited by synthetic epitopes.

  2009cites this paper
• Nephrotoxicity of insect and spider venoms in Latin America.

  2008cites this paper
• Molecular evolution, functional variation, and proposed nomenclature of the gene family that includes sphingomyelinase D in sicariid spider venoms.

  2008cites this paper
• Estudos da atividade nefrotóxica da toxina dermonecrótica (fosfolipase-D) do veneno da aranha marrom Loxosceles intermedia /

  2008cites this paper
• Nephrotoxicity caused by brown spider venom phospholipase-D (dermonecrotic toxin) depends on catalytic activity.

  2008cites this paper